|Description||(+)-Ketoconazole, an imidazole anti-fungal agent, has often produced features of androgen deficiency including decreased libido, gynecomastia, impotence, oligospermia, and decreased testosterone levels, in men being treated for chronic mycotic infections. (+)-Ketoconazole also is a cytochrome P450 inhibitor. (+)-Ketoconazole (KTZ), on the antischistosomal potential of these quinolines against Schistosoma mansoni infection by evaluating parasitological, histopathological, and biochemical parameters. Mice were classified into 7 groups: uninfected untreated (I), infected untreated (II), infected treated orally with PZQ (1,000 mg/kg) (III), QN (400 mg/kg) (IV), KTZ (10 mg/kg)+QN as group IV (V), HF (400 mg/kg) (VI), and KTZ (as group V)+HF (as group VI) (VII). KTZ plus QN or HF produced more inhibition (P<0.05) in hepatic CYP450 (85.7% and 83.8%) and CYT b5 (75.5% and 73.5%) activities, respectively, than in groups treated with QN or HF alone. This was accompanied with more reduction in female (89.0% and 79.3%), total worms (81.4% and 70.3%), and eggs burden (hepatic; 83.8%, 66.0% and intestinal; 68%, 64.5%), respectively, and encountering the granulomatous reaction to parasite eggs trapped in the liver.|
Terbinafine HCl inhibits squalene epoxidase, preventing biosynthesis of ergosterol.
Ciclopirox ethanolamine (Ciclopirox olamine, HOE 296) is a broad-spectrum antifungal agent working as an iron chelator.
Clotrimazole is a synthetic, antifungal and broad-spectrum derivate of imidazole. It is an antifungal medication commonly used in the treatment of fungal infect...
Voriconazole inhibits 95% of isolates at ≤1 μg/ml against 448 recent clinical mold isolates
Thifluzamide, a highly potent fungicide, could be commonly used in potatoes and rice against basidiomycete fungi.
Vibunazole is usually used as an antifungal agent.
Ascomycin, isolated from Streptomyces, suppresses immune response in vitro with IC50 of 0.55 nM for mouse mixed lymphocyte.
Posaconazole is a sterol C14ɑ demethylase inhibitor with an IC50 of 0.25 nM.
Econazole nitrate (Spectazole) is an imidazole class antifungal medication.It is used as a cream under the brand names Spectazole (United States), Ecostatin (Ca...
Ciclopirox olamine (used in preparations called Batrafen, Loprox, Rejuvenail, Mycoster, Penlac and Stieprox) is a synthetic antifungal agent for topical dermato...
Ethacridine lactate monohydrate
Ethacridine lactate monohydrate is an aromatic organic compound based on acridine used as an antiseptic agent.
Miconazole is an imidazole antifungal agent, developed by Janssen Pharmaceutica, commonly applied topically to the skin or to mucous membranes to cure fungal in...
Luliconazole is an azole antifungal indicated for the topical treatment of interdigital tinea pedis.
Itraconazole, a triazole antifungal agent, is a relatively potent inhibitor of CYP3A4.
Nystatin, which belongs to the polyene group of antimycotics, is frequently used as a topical agent in the treatment of oro-pharyngeal candidosis.
Cercosporamide, a natural antifungal phytotoxin, has been found to be a selective Mnk inhibitor and shows probable antileukemic effects.
Tioconazole is an antifungal medication of the imidazole class used to treat infections caused by a fungus or yeast, with an average IC50 of 1.7 μM.
Anidulafungin, is a semisynthetic echinocandin that inhibits glucan synthase, an enzyme important in the formation of (1→3)-β-D-glucan, a major fungal cell wall...
Fenticonazole Nitrate is an azole antifungal agent.
Fluconazole (mesylate) is the mesylate salt form of fluconazole, which is a triazole antifungal intended for oral treatment of superficial and systemic mycoses....