1.Spectroscopic evidence of a bidentate-binding of meso-2,3-dimercaptosuccinic acid on silver nanoclusters
Oksana Zaluzhna, Lyndsey Brightful, Thomas C. Allison, YuYe J. Tong*. Chemical Physics Letters 509 (2011) 148-151
DMSA itself is a very well known organic molecule that is widely used as a chelating agent for treating lead poisoning. It is also one of the most promising chelating agents in the pharmaceutical industry. Studies of DMSA in the context of nanoscience are also growing significantly because of its versatility in terms of binding to the surfaces of nanoparticles (NPs). For instance, it has been shown that in DMSA-protected iron oxide NPs the carboxylate groups interact directly with the NP surface with the remainder of the DMSA molecule cross-linked with each other via SAS bonds away from the metal center. On the other hand, it was also demonstrated, that the sulfur in Au12(DMSA)7 clusters instead of carboxylate groups, interacts directly with the Au core. Consequently, it is of both fundamental and practical importance to obtain precise information on how DMSA binds on NP surface when the former is used as the stabilizing ligand.
2.Study of the Complexation of Pb(II) with meso-2,3-Dimercaptosuccinic Acid (DMSA) and 2,3-Dimercapto-1-propanesulfonic acid (DMPS) Using a Bismuth-Bulk Rotating Disk Electrode
Maria de la Gala Morales, Cristina Arino, Jose Manuel Diaz-Cruz, Miquel Esteban. Electroanalysis 2014, 26, 1912-1919
Chelation is the current treatment for lead poisoning, in which strong thiol-containing chelators are administered for removing the lead from body by formation of strong complexes which favor its elimination through the renal pathway. Different chelating agents have been evaluated in many researches and meso-2,3-dimercapto-succinic acid (DMSA) and 2,3-dimercapto-1-propanesul-fonic acid (DMPS) are reported as the most suitable ligands for being used in the Pb(II) poisoning therapy because of their high effectiveness and low toxicity. They are usually employed in both oral and injectable forms not only for the treatment of lead poisoning, but also for dealing with the toxic effects of copper, antimonium, arsenic and mercury. The relevance of the binding processes of lead with DMSA and DMPS for human health makes necessary the characterization of these systems.
3.Electroanalytical and isothermal calorimetric study of As(III) complexation by the metal poisoning remediators, 2,3-dimercapto-1-propanesulfonate and meso-2,3-dimercaptosuccinic acid
Santiago Cavanillas, Elena Chekmeneva, Cristina Arino. Analytica Chimica Acta 746 (2012) 47-52
Arsenic toxicity and its association with human diseases such as blackfoot disease, diabetes, hypertension and some kinds ofcancers have been widely considered in the literature. It is well known that arsenic can be present in the environment as arsenate (As(V)), arsenite (As(III)), monomethylarsonic acid, dimethylarsinicacid, arsenobetaine and arsenosugar, all of which have different degrees of mobility, bioavailability and toxicity. Nowadays, arsenic can be found in certain water supplies, seafood, glues, pigments and cigarette smoke. In places where geological structure introduces arsenic in water, which includes North of Chile, Bangladesh among others, drinking water contamination is a serious problem.
Some chelating agents are used for the remediation of As poisoning. Of which sodium 2,3-dimercaptopropanesulfate (DMPS) and meso-2,3-dimercaptosuccinic acid (DMSA) are the most usual. These compounds include in their structure thiol groups that have a large capacity to complex several metals and metalloids.