Lidocaine - CAS 137-58-6

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Product Name
Catalog Number
CAS Number
Molecular Weight
Molecular Formula
CAS 137-58-6 Lidocaine
White or off-white crystalline powder
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Reference Reading
1. A novel electrochemical sensor for the determination of lidocaine based on surface-imprinting on porous three-dimensional film
Guangming Yang and Faqiong Zhao*. J. Mater. Chem. C,2014, 2, 10201–10208
The results indicated that in the presence of 100-fold glucose, ascorbic acid, uric acid and glutamic acid did not affect the detection of lidocaine (1.0 × 10-6mol L-1, signal change below 5%). At the same time, the influence of similar compounds (i.e. ropivacaine and bupivacaine) was also investigated. As a result, 1.0 ×10-6mol L-1 lidocaine caused an obvious response at the MIP sensor, but in the presence of 20-fold ropivacaine and bupivacaine had almost no response. When lidocaine and similar compounds coexisted, the response current was similar to that caused by only lidocaine, which was ascribed to the effect of MIP.
2. Ionic conjugates of lidocaine and sweeteners as better tasting local anesthetics for dentistry
Iryna O. Lebedyeva, Alexander A. Oliferenko,* J. Mater. Chem. B, 2015, 3, 8492—8498
Lidocaine hydrochloride is commonly used for local analgesia prior to performing painful medical procedures. In dentistry, it was found to provide effective pain control during scaling, root planning in treatment of periodontitis, and to stabilize vital signs of patients under general anesthesia during dental surgery and rehabilitation. Lidocaine hydrochloride is used for pharyngeal anesthesia before upper gastrointestinal tract endoscopy, and was shown to improve patients comfort during extensive nasal surgery. Numerous attempts have been described in the academic and patent literature to neutralize its bitter taste by formulating lidocaine hydrochloride with natural or artificial sweeteners.
3. Synthesis of novel lidocaine-releasing poly(diol-co-citrate) elastomers by using deep eutectic solvents
M. Concepcion Serrano,* Marıa C. Gutierrez, Ricardo Jimenez, M. Luisa Ferrer and Francisco del Monte*. Chem. Commun., 2012, 48, 579–581
In this article, we describe the preparation of DESs based on mixtures of 1,8-octanediol and lidocaine for the synthesis of poly(octanediol-co-citrate) elastomers (POC) loaded with lidocaine. Lidocaine is a local anesthetic consisting of a lipophilic aromatic ring and a hydrophilic amine and has been considered as an attractive anti-inflammatory compound. In our case, the DES provides not only most of the ingredients required for the synthesis (both one of the polymer precursors and the API), but also the synthetic media where: (1) the second polymer precursor (e.g. citric acid) is solubilized and (2) the reaction proceeds.
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