(E)-Capsaicin - CAS 404-86-4
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
(E)-Capsaicin
Catalog Number:
404-86-4
Synonyms:
Capsaicinoids; Capsaicin; (E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide;
CAS Number:
404-86-4
Description:
Capsaicin, the major pungent ingredient found in hot red chili peppers of the genus Capsicum, suppresses the growth of several malignant cell lines.
Molecular Weight:
305.42
Molecular Formula:
C18H27NO3
Quantity:
Milligrams-Grams
Quality Standard:
Enterprise Standard/CP
COA:
Inquire
MSDS:
Inquire
Canonical SMILES:
CC(C)C=CCCCCC(=O)NCC1=CC(=C(C=C1)O)OC
InChI:
1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6+
InChIKey:
YKPUWZUDDOIDPM-SOFGYWHQSA-N
Targets:
TRP Channel
Current Developer:
Alopecia Areata
Chemical Structure
CAS 404-86-4 (E)-Capsaicin

Related TRP Channel Products


PF-4840154
(CAS: 1332708-14-1)

PF-4840154 has been foundd to be superior than Mustard Oil as a TrpA1 agonists. IC50: 97 nM and 23 nM (EC50) for hTrpA1 and rTrpA1 respectively.

CAS 68489-09-8 WS12

WS12
(CAS: 68489-09-8)

WS12 is a potent TRPM8 agonist. It acts as a cooling agent with EC50 value of 193 nM. It robustly activated TRPM8 in low micromolar concentrations, thus display...

SN 2
(CAS: 823218-99-1)

SN 2 is a novel and potent small molecule activator of TRPML3. Its EC50 value is 1.13 uM. It had a similar synergistic effect and reached up-to 10-fold enhancem...

Pyr10
(CAS: 1315323-00-2)

Pyr10, a pyrazole derivative, is a TRPC3-selective inhibitor that could be effective in the study of cellular functions. IC50: 0.72 uM and 13.08 uM for TRPC3-RO...

CAS 55224-94-7 AP18

AP18
(CAS: 55224-94-7)

AP18 is a selective Transient receptor potential A1(TRPA1) channel blocker which reversibly inhibits TRPA1 with IC50 values of 3.1 and 4.5 µM at human and mouse...

CAS 332117-28-9 TCS 5861528

TCS 5861528
(CAS: 332117-28-9)

TCS 5861528 is a selective TRPA1 blocker with IC50 values are 14.3 and 18.7μM respectively), attenuates diabetes mellitus hypersensitivity and displays antinoci...

SAR7334
(CAS: 1333210-07-3)

SAR7334, a TRPC6 inhibitor, could be valuable in studying sorts of diseases related to TRPC.

CAS 2444-46-4 Nonivamide

Nonivamide
(CAS: 2444-46-4)

Nonivamide, also called as N-Vanillylnonanamide, a synthetic analogue of Capsaicin isolated from peppers, is a VR1 (TRPV1) agonist.

CAS 501951-42-4 SB705498

SB705498
(CAS: 501951-42-4)

SB705498 is a TRPV1 antagonist for hTRPV1, antagonizes capsaicin, acid, and heat activation of TRPV1 with IC50 of 3 nM, 0.1 nM and 6 nM, shows a degree of volta...

CAS 942206-85-1 GSK1016790A

GSK1016790A
(CAS: 942206-85-1)

GSK1016790A is a novel and potent transient receptor potential vanilloid 4 (TRPV4) agonist. It has been used to demonstrate a role for TRPV4 in regulating urina...

Mavatrep
(CAS: 956274-94-5)

Mavatrep is an orally bioavailable, potent and selective TRPV1 antagonist with Ki value of 6.5 nM, which exhibits minimal effect on the enzymatic activity of CY...

MK-2295
(CAS: 878811-00-8)

MK-2295 is a potent TRPV1 antagonist. TRPV1 antagonists has the potential as analgesic and anti-inflammatory agents.

CAS 808756-71-0 ABT-102

ABT-102
(CAS: 808756-71-0)

ABT 102 is a selective transient receptor potential vanilloid 1 (TRPV1) receptor antagonist with IC50 values to be 5-7 nM. No recent reports of development iden...

CAS 659730-32-2 AMG-517

AMG-517
(CAS: 659730-32-2)

AMG-517 is a potent and selective TRPV1 antagonist, antagonizes capsaicin, proton, and heat activation of TRPV1 with IC50 of 0.76 nM, 0.62 nM and 1.3 nM.

CAS 393514-24-4 BCTC

BCTC
(CAS: 393514-24-4)

BCTC is a TRPA1 and TRPV1 antagonist that inhibits capsaicin-induced and acid-induced activation of rat TRPV1 with IC50 values of 35 and 6 nM, respectively.

PF 05105679
(CAS: 1398583-31-7)

PF-05105679 is a selective TRPM8 Antagonist with clinical efficacy in cold-related pain. IC50 value is 103 nM. It shows >100-fold selectivity for TRPM8 over a p...

CAS 472981-92-3 SB-366791

SB-366791
(CAS: 472981-92-3)

SB-366791 is a potent, and selective cinnamide TRPV1 antagonist (pA2 = 7.71 at hVR1) with IC50 of 5.7±1.2 nM.

CAS 349085-38-7 HC-030031

HC-030031
(CAS: 349085-38-7)

HC-030031 is a selective TRPA1 channel blocker that antagonizes AITC- and formalin-evoked calcium influx with IC50 of 6.2 μM and 5.3 μM respectively.

CAS 36945-98-9 Icilin

Icilin
(CAS: 36945-98-9)

Icilin is a synthetic CMR1/TRPM8 super agonist in CMR1-expressing HEK 293 cells (EC50 = 0.36 μM) more potently than menthol or low temperatures.

CAS 348575-88-2 Optovin

Optovin
(CAS: 348575-88-2)

Optovin is a reversible photoactive TRPA1 activator; stimulates human TRPA1 channels in vitro and enables repeated photoactivation of motor behaviors in wild-ty...