N-4-Boc-N-1-Cbz-2-piperazine carboxylic acid - CAS 126937-41-5
Catalog number: 126937-41-5
Category: Main Product
Molecular Formula:
C18H24N2O6
Molecular Weight:
364.39
COA:
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Purity:
95%
Synonyms:
126937-41-5; N-4-Boc-N-1-Cbz-2-piperazinecarboxylicacid; 4-Boc-1-Cbz-2-piperazinecarboxylicacid; 1-((Benzyloxy)carbonyl)-4-(tert-butoxycarbonyl)piperazine-2-carboxylicacid; 1-(benzyloxycarbonyl)-4-(tert-butoxycarbonyl)piperazine-2-carboxylicacid; 4-Boc-1-Cbz-2-Piperazinecarboxylicacid
MSDS:
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Quantity:
Data not available, please inquire.
Boiling Point:
518.9ºC at 760 mmHg
Melting Point:
150-152ºC
Density:
1.272
InChIKey:
MKXMXZZARNRMMQ-UHFFFAOYSA-N
InChI:
InChI=1S/C18H24N2O6/c1-18(2,3)26-16(23)19-9-10-20(14(11-19)15(21)22)17(24)25-12-13-7-5-4-6-8-13/h4-8,14H,9-12H2,1-3H3,(H,21,22)
Canonical SMILES:
CC(C)(C)OC(=O)N1CCN(C(C1)C(=O)O)C(=O)OCC2=CC=CC=C2
1.Identification of transformation products of antiviral drugs formed during biological wastewater treatment and their occurrence in the urban water cycle.
Funke J1, Prasse C2, Ternes TA3. Water Res. 2016 Mar 24;98:75-83. doi: 10.1016/j.watres.2016.03.045. [Epub ahead of print]
The fate of five antiviral drugs (abacavir, emtricitabine, ganciclovir, lamivudine and zidovudine) was investigated in biological wastewater treatment. Investigations of degradation kinetics were accompanied by the elucidation of formed transformation products (TPs) using activated sludge lab experiments and subsequent LC-HRMS analysis. Degradation rate constants ranged between 0.46 L d-1 gSS-1 (zidovudine) and 55.8 L d-1 gSS-1 (abacavir). Despite these differences of the degradation kinetics, the same main biotransformation reaction was observed for all five compounds: oxidation of the terminal hydroxyl-moiety to the corresponding carboxylic acid (formation of carboxy-TPs). In addition, the oxidation of thioether moieties to sulfoxides was observed for emtricitabine and lamivudine. Antiviral drugs were detected in influents of municipal wastewater treatment plants (WWTPs) with concentrations up to 980 ng L-1 (emtricitabine), while in WWTP effluents mainly the TPs were found with concentration levels up to 1320 ng L-1 (carboxy-abacavir).
2.A fundamental investigation into aspects of the physiology and biochemistry of the stratum corneum in subjects with sensitive skin.
Raj N1, Voegeli R2, Rawlings AV1, Doppler S2, Imfeld D2, Munday MR1, Lane ME1. Int J Cosmet Sci. 2016 Apr 15. doi: 10.1111/ics.12334. [Epub ahead of print]
BACKGROUND: Sensitive skin is a poorly understood skin condition. Defects in stratum corneum (SC) barrier function and/or extrasensory neuronal networks in the epidermis are believed to be involved in the problem.
3.Thermodynamic Strategies for C-O Bond Formation and Cleavage via Tandem Catalysis.
Lohr TL1, Li Z1, Marks TJ1. Acc Chem Res. 2016 Apr 14. [Epub ahead of print]
To reduce global reliance on fossil fuels, new renewable sources of energy that can be used with the current infrastructure are required. Biomass represents a major source of renewable carbon based fuel; however, the high oxygen content (∼40%) limits its use as a conventional fuel. To utilize biomass as an energy source, not only with current infrastructure, but for maximum energy return, the oxygen content must be reduced. One method to achieve this is to develop selective catalytic methods to cleave C-O bonds commonly found in biomass (aliphatic and aromatic ethers and esters) for the eventual removal of oxygen in the form of volatile H2O or carboxylic acids. Once selective methods of C-O cleavage are understood and perfected, application to processing real biomass feedstocks such as lignin can be undertaken. This Laboratory previously reported that recyclable "green" lanthanide triflates are excellent catalysts for C-O bond-forming hydroalkoxylation reactions.
4.Interactions of Zn(II) Ions with Humic Acids Isolated from Various Type of Soils. Effect of pH, Zn Concentrations and Humic Acids Chemical Properties.
Boguta P1, Sokołowska Z1. PLoS One. 2016 Apr 14;11(4):e0153626. doi: 10.1371/journal.pone.0153626. eCollection 2016.
The main aim of this study was the analysis of the interaction between humic acids (HAs) from different soils and Zn(II) ions at wide concentration ranges and at two different pHs, 5 and 7, by using fluorescence and FTIR spectroscopy, as well as potentiometric measurements. The presence of a few areas of HAs structures responsible for Zn(II) complexing was revealed. Complexation at α-sites (low humified structures of low-molecular weight and aromatic polycondensation) and β-sites (weakly humified structures) was stronger at pH 7 than 5. This trend was not observed for γ-sites (structures with linearly-condensed aromatic rings, unsaturated bonds and large molecular weight). The amount of metal complexed at pH5 and 7 by α and γ-structures increased with a decrease in humification and aromaticity of HAs, contrary to β-areas where complexation increased with increasing content of carboxylic groups. The stability of complexes was higher at pH 7 and was the highest for γ-structures.
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CAS 126937-41-5 N-4-Boc-N-1-Cbz-2-piperazine carboxylic acid

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