1.Fragrance material review on dihydroisojasmone.
Scognamiglio J1, Jones L, Letizia CS, Api AM. Food Chem Toxicol. 2012 Oct;50 Suppl 3:S600-3. doi: 10.1016/j.fct.2012.03.029. Epub 2012 Mar 17.
A toxicologic and dermatologic review of dihydroisojasmone when used as a fragrance ingredient is presented. Dihydroisojasmone is a member of the fragrance structural group ketones cyclopentanones and cyclopentenones. The common characteristic structural element of the group members is a cyclopentanone or cyclopentenone ring with a straight or branched chain alkane or alkene substituent. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for dihydroisojasmone were evaluated then summarized and includes physical properties, acute toxicity, skin irritation, skin sensitization, and genotoxicity data. A safety assessment of the entire ketones cyclopentanones and cyclopentenones will be published simultaneously with this document; please refer to Belsito et al. (2012) for an overall assessment of the safe use of this material and all ketones cyclopentanones and cyclopentenones in fragrances.