1.Characterization of carbon-containing aerosolized drugs using laser-induced breakdown spectroscopy.
Mukherjee D1, Cheng MD. Appl Spectrosc. 2008 May;62(5):554-62. doi: 10.1366/000370208784344451.
Aerosolized drug delivery methods have increasingly become popular for pharmaceutical applications. This is mainly due to their ease of application and the more recent advancements incorporating nano-sized generation of particles that find deeper penetration routes and more efficient administration of the drug to specific target organs. Their effectiveness heavily relies on the uniformity of the chemical composition of these aerosolized drugs. Thus, it calls for a real-time on-line analytical tool that can accurately characterize the chemical constituents of the drug powder particles generated to ensure a stringent quality control. We present laser-induced breakdown spectroscopy (LIBS) for the first time as an efficient analytical tool to carry out on-line quantitative chemical characterization of aerosolized drugs. We used three different carbon based aerosolized drugs, namely L-ascorbic acid 2-phosphate sesquimagnesium salt hydrate (C(6)H(9)Mg(1.