Flavor & Fragrance
Product Name:
(* Alt. CAS #) CAS: 24680-50-0; trans-p-Methoxy cinammic aldehyde, 2-Propenal, 3-(4-methoxyphenyl)-, 3-(4-Methoxyphenyl)-2-propenal, 3-(4-Methoxyphenyl)acrylaldehyde, 4-Methoxycinnamaldehyde, p-Methoxycinnamaldehyde, para-METHOXY CINNAMIC ALDEHYDE (PMCA)
CAS Number:
Molecular Weight:
Molecular Formula:
Olfactive Family:
Odor description:
A pleasant cinnamon note that is not overpowering.
Chemical Structure

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Reference Reading

1.Nematicidal Activity of Cassia and Cinnamon Oil Compounds and Related Compounds toward Bursaphelenchus xylophilus (Nematoda: Parasitaphelenchidae).
Kong JO1, Lee SM, Moon YS, Lee SG, Ahn YJ. J Nematol. 2007 Mar;39(1):31-6.
The nematicidal activity of two cassia, Cinnamomum cassia, oils (Especial and true), four cinnamon, Cinnamomum zey-lanicum, oils (technical, #500, bark and green leaf), and their compounds (e.g., trans-cinnamaldehyde and trans-cinnamic acid) toward adult Bursaphelenchus xylophilus was examined by a direct contact bioassay. Results were compared with those of 34 related compounds. As judged by 24-hour LC(50) values, two cassia oils (0.084-0.085 mg/ml) and four cinnamon oils (0.064-0.113 mg/ml) were toxic toward adult B. xylophilus. Of 45 test compounds, trans-cinnamaldehyde (0.061 mg/ml) was the most active nematicide, followed by ethyl cinnamate, alpha-methyl-trans-cinnamaldehyde, methyl cinnamate and allyl cinnamate (0.114-0.195 mg/ml). Potent nematicidal activity was also observed with 4-methoxycinnamonitrile, trans-4-methoxycinnamaldehyde, trans-2-methoxy-cinnamaldehyde, ethyl alpha-cyanocinnamate, cinnamonitrile and cinnamyl bromide (0.
2.Differentiating Parts of Cinnamomum Cassia using LC-qTOF-MS in Conjunction with Principal Component Analysis.
Chen PY1, Yu JW1, Lu FL1, Lin MC1, Cheng HF1. Biomed Chromatogr. 2016 Feb 12. doi: 10.1002/bmc.3703. [Epub ahead of print]
Cinnamon bark (Rou Gui in Chinese), cinnamon twig (Gui Zhi), and shaved cinnamon bark (Gui Sin) have been widely used as spices and in traditional Chinese medicine since ancient times. On-going issues related to quality and authenticity necessitate the development of analytical methods capable of providing an objective evaluation of samples. In this study, chemical fingerprints of cinnamon bark, cinnamon twigs, and shaved cinnamon bark were established using liquid chromatography quadruple time-of-flight mass spectrometry (LC-qTOF-MS) in conjunction with principal component analysis (PCA). From 125 samples of cinnamon, we identified the following eight compounds and their the detection ratios: coumarin, cinnamaldehyde, cinnamyl alcohol, cinnamic acid, 2-hydroxycinnamaldehyde, 2-hydroxycinnamic acid, 2-methoxycinnamaldehyde, and 4-methoxycinnamaldehyde. Of these, 4-methoxycinnamaldehyde presented the largest variations in detection ratio, making up 64.
3.4-Methoxycinnamaldehyde inhibited human respiratory syncytial virus in a human larynx carcinoma cell line.
Wang KC1, Chang JS, Chiang LC, Lin CC. Phytomedicine. 2009 Sep;16(9):882-6. doi: 10.1016/j.phymed.2009.02.016. Epub 2009 Mar 19.
4-Methoxycinnamaldehyde, an active constituent of Agastache rugosa, was examined for its cytoprotective activity against RSV by XTT method in human larynx carcinoma cell line. 4-Methoxycinnamaldehyde could effectively inhibit cytopathic effect of RSV (p<0.0001) with an estimated IC(50) of 0.055microg/ml and a selectivity index (SI) of 898.2. 4-Methoxycinnamaldehyde (0.03microg/ml) could inhibit viral entrance by interfering viral attachment (IC(50) of 0.06microg/ml; p<0.0001) and internalization (IC(50) of 0.01microg/ml; p<0.0001). 4-Methoxycinnamaldehyde significantly increased the basal production of IFN (p=0.0015), but not the virus-induced IFN production. Therefore, its cytoprotective activity against RSV was not mediated by interferon. In conclusion, 4-methoxycinnamaldehyde might be helpful to manage the disease induced by RSV infection.
4.Orientation disruption of Diabrotica virgifera virgifera in maize by a liquid MCA formulation released from paper squares in the Banat region of Serbia and Montenegro.
Hummel HE1, Baca FI, Erski P. Commun Agric Appl Biol Sci. 2003;68(4 Pt A):99-104.
Serbia-Montenegro, formerly the Republic of Yugoslavia, is the first European Country where Diabrotica virgifera virgifera Le Conte (Col.: Chrysomelidae) (D.v.v.) was reported in 1992 as an invasive alien pest species, Baca (1993), Camprag and Baca, (1995): From a focal point near Belgrade airport, the maize pest quickly spread in all directions reaching the economic threshold in a number of surrounding countries around 1995. The field experiments described took place in the Banat region east of Belgrade in July of 2002. The plant kairomone mimic 4-methoxycinnamaldehyde (MCA) dissolved in acetone was slowly volatilized from paper squares. It permeated a maize field of known D.v.v. history of 0.5 ha size 3 km north of the village of Crepaja. With release rates of 266 g/ha, max. orientation disruption levels of 55% were achieved. The total amount of MCA was distributed in two manual applications. Readings of orientation levels were continued for eleven days during the latter part of July and into early August of 2002.