|Synonyms||6-hydroxymethylacylfulvene; hydroxymethylacylfulvene; MGI 114; MGI-114.|
|Description||Irofulven is a semisynthetic sesquiterpene derivative of illudin S, a natural toxin isolated from the fungus Omphalotus illudens. Irofulven alkylates DNA and protein macromolecules, forms adducts, and arrests cells in the S-phase of the cell cycle. This a|
Non-selective K+ channel blocker.
Delsoline is a hypotensive alkaloid isolated from Aconitum.
Diazoxide is a potassium channel activator that causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. The cellular rel...
Synthetic, nicotinic AChR. Rigid bicyclic analog of TMA and TEA.
A muscarinic receptors antagonist.
Synthetic.alkaloid, a neuronal nicotinic AChR antagonist. Ganglioblocker.
Nudicauline is extracted from plants of the Ranunculaceae family, a Alpha-Bungarotoxin neuronal nicotinic receptor.
A substance which inhibits cholinesterases reversibly. Alkaloid , from plants of the Zygophyllaceae family
Potent antagonist for α7-containing neuronal nicotinic receptors (Ki = 1.4 nM). Interacts with α4β2 and α6β2 receptors at concentrations > 40 nM. Attenuates MET...
Dantrolene sodium is a postsynaptic muscle relaxant that lessens excitation-contraction coupling in muscle cells. It achieves this by inhibiting Ca2+ ions relea...
ShK – Stichodactyla toxin
ShK (Stichodactyla helianthus Neurotoxin) has been isolated from the venom of the Carribean sea anemone Stoichactis helianthus. ShK inhibits voltage-dependent p...
Lignan , from plants of the Rutaceae family, a substance presenting an estrogenic activity and sedative effects. .
Gramine is a naturally occurring indole alkaloid present in several plant species. Gramine may play a defensive role in these plants, since it is toxic to many ...
An antineoplastic alkaloid from Colchicum autumnale L. isolated from Colchicum autumnale L.
Nitrodienamine, an inhibitor of Ca2+/Mg2+ ATPase.
C20-diterpenoid alkaloid from plants of the Aconitum genus, Ranunculaceae. Adrenergic and Serotonergic stimulant; CNS stimulant; antiarrhythmic.
A spasmolytic agent, shows pharmacol. props. similar to 2-(Methylamino)-1-phenyl-1-propanol BCJ45-G.
M2 muscarinic receptor antagonist; myorelaxant. Steroid alkaloid derivative of Imperialine from the plant Petilium eduardi, and P. raddeanae.
Alkaloid from reticuline and is a precursor of berberine.It has also been found to be a GABAA receptor agonist.
Ionotropic GABAA receptors are ligand-gated ion channels that facilitate the passing of chloride ions across the cell membrane and promote an inhibitory influen...