Vinflunine is a new vinca alkaloid uniquely fluorinated with the properties of mitotic-arresting and tubulin-interacting activity.
PBOX-15 is a novel microtubule inhibitor, which induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated apoptosis in multiple myeloma cel...
ABT 751, also called E7010, is a a novel bioavailable tubulin-binding and antimitotic agent (in neuroblastoma: IC50= 0.6–2.6 μM; in non-neuroblastoma cell line...
Fosbretabulin disodium is the disodium salt of a water-soluble phosphate derivative of a natural stilbenoid phenol derived from the African bush willow (Combret...
Vinblastine is inhibitor of nAChR and can inhibit the formation of microtubule. It is a natural alkaloid isolated from the plant Vinca rosea Linn. It binds to t...
MPC 6827 hydrochloride
MPC 6827 hydrochloride, the hydrochloride salt form of verubulin, inhibits of microtubule formation (IC50 = 1.5 - 3.4 nM). in vitro: inhibits polymerization of...
Vinflunine, a semisynthetic derivative of Vinorelbine, is the first fluorinated microtubule inhibitor belonging to the Vinca alkaloids family endowed with uniqu...
Cabazitaxel increases CYP3A enzyme activities in rat hepatocytes. The mean ex-vivo human plasma protein binding of Cabazitaxel is 91.6%.
Vinblastine sulfate, also called cellblastin, derived from C. roseus, as a microtubule disrupter and antineoplastic agent, it binds tubulin and disrupts microtu...
Indibulin, also called D 24851, estabilizes tubulin polymerization (IC50 = 0.3 μM) and induces tumor cell cycle arrest and apoptosis. In vitro: blocking cell cy...
This active molecular is a tubulin polymerisation inhibitor which is applicated for solid cancer treatment. CKD-516 disruptes tubulin of the endothelial cytoske...
INDY，under the IUPAC name 1-(3-ethyl-5-hydroxy-1,3-benzothiazol-2-ylidene)propan-2-one, is a DYRK1A/B inhibitor (DYRK1B: IC50= 0.23μM; DYRKA: IC50= 0.230.24μM)....
7-xylosyltaxol is a taxol (Paclitaxel) derivative, which binds to tubulin and inhibits the disassembly of microtubules.
BNC105 is a novel compound being developed by Bionomics as a Vascular Disrupting Agent (VDA) for treatment of cancer. VDAs are drugs that disrupt the blood vess...
This active molecular is DM1 with a linker SMCC that can react with antibody to make antibody drug conjugate. DM1 is an antibody-conjugatable maytansinoid that ...
Taxol, also called Paclitaxel, derived from the bark of the Pacific yew tree, has a broad antineoplastic spectrum uused in cancer chemotherapy.It promotes and s...
Epothilone B, also called Patupilone, is a microtubule stabilization agent (EC0.01= 1.8 μM). It induces mitotic arrest at the G2-M transition in Hs578T (IC50 = ...
Flutax 1, the more soluble difluoro-fluorescein derivative with improved photostability Flutax-2, binds to the taxol microtubule binding site with high affinity...
lexibulin, also known as CYT997, is an orally bioavailable small-molecule with tubulin-inhibiting, vascular-disrupting, and potential antineoplastic activ...
Vinflunine induces apoptosis in neuroblastoma SK-N-SH cells through a postmitotic G1 arrest and a mitochondrial pathway in a concentration-dependent manner with...