Econazolum - CAS 27220-47-9

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Category
APIs
Product Name
Econazolum
Catalog Number
27220-47-9
Synonyms
1-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]imidazole Econazole Econazole Nitrate Ekonazole Gyno Pervaryl 150 Gyno Pevaril Gyno Pevaryl Gyno-Pervaryl 150 Gyno-Pevaril Gyno-Pevaryl GynoPevaril Nitrate, Econazole Pevaryl
CAS Number
27220-47-9
Description
Econazole, structurally similar to miconazole, is an effective antifungal drug.
Molecular Weight
381.68
Molecular Formula
C18H15Cl3N2O
Quantity
Data not available, please inquire.
COA
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MSDS
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Canonical SMILES
C1=CC(=CC=C1COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl
InChI
1S/C18H15Cl3N2O/c19-14-3-1-13(2-4-14)11-24-18(10-23-8-7-22-12-23)16-6-5-15(20)9-17(16)21/h1-9,12,18H,10-11H2
InChIKey
LEZWWPYKPKIXLL-UHFFFAOYSA-N
Structure
CAS 27220-47-9 Econazolum
Specification
Purity
95%
Boiling Point
533.8ºC at 760 mmHg
Melting Point
86.8ºC
Density
1.33 g/cm3
Appearance
Solid powder
Storage
Store in a cool and dry place and at 0 - 4℃ for short term (days to weeks) or -151℃ for long term (months to years).
Solubility
Soluble to100 mM in DMSO; H20 <1 mg/ml
Shelf Life
2 years
Reference Reading
1.Nano Spray Drying Technique as a Novel Approach To Formulate Stable Econazole Nitrate Nanosuspension Formulations for Ocular Use.
Maged A1, Mahmoud AA1,2, Ghorab MM3. Mol Pharm. 2016 Mar 31. [Epub ahead of print]
The effect of using methyl-β-cyclodextrin and hydroxypropyl-β-cyclodextrin as carriers for econazole nitrate nanoparticles prepared by nano spray dryer was explored in this work. Stabilizers, namely, poly(ethylene oxide), polyvinylpyrrolidone k30, poloxamer 407, Tween 80, and Cremophor EL, were used. The nano spray dried formulations revealed almost spherical particles with an average particle size values ranging from 121 to 1565 nm and zeta potential values ranging from -0.8 to -2.5 mV. The yield values for the obtained formulations reached 80%. The presence of the drug in the amorphous state within the nanosuspension matrix system significantly improved drug release compared to that for pure drug. Combination of hydroxypropyl-β-cyclodextrin with Tween 80 achieved an important role for preserving the econazole nanosuspension from aggregation during storage for one year at room temperature as well as improving drug release from the nanosuspension.
2.Econazole imprinted textiles with antifungal activity.
Hossain MA1, Lalloz A1, Benhaddou A2, Pagniez F3, Raymond M4, Le Pape P3, Simard P2, Théberge K2, Leblond J5. Eur J Pharm Biopharm. 2016 Apr;101:137-44. doi: 10.1016/j.ejpb.2016.02.003. Epub 2016 Feb 13.
In this work, we propose pharmaceutical textiles imprinted with lipid microparticles of Econazole nitrate (ECN) as a mean to improve patient compliance while maintaining drug activity. Lipid microparticles were prepared and characterized by laser diffraction (3.5±0.1μm). Using an optimized screen-printing method, microparticles were deposited on textiles, as observed by scanning electron microscopy. The drug content of textiles (97±3μg/cm(2)) was reproducible and stable up to 4months storage at 25°C/65% Relative Humidity. Imprinted textiles exhibited a thermosensitive behavior, as witnessed by a fusion temperature of 34.8°C, which enabled a larger drug release at 32°C (temperature of the skin) than at room temperature. In vitro antifungal activity of ECN textiles was compared to commercial 1% (wt/wt) ECN cream Pevaryl®. ECN textiles maintained their antifungal activity against a broad range of Candida species as well as major dermatophyte species.
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