1. Halogen bonded complexes between volatile anaesthetics (chloroform, halothane, enﬂurane, isoﬂurane) and formaldehyde: a theoretical study
Wiktor Zierkiewicz,* Robert Wieczorek, Pavel Hobzacd and Danuta Michalskaa. Phys. Chem. Chem. Phys., 2011, 13, 5105–5113
Anaesthesia is a reversible phenomenon and general anaesthetics act by perturbing weak intermolecular interactions without breaking or forming covalent bonds. Despite the fact that volatile anaesthetics, such as chloroform, halothane, enﬂurane and isoﬂurane, have been used clinically, the mechanism of their action is still not fully understood. They may act by a direct bonding to neuroreceptors. Sandorfy reported that they can form weak van der Waals complexes or intermolecular hydrogen bonds, and the strength of these interactions is in the range between 1.0 and 2.2 kcal mol-1. Investigation of the halogen bonds and hydrogen bonds may help to explain anaesthetic properties of polyhalogenated alkanes and ethers. A number of experimental and theoretical evidences conﬁrm that the halogen bond plays an important role in a wide variety of biological phenomena such as protein–ligand complexation.