Long-acting, centrally active acetylcholinesterase inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. Prevents β-amyloid-...
ω-agatoxin-IVA (ω-AGA IVA) is a peptide originally isolated from funnel web-spider venom Agelenopsis aperta. This peptide is a specific blocker of P/Q-type calc...
Anticoagulant: irreversible inhibits serine proteinase a-thrombine. Fluorocontaining phosphonate, synthetised.
Synthetic, a potent inhibitor of high-affinity choline uptake (HAChU) in synaptosomes.
7-Epi 10-Desacetyl Paclitaxel
7-Epi 10-Desacetyl Paclitaxel is a derivative of Paclitaxel, which is a microtubule polymer stabilizer with IC50 of 0.1 pM in human endothelial cells.
An inhibitor of the binding of [125I]-apamin to rat brain synaptosomes and a specific neurotoxicity in mice<br/>A 31 Amino-Acids peptide with 3 disulfide bonds ...
Margatoxin (MgTx) is a component of the venom of Scorpio Centruroides margaritatus. Margatoxin preferentially inhibits voltage-dependent potassium channels Kv1....
An anesthetic acting on the nerve endings, with a good selectivity on sensory nerves; lowers arterial pressure; vasodilator. Tropane alkaloid , from plants of t...
Imperialine is an isosteroidal alkaloid from Fritillaria thunbergii, a short-acting selective M2 muscarinic receptor antagonist.
An analog of Veratridine; Na+ channel activator; potent neurotoxic; depolarizing agent on membranes of nerve terminal, muscle and gland cells.
Duocarmycin SA is a cytotoxic agent, used as the cytotoxic component in antibody-drug conjugates.
Potent antagonist for α7-containing neuronal nicotinic receptors (Ki = 1.4 nM). Interacts with α4β2 and α6β2 receptors at concentrations > 40 nM. Attenuates MET...
An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin.
Monomethyl auristatin F (MMAF) is a synthetic antineoplastic agent. It is part of some experimental anti-cancer antibody-drug conjugates such as vorsetuzumab ma...
A highly active peripheral M2-cholinoblocker alkaloid. Cervane alkaloid derivative of Imperialine from the plant Petilium eduardi.
An antiarrhythmic of 1-st and 1Y classes and a blocker of TTX sensitive Na+ channels, Ca++ antagonist diterpene alkaloid from Delphinium staphisagria.
M2 muscarinic receptor antagonist; myorelaxant. Steroid alkaloid derivative of Imperialine from the plant Petilium eduardi, and P. raddeanae.
Batrachotoxin (BTX) is an extremely potent cardiotoxic and neurotoxic steroidal alkaloid found in certain species of frogs, melyrid beetles, and birds.Batrachot...
Ionotropic GABAA receptors are ligand-gated ion channels that facilitate the passing of chloride ions across the cell membrane and promote an inhibitory influen...
A scorpion alpha-insect toxin, which prolongs the evoked action potential by an inhibition of sodium current inactivation in insects and mammals.