(-)-FENCHONE - CAS 4695-62-9
Catalog number: 4695-62-9
Category: Main Product
Molecular Formula:
Molecular Weight:
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(1S)-1,3,3-trimethyl-norbornan-2-one; 1,3,3-trimethyl-,(1r,4s)-(+)-2-norbornanon; 1,3,3-trimethyl-,(1S)-Bicyclo[2.2.1]heptan-2-one; 2-Norbornanone, 1,3,3-trimethyl-, (1R,4S)-(+)-; 2-Norbornanone, 1,3,3-trimethyl-, (1S,4R)-(+)-; 3,3-trimethyl-(1s)-bicyclo(2.2.
Boiling Point:
Melting Point:
0.948 g/mL at 25 °C(lit.)
1.Composition and Variability of the Essential Oil of the Flowers of Lavandula stoechas from Various Geographical Sources.
La Bella S, Tuttolomondo T, Dugo G, Ruberto G, Leto C, Napoli EM, Potorti AG, Fede MR, Virga G, Leone R, D'Anna E, Licata M. Nat Prod Commun. 2015 Nov;10(11):2001-4.
Samples of flowers of wild Lavandula stoechas L. spp. stoechas populations were collected in three areas of Sicily (Italy) and were characterized in agronomic and chemical terms. Essential oil (EO) was extracted by hydrodistillation and analyzed by GC-FID and GC-MS. GC-FID and GC-MS analyses permitted identification of 89 compounds from the EO. The samples were separated into 3 groups using PCA (Principal Component Analysis) statistical method, with reference to the chemical composition of the EO. All three Sicilian populations of lavender were identified as the fenchone chemotype with percentage content ranged between 52.8-71.1%. The population of Partinico showed the highest dry weight of flowers per plant (221.3 g), but the lowest EO yield (0.37%). The essential oils of the three wild Sicilian populations of L. stoechas L. spp. stoechas showed a greater chemical differentiation than those obtained from other Mediterranean areas.
2.Antimicrobial activity of the essential oil of Tetradenia riparia (Hochst.) Codd. (Lamiaceae) against cariogenic bacteria.
de Melo NI1, de Carvalho CE1, Fracarolli L1, Cunha WR1, Veneziani RC1, Martins CH1, Crotti AE2. Braz J Microbiol. 2015 Jun 1;46(2):519-25. doi: 10.1590/S1517-838246246220140649. eCollection 2015.
In Brazilian folk medicine, Tetradenia riparia (Hochst.) Codd. (Lamiaceae) is used to treat toothaches and dental abscesses and diseases induced by worms, bacteria, or fungi. This paper aims to investigate the chemical composition and the antibacterial effects of the essential oil obtained from Tetradenia riparia leaves (TR-EO) grown in Southeastern Brazil against a representative panel of oral pathogens. We evaluated the antibacterial activity of TR-EO in terms of the minimal inhibitory concentration (MIC). We identified aromadendrene oxide (14.0%), (E,E)-farnesol (13.6%), dronabinol (12.5%), and fenchone (6.2%) as the major constituents of TR-EO. TR-EO displayed MIC values between 31.2 and 500 μg/mL, with the lowest MIC value being obtained against Streptococcus mitis (31.2 μg/mL), S. mutans (62.5 μg/mL), S. sobrinus (31.2 μg/mL), and Lactobacillus casei (62.5 μg/mL). In time-kill experiments, TR-EO demonstrated bactericidal activity against S.
3.Simultaneous Determination of Essential Oil Components and Fatty Acids in Fennel using Gas Chromatography with a Polar Capillary Column.
Najdoska-Bogdanov M, Bogdanov JB, Stefova M. Nat Prod Commun. 2015 Sep;10(9):1619-26.
Cultivated and wild growing samples of fennel (Foeniculum vulgare Mill., Apiaceae) from R. Macedonia were studied for their volatiles and fatty acid composition. The main essential oil components isolated via hydrodistillation were: trans-anethole (>80%), estragole (< 6%), limonene (< 6%), anisaldehyde (< 1%) and 0.5 % fenchone. An alternative method for characterization of both the non-polar volatile and non volatile fractions was developed using n-hexane and dichloromethane (3:1, v/v) in a Soxhlet extraction followed by transesterification. The obtained extracts were then characterized and the dominant fatty acid was 18:1 (petroselinic and oleic acid) 75.0-82.8%, followed by 18:2 (linoleic acid) 10.8-16.2% and other fatty acids: palmitic (4.3-6.9%), stearic (1.2-1.7%) and myristic (0-2.9%). The results for the volatile fraction after Soxhlet extraction and transesterification did not significantly differ from results obtained after hydrodistillation, especially for the main components (trans-anethole, estragole, fenchone and limonene), implying that the developed method can be used for simultaneous determination of volatiles and fatty acids.
4.Enhancement of ketorolac tromethamine permeability through rat skin using penetration enhancers: An ex-vivo study.
Kumar P1, Singh SK1, Mishra DN1, Girotra P1. Int J Pharm Investig. 2015 Jul-Sep;5(3):142-6. doi: 10.4103/2230-973X.160850.
INTRODUCTION: Ketorolac tromethamine (KT), a nonsteroidal anti-inflammatory drug, when given orally causes gastrointestinal disturbances. Its transdermal drug delivery may reduce such side effects associated with them. The present investigation was aimed at evaluating the efficiency of various penetration enhancers for improved permeation of KT through the skin.
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