Not Intended for Therapeutic Use. For research use only.

Hernandezine - CAS 6681-13-6

Quick Inquiry

Name:
* Email:
* Service & Products of Interest:
* Quantity:
* Verification code:
Please input "bocsci" as verification code.
Category
ADCs
Product Name
Hernandezine
Catalog Number
6681-13-6
CAS Number
6681-13-6
Description
Anti-tumor effect of hernandezine and other components extracted from Thalictrum glandulosissimum.
Molecular Weight
652.78
Molecular Formula
C39H44N2O7
COA
Inquire
MSDS
Inquire
Tag
ADCs Cytotoxin
Structure
CAS 6681-13-6 Hernandezine
Specification
Purity
95 % (TLC).
Melting Point
192-193 °C
Appearance
Solid Powder
Application
ADCs Cytotoxin
Storage
Store at +4 °C, in dark place.
Solubility
Chloroform; not well in ethanol, methanol.
Related ADCs Cytotoxin Products
  • CAS 228266-41-9 Taltobulin trifluoroacetate

    Taltobulin trifluoroacetate
    (CAS: 228266-41-9)

    Taltobulin trifluoroacetate (HTI-286; SPA-110) is an analogue of Hemiasterlin; potent tubulin inhibitor; ADCs cytotoxin.

  • CAS 1953-04-4 Galanthamine hydrobromide

    Galanthamine hydrobromide
    (CAS: 1953-04-4)

    Long-acting, centrally active acetylcholinesterase inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. Prevents β-amyloid-...

  • H-Glutaned
    (CAS: 148822-93-9)

    The lanthanide element from Glutaned replaces calcium in its complex with prothrombine,<br/>thus preventing the formation of thrombine and interrupting the bloo...

  • M5-Nitrodienamine
    (CAS: )

    Nitrodienamine, an inhibitor of Ca2+/Mg2+ ATPase.

  • CAS 145808-47-5 Margatoxin

    Margatoxin
    (CAS: 145808-47-5)

    Margatoxin (MgTx) is a component of the venom of Scorpio Centruroides margaritatus. Margatoxin preferentially inhibits voltage-dependent potassium channels Kv1....

  • CAS 6164-47-2 Protopine hydrochloride

    Protopine hydrochloride
    (CAS: 6164-47-2)

    Protopine is a benzylisoquinoline alkaloid occurring in opium poppy, Corydalis tubers and other plants of the family papaveraceae, like Fumaria officinalis. It ...

  • CAS 105029-41-2 Argiotoxin

    Argiotoxin
    (CAS: 105029-41-2)

    Argiotoxin blocks the glutamate responses and sensorimotor transmission in motoneurones of isolated frog spinal cord.

  • CAS 477-30-5 Colcemide

    Colcemide
    (CAS: 477-30-5)

    An antineoplastic alkaloid from Colchicum autumnale L. isolated from Colchicum autumnale L.

  • CAS 54527-84-3 Nicardipine Hydrochloride

    Nicardipine Hydrochloride
    (CAS: 54527-84-3)

    Dihydropyridine calcium channel blocker. Antianginal; antihypertensive.

  • CAS 22352-41-6 Hippeastrine hydrobromide

    Hippeastrine hydrobromide
    (CAS: 22352-41-6)

    Amaryllidaceae alkaloid from plants of the Amaryllidaceae family. A hypotensive, sedative. Amaryllidaceae alkaloid , from plants of the Amaryllidaceae family.

  • CAS 36101-54-9 Peganole

    Peganole
    (CAS: 36101-54-9)

    Derivative of Desoxypeganine from plants of the Zygophyllaceae family, a psychotomimetic agent on dogs and cats; acetylcholinesterase inhibitor.

  • CAS 75433-28-2 Laticauda semifasciata III

    Laticauda semifasciata III
    (CAS: 75433-28-2)

    Polypetide, an antagonist of the nicotinic acetylcholine receptor at the neuromuscular junction with a weaker affinity to the receptor than Erabutoxins a and b.

  • Polyprenols
    (CAS: 308068-00-0)

    Polyprenols are natural long-chain isoprenoid alcohols of the general formula H-(C5H8)n-OH where n is the number of isoprene units. Any prenol with more than 4 ...

  • CAS 345-78-8 Pseudoephedrine Hydrochloride

    Pseudoephedrine Hydrochloride
    (CAS: 345-78-8)

    alpha and beta Adrenoreceptors subtypes agonist; MAO inhibitor. Alkaloid derivative of (+)-Pseudoephedrine from plants of the Ephedra genus, Ephedraceae.

  • CAS 20180-95-4 Scoulerin hydrochloride

    Scoulerin hydrochloride
    (CAS: 20180-95-4)

    Alkaloid from reticuline and is a precursor of berberine.It has also been found to be a GABAA receptor agonist.

  • alpha-Short neurotoxin
    (CAS: )

    α-Neurotoxins from snake venoms that tightly bind nAChRs contain 60-75 amino acid (aa) residues and are linked by 4-5 disulfide bridges. an antagonist of the ni...

  • CAS 50-98-6 (-)-Ephedrine hydrochloride

    (-)-Ephedrine hydrochloride
    (CAS: 50-98-6)

    alpha and beta Adrenoreceptors subtypes agonist; MAO inhibitor. Alkaloid derivative of l-Ephedrine from plants of the Ephedra genus, Ephedraceae.

  • CAS 9083-23-2 Erabutoxin B

    Erabutoxin B
    (CAS: 9083-23-2)

    an antagonist of the nicotinic acetylcholine receptor at the neuromuscular junction. Erabutoxin B from Laticauda semifasciata (Sea Snake)

  • CAS 41743-44-6 Ferutinine

    Ferutinine
    (CAS: 41743-44-6)

    Estrogenic activity; half agonist of estradiol receptors. Complex esters of phenolcarbon acids, , from plants of the Ferula genus, Umbelliferae.

  • Auristatin T
    (CAS: 1799603-53-4)

    A microtubule-disrupting agent.

Reference Reading
1.Inhibitory effects of tetrandrine and hernandezine on Ca2+ mobilization in rat glioma C6 cells.
Imoto K1, Takemura H, Kwan CY, Sakano S, Kaneko M, Ohshika H. Res Commun Mol Pathol Pharmacol. 1997 Feb;95(2):129-46.
The effects of tetrandrine (TET), a Ca2+ antagonist of Chinese herbal origin, and hernandezine (HER), a structural analogue of TET, on Ca2+ mobilization were studied in rat glioma C6 cells. TET and HER alone did not affect the resting cytoplasmic Ca2+ concentration ([Ca2+]i). TET and HER inhibited the peak and sustained elevation of [Ca2+]i induced by bombesin and thapsigargin (TG), a microsomal Ca2+ ATPase inhibitor, in a dose-dependent manner. The doses of TET or HER needed to abolish the sustained and peak increase in [Ca2+]i induced by bombesin and TG were 30 microM and 300 microM, respectively. TET and HER did not increase inositol 1,4,5-trisphosphate (IP3) accumulation by themselves but inhibited IP3 accumulation elevated by bombesin. In permeabilized C6 cells, the addition of IP3 and TG released Ca2+ from intracellular stores. Pretreatment with TET or HER abolished Ca2+ release from intracellular stores induced by bombesin and TG.
2.Hernandezine, a novel AMPK activator induces autophagic cell death in drug-resistant cancers.
Law BY1, Mok SW1, Chan WK1, Xu SW1, Wu AG1, Yao XJ1, Wang JR1, Liu L1, Wong VK1. Oncotarget. 2016 Feb 16;7(7):8090-104. doi: 10.18632/oncotarget.6980.
Drug resistance hinder most cancer chemotherapies and leads to disease recurrence and poor survival of patients. Resistance of cancer cells towards apoptosis is the major cause of these symptomatic behaviours. Here, we showed that isoquinoline alkaloids, including liensinine, isoliensinine, dauricine, cepharanthine and hernandezine, putatively induce cytotoxicity against a repertoire of cancer cell lines (HeLa, A549, MCF-7, PC3, HepG2, Hep3B and H1299). Proven by the use of apoptosis-resistant cellular models and autophagic assays, such isoquinoline alkaloid-induced cytotoxic effect involves energy- and autophagy-related gene 7 (Atg7)-dependent autophagy that resulted from direct activation of AMP activated protein kinase (AMPK). Hernandezine possess the highest efficacy in provoking such cell death when compared with other examined compounds. We confirmed that isoquinoline alkaloid is structurally varied from the existing direct AMPK activators.
3.Plant alkaloids, tetrandrine and hernandezine, inhibit calcium-depletion stimulated calcium entry in human and bovine endothelial cells.
Low AM1, Berdik M, Sormaz L, Gataiance S, Buchanan MR, Kwan CY, Daniel EE. Life Sci. 1996;58(25):2327-35.
Depletion of internal Ca2+ stores causes capacitative Ca2+ entry which occurs through non-selective cation channels sensitive to blockade by SK&F 96365. Recently, alkaloids of Chinese herbal medicinal origin, tetrandrine and hernandezine, have been shown to possess actions including inhibition of Ca2+ channels in non-excitable cell types. In this study, we compared the actions of these novel inhibitors to those of SK&F 96365 in fura-2-loaded endothelial cells from human umbilical vein and bovine pulmonary artery. Depletion of Ca2+ from the internal stores was accomplished in Ca(2+)-free medium using an endoplasmic reticulum Ca2+ pump inhibitor, cyclopiazonic acid (CPA) or receptor agonists, histamine and bradykinin. Stimulation with histamine or bradykinin caused a marked and rapid transient increase in Ca2+ signal whereas CPA caused a smaller amplitude increase of longer duration. Restoring Ca2+ to the medium caused marked and sustained increases in the fluorescence indicating movement of Ca2+ into the cytosol presumably stimulated by the emptied Ca2+ stores.
2005 - BOC Sciences | All rights reserved
BOCSciences
X CLOSE
BOCSciences
X CLOSE
BOCSciences
X CLOSE
BOCSciences
X CLOSE
BOCSciences
X CLOSE
BOCSciences
X CLOSE
BOCSciences
X CLOSE
BOCSciences
X CLOSE
BOCSciences
X CLOSE
BOCSciences
X CLOSE
BOCSciences
X CLOSE
BOCSciences
X CLOSE
BOCSciences
X CLOSE
BOCSciences
X CLOSE
BOCSciences
X CLOSE
BOCSciences
X CLOSE
BOCSciences
X CLOSE
BOCSciences
X CLOSE
BOCSciences
X CLOSE
BOCSciences
X CLOSE
BOCSciences
X CLOSE
BOCSciences
X CLOSE
BOCSciences
X CLOSE
BOCSciences
X CLOSE
DOWNLOAD