A Na+ channel blocker; potent antiarrhythmic, inhibits voltage-gated Na+ channels in rat brain synaptosomes.
Synthetic, nicotinic AChR. Rigid bicyclic analog of TMA and TEA.
Alkaloid , from plants of the Ranunculaceae family. Ganglioblocker; nicotinic receptor antagonist; hypotensive; presents micromolar affinity at brain a Bungarot...
Monomethyl Auristatin E (MMAE) is a synthetic analog of dolastatin 10 that similarly inhibits tubulin polymerization and exhibits potent cytotoxicity. It is com...
7-Epi 10-Desacetyl Paclitaxel
7-Epi 10-Desacetyl Paclitaxel is a derivative of Paclitaxel, which is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.
Irofulven is a semisynthetic sesquiterpene derivative of illudin S, a natural toxin isolated from the fungus Omphalotus illudens. Irofulven alkylates DNA and pr...
Gossypol Acetic Acid
an antiviral at low concentration; antiherpes, antipsoriasis and antikeratitis, male contraceptive. Polyphenol , from plants of the Gossypium genus, Malvaceae.
Camptothecin (CPT) is a potent DNA enzyme topoisomerase I (topo I) inhibitor with an IC50 and IC70 of 50 nM and 0.225 μM for breast cancer cell line MDA-MB-231.
Extract from plants of the Leguminosae family, an antiatherosclerotic and angioprotective, reduces platelet aggregation.
Tubulysin B is a cytotoxic agent, used as the cytotoxic component in antibody-drug conjugates.
Quinoline alkaloid, extracted from Haplophyllum bucharicum (Rutacae)
Steroidal Alkaloid from Convolvulus krauseanus
Synthetic, a potent inhibitor of high-affinity choline uptake (HAChU) in synaptosomes.
Melamine is a widely used, broad-spectrum benzimidazole fungicide and a metabolite of benomyl. It is also employed as a casting worm control agent in amenity tu...
Monomethyl auristatin F (MMAF) is a synthetic antineoplastic agent. It is part of some experimental anti-cancer antibody-drug conjugates such as vorsetuzumab ma...
A scorpion alpha-insect toxin, which prolongs the evoked action potential by an inhibition of sodium current inactivation in insects and mammals.
Chlorotoxin (Cltx) is a neurotoxin that was originally isolated from the venom of Leiurus quinquestriatus. Chlorotoxin is a specific ligand of glioma cells. Chl...
Melittin inhibits protein kinase C, Ca2+/calmodulin-dependent protein kinase II, myosin light chain kinase and Na+/K+-ATPase (synaptosomal membrane) and is a ce...
Synthetic, a selective irreversible inhibitor of carboxylesterases
A potent non-competitive GABA antagonist in mammalian, molluscan and insects; convulsant;laboratory insecticide.