1.Antihyperlipidemic and Antioxidant Activities of Edible Tunisian Ficus carica L. Fruits in High Fat Diet-Induced Hyperlipidemic Rats.
Belguith-Hadriche O1,2, Ammar S3,4, Contreras MD4, Turki M5, Segura-Carretero A4, El Feki A6, Makni-Ayedi F5, Bouaziz M7. Plant Foods Hum Nutr. 2016 Apr 16. [Epub ahead of print]
The phenolic constituents of the aqueous-ethanolic extract of Tunisian Ficus carica (F. carica) fruit (FE) and its antihyperlipidemic and antioxidant activities in high-fat diet-induced hyperlipidemic rats (HFD) were evaluated. The obtained results demonstrated that the FE improved the lipid profile by decreasing the total cholesterol, triglyceride, low-density lipoprotein cholesterol and increasing high-density lipoprotein cholesterol levels. It also reduced the content of thiobarbituric acid-reactive substances and increased the antioxidant enzymes in liver, heart and kidney in HFD-fed rats. These antihyperlipidemic effects and in vivo antioxidative effects correlated with the in vitro phenolic content scavenging ability. Thus, the major phenolic compounds were identified using reversed-phase ultra-high-performance liquid chromatography (RP-UHPLC) coupled with two detection systems: diode-array detection (DAD) and quadrupole time-of-flight (QTOF) mass spectrometry (MS).
2.Does disorder get "into the head" and "under the skin"? Layered contexts and bi-directional associations.
Upenieks L1, Schafer MH2, Iveniuk J3. Health Place. 2016 Apr 14;39:131-141. doi: 10.1016/j.healthplace.2016.03.009. [Epub ahead of print]
This paper utilizes a layered context approach to examine how neighborhood and household conditions are associated with the objective and subjective well-being of older adults. Using two waves of data from the National Social Life, Health, and Aging Project (n=2261), we assess subjective mental health through self-reported measures of perceived stress and distress and objective physical health through C-reactive protein (CRP). Environmental disorder was measured by independent, trained interviewers. Cross-sectional results indicate that household disorder is positively associated with perceived stress and distress, overwhelming the association between neighborhood disorder and mental health outcomes. Yet longitudinal findings point to a reverse process, whereby highly stressed women experience deterioration in their home environment across the two waves. Few significant findings surfaced for CRP. Taken together, our findings illustrate the complex interplay between health and proximal environments and underscore how feedback cycles operate between "health" and "place" across multiple outcomes.
3.Discriminability of personality profiles in isolated and Co-morbid marijuana and nicotine users.
Ketcherside A1, Jeon-Slaughter H2, Baine JL1, Filbey FM3. Psychiatry Res. 2016 Apr 30;238:356-62. doi: 10.1016/j.psychres.2016.02.024. Epub 2016 Feb 16.
Specific personality traits have been linked with substance use disorders (SUDs), genetic mechanisms, and brain systems. Thus, determining the specificity of personality traits to types of SUD can advance the field towards defining SUD endophenotypes as well as understanding the brain systems involved for the development of novel treatments. Disentangling these factors is particularly important in highly co morbid SUDs, such as marijuana and nicotine use, so treatment can occur effectively for both. This study evaluated personality traits that distinguish isolated and co-morbid use of marijuana and nicotine. To that end, we collected the NEO Five Factor Inventory in participants who used marijuana-only (n=59), nicotine-only (n=27), both marijuana and nicotine (n=28), and in non-using controls (n=28). We used factor analyses to identify personality profiles, which are linear combinations of the five NEO Factors. We then conducted Receiver Operating Characteristics (ROC) curve analysis to test accuracy of the personality factors in discriminating isolated and co-morbid marijuana and nicotine users from each other.
4.Use of PET tracers for parathyroid localization: a systematic review and meta-analysis.
Kluijfhout WP1,2, Pasternak JD3, Drake FT4, Beninato T4, Gosnell JE4, Shen WT4, Duh QY4, Allen IE5, Vriens MR6, de Keizer B7, Pampaloni MH8, Suh I4. Langenbecks Arch Surg. 2016 Apr 16. [Epub ahead of print]
PURPOSE: The great spatial and temporal resolution of positron emission tomography might provide the answer for patients with primary hyperparathyroidism (pHPT) and non-localized parathyroid glands. We performed a systematic review of the evidence regarding all investigated tracers.