1. Ion-selective Electrode for the Determination of Metoclopramide
S. S. Badawy, A. F. Shoukry and Y. M. lssa. ANALYST, DECEMBER 1986, VOL. 111
Although many methods, other than potentiometry, have been reported for the determination of MCP, most of them are complicated and need sophisticated instrumentation such as HPLC or GLC. The low cost and ease of operation of potentiometric instrumentation make the potentiometric determination of MCP+ a highly desirable alternative. For this reason, and as a result of the medical importance of MCP, it was of interest to investigate the performance characteristics of an MCP-selective membrane electrode based on the MCP ion pair with tetraphenylboron (TPB) incorporated in a poly(viny1 chloride) (PVC) matrix and to use this electrode for the analysis of Primperan syrup and Plasil tablets.
2. One-step fabrication of core–shell structured alginate–PLGA/PLLA microparticles as a novel drug delivery system for water soluble drugs
Ming Pin Alan Lim, Wei Li Lee, Eﬀendi Widjajab and Say Chye Joachim Loo*. Biomater. Sci., 2013, 1, 486–493
As such, the release profiles can be tuned according to diﬀusion kinetics and degradation rates of the polymer used. In addition, the objectives include studying how certain key synthesis parameters would result in the formation of a core–shell structure, and the mechanisms leading to the formation of core–shell microparticles. Metoclopramide hydrochloride (MCA), a model hydrophilic drug, was used, and the release of this drug was compared between this core–shell particulate system against a pure system of calcium alginate (CaAlg) beads. As a therapeutic agent, MCA is used as an antiemetic and a gastroprokinetic agent for the treatment of nausea and gastric stasis. It is also used as a radiosensitizer/chemosensitizer for lung carcinoma treatment.
3. Stability-indicating High-performance Liquid Chromatographic Assay for the Determination of Metoclopramide Hydrochloride in Pharmaceutical Dosage Forms
Mohammad S. Suleiman, Naji M. Najib and Yousry M. El-Sayed. ANALYST, MARCH 1989, VOL. 114
Metoclopramide hydrochloride is a benzamide derivative structurally related to procainamide with potent antiemetic and antispasmodic effects. Various analytical techniques have been developed for the determination of this drug in biological fluids, including spectrophotometry and thin-layer chromato-graphy - colorimetry, gas chromatography - mass spectrometry, high-performance liquid chromatography (HPLC) and electron-capture gas - liquid chromatography. However, very few methods have been developed for the determination of 1 in pharmaceutical dosage forms. The method of Sidhu et al. is a general method and does not employ an internal standard. The current BP method13 for the determination of 1 in tablet formulations is based on spectrophotometry. However, the method is time consuming as it involves a solvent extraction step and is not selective. For a quality control laboratory, the essential features of any analytical method are its speed, simplicity and specificity. This paper describes an HPLC method for the determination of 1 in tablets, the most commonly used dosage form.
4. Studying the compatibility of a metoclopramide-HCl–paracetamol mixture via IHCMC and establishing a validated RP-HPLC method for its determination in tablets
Amira M. Hegazy,* Raimar Loebenberg, Nagiba Y. Hassan. Anal. Methods, 2013, 5, 3714–3720
Metoclopramide hydrochloride (MCP-HCl) is an anti-emetic and a pro-kinetic agent. It is one of many active ingredients of pharmaceutical preparations concerned with gastroenterology, surgery, gynaecology, and cardiology. Moreover, MCP-HCl is widely used in the treatment of drug-induced nausea and vomiting, including anti-cancer drugs. MCP-HCl, [monohydrate of 4-amino-5-chloro-N-(2-diethyl-aminoethyl)-2-methoxy benzamide hydrochloride], Fig. 1, is freely soluble in water and alcohol, sparingly soluble in methylene chloride and practically insoluble in ether.