Dilauryl thiodipropionate - CAS 123-28-4
Catalog number: 123-28-4
Category: Main Product
Molecular Formula:
C30H58O4S
Molecular Weight:
514.84
COA:
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Purity:
99%
Appearance:
White crystalline powder. Floats on water.
Synonyms:
3,3’-thiobis-propanoicacididodecylester; 3,3’-thiodi-propionicacididodecylester; 3,3'-Thiobis[propionic acid], didodecyl ester; 3,3'-Thiodipropanoic acid,didodecyl ester; Advastab 800; advastab800
MSDS:
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Quantity:
Data not available, please inquire.
Boiling Point:
562.911ºC at 760 mmHg
Melting Point:
40-42ºC
Density:
0.915
InChIKey:
GHKOFFNLGXMVNJ-UHFFFAOYSA-N
InChI:
InChI=1S/C30H58O4S/c1-3-5-7-9-11-13-15-17-19-21-25-33-29(31)23-27-35-28-24-30(32)34-26-22-20-18-16-14-12-10-8-6-4-2/h3-28H2,1-2H3
Canonical SMILES:
CCCCCCCCCCCCOC(=O)CCSCCC(=O)OCCCCCCCCCCCC
1.Final safety assessment of thiodipropionic acid and its dialkyl esters as used in cosmetics.
Diamante C1, Fiume MZ, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Alan Andersen F. Int J Toxicol. 2010 Jul;29(4 Suppl):137S-50S. doi: 10.1177/1091581810373150.
Dilauryl thiodipropionate (DLTDP), dicetyl thiodipropionate, dimyristyl thiodipropionate, distearyl thiodipropionate, and ditridecyl thiodipropionate are dialkyl esters of their respective alcohols and thiodipropionic acid (TDPA) used in cosmetics. Ingested DLTDP was excreted in the urine as TDPA. Single-dose acute oral and parenteral studies and subchronic and chronic repeated dose oral studies did not suggest significant toxicity. Neither DLTDP nor TDPA was irritating to animal skin or eyes and they were not sensitizers. TDPA was neither a teratogen nor a reproductive toxicant. Genotoxicity studies were negative for TDPA and DLTDP. Clinical testing demonstrated some evidence of irritation but no sensitization or photosensitization. The Cosmetic Ingredient Review Expert Panel considered that the data from DLTDP reasonably may be extrapolated to the other dialkyl esters and concluded that these ingredients were safe for use in cosmetic products that are formulated to be nonirritating.
2.Microstructure of Polymers by Tritium Autoradiography.
Moyer JD, Ochs RJ. Science. 1963 Dec 6;142(3597):1316-8.
Polystyrene, polypropylene, and polyethylene, containing tritiumlabeled additives and crystallized in thin films, were examined with autoradiographic stripping film. In the structures formed by isotactic polystyrene, tritiated atactic polymer concentrated in specific patterns in the outer regions. Polypropylene spherulites showed marked differences in the distribution of the tritiated additive, dilauryl thiodipropionate, whenever their optical properties also differed. Autoradiographs of polyethylene spherulites containing low molecular weight tritiated polyethylene exhibited concentric ring patterns similar to those observed on viewing the polymer film in a polarizing microscope.
3.Labware additives identified to be selective monoamine oxidase-B inhibitors.
Stewart J1, Drexler DM2, Leet JE3, McNaney CA2, Herbst JJ4. J Biomol Screen. 2014 Dec;19(10):1409-14. doi: 10.1177/1087057114551523. Epub 2014 Oct 8.
Plastic labware is used in all processes of modern pharmaceutical research, including compound storage and biological assays. The use of these plastics has created vast increases in productivity and cost savings as experiments moved from glass test tubes and capillary pipettes to plastic microplates and multichannel liquid handlers. One consequence of the use of plastic labware, however, is the potential release of contaminants and their resultant effects on biological assays. We report herein the identification of biologically active substances released from a commonly used plastic microplate. The active contaminants were identified by gas chromatography-mass spectroscopy as dodecan-1-ol, dodecyl 3-(3-dodecoxy-3-oxopropyl)sulfanylpropanoate, and dodecanoic acid, and they were found to be selective monoamine oxidase-B inhibitors.
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CAS 123-28-4 Dilauryl thiodipropionate

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