Mitomycin C - CAS 50-07-7
Not Intended for Therapeutic Use. For research use only.
Category:
ADCs
Product Name:
Mitomycin C
Catalog Number:
50-07-7
CAS Number:
50-07-7
Description:
Mitomycin C is a DNA crosslinking agent that inhibits DNA synthesis and induces apoptosis in a variety of cells.
Molecular Weight:
334.33
Molecular Formula:
C15H18N4O5
COA:
Inquire
MSDS:
Inquire
Tag:
ADCs Cytotoxin
Chemical Structure
CAS 50-07-7 Mitomycin C

Related ADCs Cytotoxin Products


Bucharidine
(CAS: 25865-94-5)

Quinoline Alkaloid Extracted from Haplophyllum bucharicum

Convolidine
(CAS: 63911-32-0)

Steroidal Alkaloid from Convolvulus krauseanus

CAS 101-31-5 (-)-Hyoscyamine

(-)-Hyoscyamine
(CAS: 101-31-5)

Hyoscyamine is a tropane alkaloid. It is a secondary metabolite found in certain plants of the family Solanaceae, non-selective antagonist at Muscarinic recepto...

Agitoxin-2
(CAS: 168147-41-9)

Agitoxin-2 is a potent and selective blocker of the Shaker type voltage-gated Kv1.3 and Kv1.1 channels. Agitoxin-2 inhibits Kv1.3 with an IC50 value of around 2...

CAS 129203-60-7 Iberiotoxin

Iberiotoxin
(CAS: 129203-60-7)

Selective blocker of the big conductance Ca2+-activated K+ channel.

CAS 79580-28-2 Brevetoxin B

Brevetoxin B
(CAS: 79580-28-2)

Brevetoxin B is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. It binds to site 5 on the alpha subunit of voltage-gated sodium c...

CAS 90-47-1 Xanthone

Xanthone
(CAS: 90-47-1)

Xanthonoid Purified from Hypericum perforatum

CAS 28808-62-0 Fraxinellone

Fraxinellone
(CAS: 28808-62-0)

Fraxinellone is an insecticidal agent, inhibiting growth of larvae, used in the treatment and protection of crops and produce. Also, a naturally occurring compo...

Maytansinoid DM4
(CAS: 799840-96-3)

DM4 is a cytotoxic agent. It is used as the cytotoxic component in antibody-drug conjugates.

CAS 117048-59-6 Combretastatin A4

Combretastatin A4
(CAS: 117048-59-6)

Combretastatin A4, under the IUPAC name 2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenol, inhibits tubulin polymerization (IC50= 2.2 μM). It has demons...

FSP-2

Anticoagulant: irreversible inhibitor of serine proteinase a-thrombine. Fluorocontaining phosphonate, synthetised.

CAS 33069-62-4 Paclitaxel

Paclitaxel
(CAS: 33069-62-4)

Paclitaxel is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.

CAS 86408-17-5 Askendoside D

Askendoside D
(CAS: 86408-17-5)

Askendoside D presents a high selectivity for the cardiac Na+/K+-ATPase, with practically no activity on brain or kidney Na+/K+-ATPases, as compared with other ...

CAS 45651-41-0 Q Me

Q Me
(CAS: 45651-41-0)

Synthetic, nicotinic AChR. Rigid bicyclic analog of TMA and TEA.

CAS 35846-53-8 Maytansine

Maytansine
(CAS: 35846-53-8)

Maitansine, a cytotoxic agent, inhibits the assembly of microtubules by binding to tubulin at the rhizoxin binding site.

CAS 20449-79-0 Melittin

Melittin
(CAS: 20449-79-0)

Melittin inhibits protein kinase C, Ca2+/calmodulin-dependent protein kinase II, myosin light chain kinase and Na+/K+-ATPase (synaptosomal membrane) and is a ce...

CAS 5008-52-6 Napelline

Napelline
(CAS: 5008-52-6)

Napelline is a diterpenoid alkaloid from plants of the Aconitum,genus, a potent antiarrhythmic with weak hypotensive and N-cholinoblocking effects.

Subhirsine
(CAS: 85412-77-7)

Tropane Alkaloid Extracted from Convolvulus subhirsutus

CAS 485-49-4 (+)-Bicuculline

(+)-Bicuculline
(CAS: 485-49-4)

Ionotropic GABAA receptors are ligand-gated ion channels that facilitate the passing of chloride ions across the cell membrane and promote an inhibitory influen...

CAS 65988-34-3 Alpha-Latrotoxin

Alpha-Latrotoxin
(CAS: 65988-34-3)

A latrotoxin is a high-molecular mass neurotoxin found in the venom of spiders of the genus Latrodectus (widow spiders). Latrotoxins are the main active compone...

Reference Reading


Mitomycin C use during glaucoma surgery has played an important role in improving our rates of surgical success. However, surgical complications related to the use of mitomycin C have been a cause of great concern. In this report we describe an unusual complication in two cases related to retained sponge fragments used to apply mitomycin C on the ocular surface. Both patients in this report presented with bleb-related inflammation 4 months after surgery. In the first patient the presentation was suggestive of an infection and, even though cultures were negative, a concurrent infection could not be excluded. The timing of the bleb-related inflammation seen in both patients was, however, not typical of filtering surgery after anitimetabolite use. Most bleb-related inflammation is seen either in the late postoperative period secondary to infections in thin or leaking blebs or, less commonly, in the early postoperative period.
2.Scleral punch method with topical mitomycin c for safe revision of failed deep sclerectomy in nanophthalmic uveal effusion syndrome
Nelson A. Sabrosa & Henry B. Smith & Robert E. MacLaren. Graefes Arch Clin Exp Ophthalmol (2009) 247:999–1001
We also applied mitomycin c (MMC) to inhibit further scarring, and we propose that this might be used more widely in UES, as has been recommended by others. Re-exploration in this case confirmed that the previous full-thickness sclera windows had become occluded by fibrosis and scarring. Trabeculectomy is now almost uniformly performed with anti-mitotics to prevent bleb failure, and a major difference here is that MMC is applied more posteriorly, over the sclerectomy at the globe equator. This may limit the anterior segment complications associated with MMC, such as cystic bleb formation. The aetiology of nanophthalmic UES remains unclear, although sclerectomy does appear to be effective when performed successfully. Here we describe a scleral punch method combined with mitomycin c (MMC) for successful revision of scarred sclerectomy. We believe that knowledge of this technique may be useful to other surgeons operating on similar eyes.