isopropyl isothiocyanate - CAS 2253-73-8
Catalog number: 2253-73-8
Category: Main Product
Molecular Formula:
Molecular Weight:
Colorless liquid
2-ISOTHIOCYANATO-PROPANE; IPNCS; ISOPROPYL ISOTHIOCYANATE; ISOTHIOCYANIC ACID ISOPROPYL ESTER; Propane, 2-isothiocyanato-; Isopropyl isothiocyanate, 95+%; Isothiocyanato-2-propane
Boiling Point:
1.Carbene-mediated transformations of 1-(benzylideneamino)benzimidazoles.
Katritzky AR1, Jishkariani D, Sakhuja R, Hall CD, Steel PJ. J Org Chem. 2011 May 20;76(10):4082-7. doi: 10.1021/jo200088s. Epub 2011 Apr 11.
Carbene-mediated transformations of N-(3-butylbenzimidazol-3-ium-1-yl)-1-arylmethanimine iodides with carbon disulfide and benzoyl isothiocyanate gave the corresponding NHC·CS(2) betaines in 68-85% and benzoyl-[1-butyl-3-[(E)-(aryl)methyleneamino]benzimidazol-1-ium-2-carbothioyl]azanides, respectively, in 74-85% yields. However, reaction with excess isopropyl isothiocyanate in NaH/THF at room temperature yielded the 1-butyl-1',3'-diisopropyl-3-[(E)-(aryl)methyleneamino]spiro[benzimidazole-2,5'-imidazolidine]-2',4'-dithiones (74-77%).
2.Antimutagenic thio compounds from Sisymbrium officinale.
Di Sotto A1, Di Giacomo S, Vitalone A, Nicoletti M, Mazzanti G. J Nat Prod. 2012 Dec 28;75(12):2062-8. doi: 10.1021/np300244q. Epub 2012 Nov 29.
Glucoputranjivin (1) and isopropyl isothiocyanate (2) were isolated from an aqueous dry extract of Sisymbrium officinale and were identified by spectroscopic analysis. The antimutagenic activity of these compounds was evaluated in a bacterial reverse mutation assay using E. coli WP2, WP2uvrA, and WP2uvrA/pKM101 strains, in comparison with the extract. In the absence of the exogenous metabolic activation system S9, the thio compounds exerted antimutagenic activity against the direct-acting mutagen methyl methanesulfonate, in all strains. In the presence of S9, both thio compounds were active against the indirect mutagens 2-aminoanthracene, in WP2uvrA, and 2-aminofluorene, in WP2. The antimutagenicity seems to be due to specific mechanisms, such as the induction of the adaptive response or the excision repair system. Conversely, the inhibition of the CYP450-mediated activation of mutagens was not supported by the present results. An antimutagenic effect was also observed for the S.
3.Determination of volatile glucosinolate degradation products in seed coat, stem and in vitro cultures of Moringa peregrina (Forssk.) Fiori.
Dehshahri S1, Afsharypuor S, Asghari G, Mohagheghzadeh A. Res Pharm Sci. 2012 Jan;7(1):51-6.
Moringaceae, a monogeneric family in Capparales (glucosinolate-containing species), includes 14 species. One of them is Moringa peregrina (Forssk.) Fiori., a small tree, which grows in south east of Iran. Volatile constituents of seed coat and stem of M. peregrina were determined by GC and GC/MS. Moreover, extracts of seed and different cultured cells were analyzed by TLC and GC. Three volatile isothiocyanates including isopropyl isothiocyanate (4.2%), sec-butyl isothiocyanate (< 0.1%) and isobutyl isothiocyanate (92.9%) were found in the volatile oil of the stem , while only two volatile isothiocyanates namely isopropyl isothiocyanate (7.0%) and isobutyl isothiocyanate (51.5%) were determined in the seed coat of the tree. For the first time, the callus and suspension cultures of M. peregrina were initiated and established successfully on Murashige and Skoog medium, containing plant growth hormones. Different precursors and elicitors were fed to the cultures to induce glucosinolates production.
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CAS 2253-73-8 isopropyl isothiocyanate

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