Levofloxacin Hydrochloride - CAS 177325-13-2

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Category
APIs
Product Name
Levofloxacin Hydrochloride
Catalog Number
177325-13-2
CAS Number
177325-13-2
Molecular Weight
397.83
Molecular Formula
C18H20FN3O4·HCl
Quality Standard
-
COA
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MSDS
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Structure
CAS 177325-13-2 Levofloxacin Hydrochloride
Specification
Purity
>89.5%
Appearance
Slightly yellow crystalline powder.
Reference Reading
1. Functional synergy of α-helical antimicrobial peptides and traditional antibiotics against Gram-negative and Gram-positive bacteria in vitro and in vivo
Q. Feng & Y. Huang & M. Chen & G. Li & Y. Chen. Eur J Clin Microbiol Infect Dis (2015) 34:197–204
Complicated skin infections, such as post-surgical and traumatic wound infections, severe carbunculosis, as well as erysipelas, are often caused by Gram-positive bacteria such as S. aureus and S. pyogenes. Levofloxacin hydrochloride was widely used in clinical applications against infections. Peptide PL-5 exhibited the best overall synergistic activity with levofloxacin hydrochloride against Gram-positive bacteria in vitro, that is, combining AMP PL-5 with levofloxacin hydrochloride produced potent synergistic effects (the FIC index was 0.078, Table S1). Thus, this drug combination was used to evaluate the antimicrobial effects, in vivo, of a mouse wound model infected with S. aureus. Based on the preliminary experiments (data not shown), mice were treated with two different doses of PL-5 and levofloxacin hydrochloride to investigate the synergistic efficacy (Table 3). The bacteriostatic rate was used to evaluate the antimicrobial efficacy.
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