(-)-Indolactam V - CAS 90365-57-4
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
(-)-Indolactam V
Catalog Number:
90365-57-4
Synonyms:
(2S-(2R*,5R*))-ethyl)-1-methyl-2-(1-methylethyl);3h-pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one,1,2,4,5,6,8-hexahydro-5-(hydroxym;(2S,5S)-1,2,4,5,6,8-Hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3H-pyrrolo[4,3,2-gh]-1,4-benzodiazonin-3-one;3H-Pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one, 1,2,4,5,6,8-hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-, (2S-(2R*,5R*))-;Indolactam V
CAS Number:
90365-57-4
Description:
(-)-Indolactam V is an indole alkaloid compound which activates protein kinase C (PKC), which strongly directs human ES cell-derived definitive endoderm into pancreatic endoderm. It is weak tumor promoter. It binds to PKC regulatory domains of mouse skin PKCη and rat brain PKCγ with Ki values of 3.4 nM and 1 μM, respectively. It induces differentiation of human embryonic stem cells into pancreatic progenitors through activation of PKC signaling at 1 μM. It may be used as an effective diabetes therapy. It may share an RA-dependent signaling pathway, allowing ultimately to streamline the process of efficient pancreatic endoderm derivation. It was predicted to be a biosynthetic intermediate and was confirmed via in vitro prenylation by LtxC due to the structural relatedness of the lyngbyatoxins and teleocidin. It induces differentiation of a substantial number of Pdx1-expressing cells from human ESCs.
Molecular Weight:
301.38
Molecular Formula:
C17H23N3O2
Quantity:
Milligrams-Grams
Quality Standard:
In-house standard
COA:
Inquire
MSDS:
Inquire
Canonical SMILES:
CC(C)C1C(=O)NC(CC2=CNC3=C2C(=CC=C3)N1C)CO
InChI:
InChI=1S/C17H23N3O2/c1-10(2)16-17(22)19-12(9-21)7-11-8-18-13-5-4-6-14(15(11)13)20(16)3/h4-6,8,10,12,16,18,21H,7,9H2,1-3H3,(H,19,22)/t12-,16-/m0/s1
InChIKey:
LUZOFMGZMUZSSK-LRDDRELGSA-N
Targets:
PKC
Chemical Structure
CAS 90365-57-4 (-)-Indolactam V

Related PKC Products


CAS 169939-93-9 Ruboxistaurin Hydrochloride

Ruboxistaurin Hydrochloride
(CAS: 169939-93-9)

Ruboxistaurin, also called as LY 333531, initially developed for the treatment of diabetic retinopathy, inhibits isolated enzymes PKCβI and PKCβII with a half-m...

CAS 75567-37-2 Ingenol Mebutate

Ingenol Mebutate
(CAS: 75567-37-2)

Ingenol Mebutate is a substance found in the sap of the plant Euphorbia peplus and an inducer of cell death. It is effective for field treatment of actinic kera...

CAS 60857-08-1 Prostratin

Prostratin
(CAS: 60857-08-1)

Prostratin is an activator of protein kinase C (PKC) and also an activator of nuclear factor KB (NF-KB) mediated through activation of the IKKs (IKB kinases). I...

CAS 425637-18-9 Sotrastaurin

Sotrastaurin
(CAS: 425637-18-9)

Sotrastaurin, also known as AEB-701, is an orally available pan-protein kinase C (PKC) inhibitor with potential immunosuppressive and antineoplastic activities....

CAS 138489-18-6 Ro 31-8220 Mesylate

Ro 31-8220 Mesylate
(CAS: 138489-18-6)

Ro 31-8220 inhibits rat brain PKC activity with IC50 of 23 nM, and does not show any high degree of selectivity between PKC-α, PKC-β, PKC-γ, and PKC-ε.

CAS 87745-28-6 Bryostatin 2

Bryostatin 2
(CAS: 87745-28-6)

Bryostatin 2, an analog of Bryostatin 1, is an activator of PKC (protein kinase C) with anti-tumor properties. Bryostatin 2 inhibits DNA synthesis at 100 nM in ...

CAS 193620-69-8 TAS-301

TAS-301
(CAS: 193620-69-8)

TAS-301 is a potent and selective constrictive remodeling regulator on renarrowing after balloon overstretch injury of porcine coronary artery. TAS-103 inhibits...

CAS 118072-93-8 Zoledronic Acid

Zoledronic Acid
(CAS: 118072-93-8)

Zoledronic acid induces apoptosis in osteoclasts by inhibiting enzymes of the mevalonate pathway and preventing the isoprenylation of small GTP-binding proteins...

CAS 169939-94-0 Ruboxistaurin

Ruboxistaurin
(CAS: 169939-94-0)

Ruboxistaurin, also called as LY 333531, initially developed for the treatment of diabetic retinopathy, inhibits isolated enzymes PKCβI and PKCβII with a half-m...

CAS 170364-57-5 Enzastaurin

Enzastaurin
(CAS: 170364-57-5)

Enzastaurin HCL is the hydrochloride salt of enzastaurin, a synthetic macrocyclic bisindolemaleimide with potential antineoplastic activity. Binding to the ATP-...

CAS 37558-16-0 Phorbol 12,13-dibutyrate

Phorbol 12,13-dibutyrate
(CAS: 37558-16-0)

Phorbol 12,13-dibutyrate, a protein kinase C activator, stimulates the phosphorylation of Na+,K+- ATPase, thereby inhibiting its activity.

NSC305787
(CAS: 785718-37-8)

NSC305787 is a small molecule inhibitor of PKC. Its IC50 value is 8.3 μM, 9.4 μM, 55 μM for PKCΙ phosphorylation of recombinant ezrin, moesin and radixin. It is...

PKC-IN-1
(CAS: 1046787-18-1)

PKC-IN-1 has been found to be a PKCβII inhibitor that probably has biological activity in antineoplastic studies. Ki: 14.9 nM.

CAS 163751-35-7 rac-3-Hexadecanamido-2-methoxypropan-1-ol Phosphocholine Monohydrate

rac-3-Hexadecanamido-2-methoxypropan-1-o
(CAS: 163751-35-7)

The Pharmacological activity of this molecular is Growth Inhibition of Malignant Cells in vivo and in vitro and cytotoxic properties may result inhibition of pr...

CAS 62996-74-1 Staurosporine

Staurosporine
(CAS: 62996-74-1)

Staurosporine is broad spectrum protein kinase inhibitor. Enzymes inhibited include protein kinase C (IC50 = 3 nM), protein kinase A (IC50 = 7 nM), p60v-src tyr...

CAS 165800-06-6 Zoledronic acid monohydrate

Zoledronic acid monohydrate
(CAS: 165800-06-6)

Zoledronic acid (zoledronate) is a bisphosphonate bone resorption inhibitor, an inhibitor of farnesyl diphosphate (FPP) synthase which results in downstream inh...

CAS 17673-25-5 Phorbol

Phorbol
(CAS: 17673-25-5)

Phorbol, derived from the roots of Euphorbia pekinensis Rupr., as a tumor promoter it is able to activate protein kinase C.

CAS 133053-19-7 Go6983

Go6983
(CAS: 133053-19-7)

GO6983 is a potent protein kinase C (PKC) inhibitor. GO6893 displays cardioprotective properties; reduces polymorphonuclear leukocyte adherence and infiltration...

CAS 125314-64-9 RO31-8220

RO31-8220
(CAS: 125314-64-9)

Ro 31-8220 is a PKC-inhibitor, which inhibits stimulated fluid pinocytosis of human PMNs induced by the PKC-activators phorbol myristate acetate or diacylglycer...

NSC305787 hydrochloride
(CAS: 53868-26-1)

NSC305787 hydrochloride is a small molecule inhibitor of PKC (IC50=8.3 μM) that directly inhibits ezrin protein as an approach to prevent tumor metastasis.