N-(2-Fluorophenyl)-guanidine - CAS 41213-65-4
Catalog number: 41213-65-4
Category: Main Product
Molecular Formula:
C7H8FN3
Molecular Weight:
153.16
COA:
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Purity:
95%
Synonyms:
N-(2-FLUORO-PHENYL)-GUANIDINE
MSDS:
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Quantity:
Data not available, please inquire.
InChIKey:
GOKVJPDWTFRCEV-UHFFFAOYSA-N
InChI:
InChI=1S/C7H8FN3/c8-5-3-1-2-4-6(5)11-7(9)10/h1-4H,(H4,9,10,11)
Canonical SMILES:
C1=CC=C(C(=C1)N=C(N)N)F
1.A study comparing the antisecretory effect of TAK-438, a novel potassium-competitive acid blocker, with lansoprazole in animals.
Hori Y1, Matsukawa J, Takeuchi T, Nishida H, Kajino M, Inatomi N. J Pharmacol Exp Ther. 2011 Jun;337(3):797-804. doi: 10.1124/jpet.111.179556. Epub 2011 Mar 16.
Proton pump inhibitors (PPIs) are widely used for the treatment of acid-related diseases. However, several medical needs such as suppression of night-time acid secretion and rapid symptom relief remain unmet. In this study, we investigated the effects of 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate (TAK-438), a novel potassium-competitive acid blocker, on acid secretion in rats and dogs under various conditions, in comparison with the PPI lansoprazole [2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl] methyl]sulfinyl]-1H-benzimidazole], to characterize the antisecretory action of TAK-438. TAK-438 showed a more potent and longer-lasting inhibitory effect than lansoprazole on the histamine-stimulated gastric acid secretion in rats and dogs. A pharmacokinetic study in rats showed that TAK-438 accumulated and was retained in the gastric tissue for more than 24 h, unlike that in the plasma. TAK-438 showed significant antisecretory activity with or without cimetidine pretreatment, in contrast to lansoprazole, which did not show antisecretory activity after cimetidine pretreatment in rats.
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CAS 41213-65-4 N-(2-Fluorophenyl)-guanidine

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