|Description||Microcystin-LR is a selective inhibitor of protein phosphatase 2A (PP2A) (IC50= 0.04 nM) and will completely inhibit this enzyme without affecting PP1 when used at a concentration of 0.5 nM.2 The PP1 IC50 is about 1.7 nM. Microcystins are at least 10 times more potent as serine/threonine PP inhibitors than okadaic acid, another microalgal toxin also used for this purpose.|
Anticoagulant: irreversible inhibitor of serine proteinase a-thrombine. Fluorocontaining phosphonate, synthetised.
Laticauda semifasciata III
Polypetide, an antagonist of the nicotinic acetylcholine receptor at the neuromuscular junction with a weaker affinity to the receptor than Erabutoxins a and b.
Synthetic organophosphorous compound, a non-competitive GABA antagonist; potent convulsant: causes epileptoform seizures.
Xanthonoid Purified from Hypericum perforatum
Diamine oxidase activator. Na+ channels blocker.
An anesthetic acting on the nerve endings, with a good selectivity on sensory nerves; lowers arterial pressure; vasodilator. Tropane alkaloid , from plants of t...
Synthetic, from Scorpio maurus palmatus scorpion venom. An activator of Ca2+ release channel/ryanodine receptors. 33-mer basic peptide cross-linked by three dis...
A Norditerpenoid alkaloid. Nicotinic receptor antagonist at the neuromuscular junction and vegetative ganglia; hypotensive. Diterpene alkaloid , from plants of ...
Potent antagonist for α7-containing neuronal nicotinic receptors (Ki = 1.4 nM). Interacts with α4β2 and α6β2 receptors at concentrations > 40 nM. Attenuates MET...
An activator of voltage-sensitive Na+ channels, a suite of cyclic polyether compounds produced naturally by a species of dinoflagellate known as Karenia brevis....
A substance which inhibits cholinesterases reversibly. Alkaloid , from plants of the Zygophyllaceae family
a CNS stimulant. Alkaloid, , purified from plants of Coffea genus, Rubiaceae.
A highly active peripheral M2-cholinoblocker alkaloid. Cervane alkaloid derivative of Imperialine from the plant Petilium eduardi.
C19-norditerpenoid alkaloid , from plants of the Ranunculaceae family, a potent antiarrhythmic, antifibrillatory; Na+ channel blocker in cardiomyocytes.
α-Cobratoxin is a substance of the venom of certain Naja cobras. It is a nicotinic acetylcholine receptor (nAChR) antagonist which causes paralysis by preventin...
Synthetic, nicotinic AChR. Rigid bicyclic analog of TMA and TEA.
omega conotoxin MVIIA
ω conotoxin MVIIA (omega conotoxin MVIIA) has been isolated from the venom of the cone Conus magus. Omega-conotoxins act at presynaptic membranes, they bind and...
A muscarinic receptors antagonist.
A methyl easter of Okadaic acid. Okadaic acid is a marine sponge toxin which potently inhibits certain serine/threonine protein phosphatases.