Ethyl mercaptoacetate;Ethyl thioglycolate - CAS 623-51-8
Catalog number: 623-51-8
Category: Main Product
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colourless liquid
Flammables area
Boiling Point:
54ºC(12 torr)
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1.Calmodulin modulates insect odorant receptor function.
Mukunda L1, Miazzi F1, Kaltofen S1, Hansson BS1, Wicher D2. Cell Calcium. 2014 Apr;55(4):191-9. doi: 10.1016/j.ceca.2014.02.013. Epub 2014 Feb 23.
Insect odorant receptors (ORs) are heteromeric complexes of an odor-specific receptor protein (OrX) and a ubiquitous co-receptor protein (Orco). The ORs operate as non-selective cation channels, also conducting Ca(2+) ions. The Orco protein contains a conserved putative calmodulin (CaM)-binding motif indicating a role of CaM in its function. Using Ca(2+) imaging to monitor OR activity we investigated the effect of CaM inhibition on the function of OR proteins. Ca(2+) responses elicited in Drosophila olfactory sensory neurons by stimulation with the synthetic OR agonist VUAA1 were reduced and prolonged by CaM inhibition with the potent antagonist W7 but not with the weak antagonist W5. A similar effect was observed for Orco proteins heterologously expressed in CHO cells when CaM was inhibited with W7, trifluoperazine or chlorpromazine, or upon overexpression of CaM-EF-hand mutants. With the Orco CaM mutant bearing a point mutation in the putative CaM site (K339N) the Ca(2+) responses were akin to those obtained for wild type Orco in the presence of W7.
2.Mutational analysis of cysteine residues of the insect odorant co-receptor (Orco) from Drosophila melanogaster reveals differential effects on agonist- and odorant-tuning receptor-dependent activation.
Turner RM1, Derryberry SL2, Kumar BN1, Brittain T1, Zwiebel LJ2, Newcomb RD3, Christie DL4. J Biol Chem. 2014 Nov 14;289(46):31837-45. doi: 10.1074/jbc.M114.603993. Epub 2014 Sep 30.
Insect odorant receptors are heteromeric odorant-gated cation channels comprising a conventional odorant-sensitive tuning receptor (ORx) and a highly conserved co-receptor known as Orco. Orco is found only in insects, and very little is known about its structure and the mechanism leading to channel activation. In the absence of an ORx, Orco forms homomeric channels that can be activated by a synthetic agonist, VUAA1. Drosophila melanogaster Orco (DmelOrco) contains eight cysteine amino acid residues, six of which are highly conserved. In this study, we replaced individual cysteine residues with serine or alanine and expressed Orco mutants in Flp-In 293 T-Rex cells. Changes in intracellular Ca(2+) levels were used to determine responses to VUAA1. Replacement of two cysteines (Cys-429 and Cys-449) in a predicted intracellular loop (ICL3), individually or together, gave variants that all showed similar increases in the rate of response and sensitivity to VUAA1 compared with wild-type DmelOrco.
3.Coloring, bleaching, and perming: influence on EtG content in hair.
Kerekes I1, Yegles M. Ther Drug Monit. 2013 Aug;35(4):527-9. doi: 10.1097/FTD.0b013e31828ca246.
BACKGROUND: Hair analysis of ethyl glucuronide (EtG) has become, beside fatty acid ethyl ester, a valuable marker for the detection of moderate and chronic excessive alcohol consumption. So far, only few studies exist about the influence of cosmetic treatment on EtG content in hair. The aim of this study was to evaluate the effect of coloring, bleaching, and perming on the concentration of this alcohol marker in hair. Studies were also performed to evaluate the chemical stability of EtG in the presence of hydrogen peroxide and ammonium thioglycolate.
4.An inhibitor of Na(+)/Ca(2+) exchange blocks activation of insect olfactory receptors.
Bobkov Y1, Corey E2, Ache B3. Biochem Biophys Res Commun. 2014 Jul 25;450(2):1104-9. doi: 10.1016/j.bbrc.2014.06.120. Epub 2014 Jul 1.
Earlier we showed that the Na(+)/Ca(2+) exchanger inhibitor, KB-R7943, potently blocks the odor-evoked activity of lobster olfactory receptor neurons. Here we extend that finding to recombinant mosquito olfactory receptors stably expressed in HEK cells. Using whole-cell and outside-out patch clamping and calcium imaging, we demonstrate that KB-R7943 blocks both the odorant-gated current and the odorant-evoked calcium signal from two different OR complexes from the malaria vector mosquito, Anopheles gambiae, AgOr48+AgOrco and AgOr65+AgOrco. Both heteromeric and homomeric (Orco alone) OR complexes were susceptible to KB-R7943 blockade when activated by VUAA1, an agonist that targets the Orco channel subunit, suggesting the Orco subunit may be the target of the drug's action. KB-R7943 represents a valuable tool to further investigate the functional properties of arthropod olfactory receptors and raises the interesting specter that activation of these ionotropic receptors is directly or indirectly linked to a Na(+)/Ca(2+) exchanger, thereby providing a template for drug design potentially allowing improved control of insect pests and disease vectors.
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CAS 623-51-8 Ethyl mercaptoacetate;Ethyl thioglycolate

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