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N-Cyclohexyl-2-benzothiazolesulfenamide - CAS 95-33-0

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Category
Main Product
Product Name
N-Cyclohexyl-2-benzothiazolesulfenamide
Catalog Number
95-33-0
Synonyms
2-(cyclohexylaminothio)benzothiazole;accicurehbs;benzothiazyl-2-cyclohexylsulfenamide;conaca;conach;conacs;curax;cyclohexyl_2_benzothiazolesulfenamide
CAS Number
95-33-0
Molecular Weight
264.40
Molecular Formula
C13H16N2S2
COA
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MSDS
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Structure
CAS 95-33-0 N-Cyclohexyl-2-benzothiazolesulfenamide
Specification
Purity
98%
Boiling Point
410.4ºC at 760 mmHg
Melting Point
93-100ºC
Density
1.31~1.34g/cm3
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Reference Reading
1.Evaluation of the teratogenic potential of the rubber accelerator N-cyclohexyl-2-benzothiazylsulfenamide in rats.
Ema M1, Murai T, Itami T, Kawasaki H, Kanoh S. J Appl Toxicol. 1989 Jun;9(3):187-90.
The teratogenicity of N-cyclohexyl-2-benzothiazylsulfenamide (CBS) was studied in Wistar rats. Pregnant rats were given CBS at a dosage of 0.001, 0.01, 0.1 or 0.5% in the diet from Day 0 to Day 20 of pregnancy. Daily intakes of CBS were 0.7 mg kg-1 for the 0.001% group, 7.1 mg kg-1 for the 0.01% group, 69.6 mg kg-1 for the 0.1% group and 288.8 mg kg-1 for the 0.5% group. Maternal body weight gain during pregnancy in the 0.1 and 0.5% groups was significantly lowered. Food consumption during pregnancy in the CBS-treated groups, except for the 0.5% group, did not differ from that in the control group. Neither death nor clinical signs of toxicity were noted in the pregnant females of any group. Lowered weight in fetuses and the placentae were observed in the 0.5% group. There were no significant compound-related effects on the incidences of pre- and post-implantation losses and the number and ratio of live fetuses. Morphological examinations of the fetuses revealed no evidence of teratogenesis.
2.[Absorption, distribution, metabolism and excretion of N-cyclohexyl-2-benzothiazyl sulfenamide (CBS), a vulcanizing accelerator, in rats].
Adachi T1, Tanaka A, Yamaha T. Radioisotopes. 1989 May;38(5):255-8.
Absorption, distribution, metabolism and excretion were studied in rats following a single oral administration of N-cyclohexyl-2-benzothiazyl sulfenamide (CBS) at a dose of 250 mg/kg. About 65% and 24% of the dose were excreted into urine and feces, respectively, for 3 days after administration of labeled CBS (cyclohexyl-14C). Biliary excretion amounted to about 5% of the dose for 3 days. While about 92% of the dose was recovered in urine and feces at a ratio of 1:1 within 3 days when 14C-2CBS was given. No specific organ-affinity was observed in distribution study. Cyclohexylamine and 2-mercaptobenzothiazole were identified as urinary metabolites.
3.Stability of the mercaptobenzothiazole compounds.
Hansson C1, Agrup G. Contact Dermatitis. 1993 Jan;28(1):29-34.
An analytical quantitative high-pressure liquid chromatography (HPLC) method was developed for simultaneous determination of all mercaptobenzothiazole derivatives in the mercapto mix patch testing standard. The stability of the mercaptobenzothiazoles constituting the mercapto mix was studied both in petrolatum and in buffer solution at pH 6.5, with and without glutathione. In petrolatum vehicle, dibenzothiazyl disulfide was the dominant compound found in stored mercapto mix. In buffer solution at pH 6.5, 2-mercaptobenzothiazole and the sulfenamide derivatives morpholinyl mercaptobenzothiazole and N-cyclohexyl-2-benzothiazyl sulfenamide were converted into dibenzothiazyl disulfide. In the presence of glutathione, both the sulfenamide derivatives and the dibenzothiazyl disulfide were rapidly converted into 2-mercaptobenzothiazole. The findings explain the "cross-sensitivities" reported for the mercaptobenzothiazole group as a result of chemical reactions resulting in one main hapten.
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