FLORIFENINE - CAS 83863-79-0
Catalog number: 83863-79-0
Category: Main Product
Molecular Formula:
C23H22F3N3O2
Molecular Weight:
429.43
COA:
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Purity:
95%
Synonyms:
2-[[7-(Trifluoromethyl)-4-quinolinyl]amino]benzoic Acid 2-(1-Pyrrolidinyl)ethyl Ester;
MSDS:
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Application:
A novel anti-inflammatory agent.
Boiling Point:
535.9ºC at 760 mmHg
Density:
1.315g/cm3
1.A study of the novel anti-inflammatory agent florifenine topical anti-inflammatory activity and influence on arachidonic acid metabolism and neutrophil functions.
Bustos G1, Ferrándiz ML, Sanz MJ, Payá M, Alcaraz MJ. Naunyn Schmiedebergs Arch Pharmacol. 1995 Mar;351(3):298-304.
We have evaluated the effects of the novel anti-inflammatory agent florifenine, 2-(1-Pyrrolidinyl)ethyl N-[7-(trifluoromethyl)-4-quinolyl]anthranilate, on topical inflammation in mice, free radical-mediated reactions, arachidonic acid metabolism and some neutrophil functions. Topical administration of florifenine produced dose-related anti-inflammatory activity in 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ear oedema and with a lower potency, in the response induced by arachidonic acid (AA). Florifenine also inhibited neutrophil migration and PGE2 content in the inflammed ears. In human whole blood, florifenine was a potent and selective inhibitor of TXB2 generation. This anti-inflammatory agent did not exert antioxidant effects but inhibited elastase release in human neutrophils without affecting superoxide anion generation. Florifenine administration to mice dose-dependently inhibited leukocyte migration and PGE2 levels in the air pouch inflammation induced by zymosan.
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CAS 83863-79-0 FLORIFENINE

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