(-)-Nebivolol - CAS 118457-16-2
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
(-)-Nebivolol
Catalog Number:
118457-16-2
Synonyms:
(αS,α’S,2R,2’S)-α,α’-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]; [2S-[2R*[R*[R*(S*)]]]]-α,α’-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro- 2H-1-benzopyran-2-methanol; Levonebivolol; R 67145; l-Nebivolol
CAS Number:
118457-16-2
Description:
This active molecular is a β-adrenergic receptor antagonist. Levonebivolol is an enantiomer of Nebivolol which is a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension and left ventricular failure in Europe. It is highly cardioselective under certain circumstances. In Apr 2015, US FDA approved an ANDA for nebivolol submitted by Amerigen. In Jan 2016, Forest Laboratories and the University of Chicago withdrew a phase II/III trial for Hypertension in patients with chronic obstructive pulmonary disease in USA .
Molecular Weight:
405.44
Molecular Formula:
C22H25F2NO4
Quantity:
Milligrams-Grams
Quality Standard:
In-house standard
COA:
Inquire
MSDS:
Inquire
Canonical SMILES:
C1CC2=C(C=CC(=C2)F)OC1C(CNCC(C3CCC4=C(O3)C=CC(=C4)F)O)O
InChI:
InChI=1S/C22H25F2NO4/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2/t17-,18-,21-,22-/m0/s1
InChIKey:
KOHIRBRYDXPAMZ-GPHNJDIKSA-N
Targets:
Adrenergic Receptor
Current Developer:
Duncan; Forest Laboratories; Janssen; Menarini
Chemical Structure
CAS 118457-16-2 (-)-Nebivolol

Related Adrenergic Receptor Products


CAS 6452-71-7 Oxprenolol

Oxprenolol
(CAS: 6452-71-7)

Oxprenolol is a lipophilic, non-selective beta-adrenergic blocker. It has some intrinsic sympathomimetic activity and is used for the treatment of angina pector...

CAS 51322-75-9 Tizanidine

Tizanidine
(CAS: 51322-75-9)

Tizanidine, a short-acting drug, is an agonist at a2-adrenergic receptor reducing spasticity by increasing presynaptic inhibition of motor neurons.

CAS 33402-03-8 Metaraminol tartrate

Metaraminol tartrate
(CAS: 33402-03-8)

Metaraminol is a stereoisomer of meta-hydroxynorephedrine, acts as An adrenergic agonist that increases both systolic and diastolic blood pressure.

CAS 5874-97-5 Metaproterenol hemisulfate salt

Metaproterenol hemisulfate salt
(CAS: 5874-97-5)

Metaproterenol hemisulfate salt is the hemisulfate salt form of Metaproterenol, which is a moderately selective beta-adrenergic agonist. It is used in the treat...

Solabegron
(CAS: 451470-34-1)

Solabegron is a selective β3-adrenergic receptor agonist used for the treatment of irritable bowel syndrome.

CAS 106463-17-6 Tamsulosin HCl

Tamsulosin HCl
(CAS: 106463-17-6)

The hydrochloride salt form of Tamsulosin which could block on the sympathetic α1 receptor, especially selectively bind to the α1A receptor so that has been fou...

CAS 56392-17-7 Metoprolol Tartrate

Metoprolol Tartrate
(CAS: 56392-17-7)

Metoprolol Tartrate is a cardioselective β-adrenergic receptor blocker with IC50 of 42 ng/mL.

MK-467
(CAS: 130466-38-5)

MK-467 is a peripheral Alpha2 -adrenoceptor antagonist originated by Merck & Co. It can dose-dependently attenuate the bradycardia associated with dexmedetomidi...

CAS 3506-09-0 Propranolol Hydrochloride

Propranolol Hydrochloride
(CAS: 3506-09-0)

Propranolol Hydrochloride is a β-adrenergic antagonist used to treat high blood pressure, a number of types of irregular heart rate, thyrotoxicosis, capillary h...

CAS 5985-28-4 Synephrine Hydrochloride

Synephrine Hydrochloride
(CAS: 5985-28-4)

SynephrineHCl (Oxedrine, p-Synephrine) is a sympathomimetic α-adrenergic receptor (AR) agonist.

CAS 108929-47-1 CGP-12388

CGP-12388
(CAS: 108929-47-1)

CGP-12388 is a beta-adrenoceptor antagonist-derived radioligands. It is used for cardiac PET imaging due to its high hydrophilicity and affinity to beta-adrenoc...

CAS 81403-80-7 Alfuzosin

Alfuzosin
(CAS: 81403-80-7)

Alfuzosin is a pharmaceutical drug of the alpha-1 blocker class. It works by relaxing the muscles in the prostate and bladder neck. It is used to treat benign p...

CAS 70359-46-5 Brimonidine Tartrate

Brimonidine Tartrate
(CAS: 70359-46-5)

Brimonidine Tartrate is a highly selective α-adrenergic receptor agonist with EC50 of 0.45 nM for the α2A adrenoreceptor, and used to treat open-angle glaucoma ...

CAS 56-47-3 Deoxycorticosterone acetate

Deoxycorticosterone acetate
(CAS: 56-47-3)

Deoxycorticosterone acetate is a steroid hormone used for intramuscular injection for replacement therapy of the adrenocortical steroid.

CAS 57149-07-2 Naftopidil

Naftopidil
(CAS: 57149-07-2)

Naftopidil is a selective α1-adrenergic receptor antagonist or alpha blocker with a Ki of 58.3 nM.

CAS 51-43-4 L-Adrenaline

L-Adrenaline
(CAS: 51-43-4)

L-Adrenaline belongs to a group of the compounds known as catecholamines.

Fenoterol hydrochloride
(CAS: 1944-10-1)

Fenoterol hydrochloride is a β2 adrenoreceptor agonist used as a bronchodilator for the treatment and prophylaxis of reversible bronchospasm, administered by in...

CAS 54765-26-3 Lerimazoline

Lerimazoline
(CAS: 54765-26-3)

Lerimazoline is an α-adrenergic receptor agonist. It inhibits secretion of nasal mucus. It causes hypertension. It is common used in the form of hydrochloride.

CAS 829-74-3 Levonordefrin

Levonordefrin
(CAS: 829-74-3)

Levonordefrin is a adrenergic receptor agonist and can be used as a topical nasal decongestant and vasoconstrictor in dentistry in the United States. Levonordef...

CAS 71576-40-4 Aptazapine

Aptazapine
(CAS: 71576-40-4)

Aptazapine is a tetracyclic antidepressant. It was assayed in clinical trials for the treatment of depression in the 1980s but was never marketed. Aptazapine is...