1.Luminal cholinergic signalling in airway lining fluid: a novel mechanism for activating chloride secretion via Ca²⁺-dependent Cl⁻ and K⁺ channels.
Hollenhorst MI1, Lips KS, Wolff M, Wess J, Gerbig S, Takats Z, Kummer W, Fronius M. Br J Pharmacol. 2012 Jun;166(4):1388-402. doi: 10.1111/j.1476-5381.2012.01883.x.
BACKGROUND AND PURPOSE: Recent studies detected the expression of proteins involved in cholinergic metabolism in airway epithelial cells, although the function of this non-neuronal cholinergic system is not known in detail. Thus, this study focused on the effect of luminal ACh as a regulator of transepithelial ion transport in epithelial cells.