1. SEARCH FOR NEWDRUGS SYNTHESIS AND BIOLOGICAL ACTIVITY OF 9-DIALKYLAMINOETHYL-2-OXY(DIOXY)-PHENYLIMIDAZO[1,2-a]BENZIMIDAZOLES
V. A. Anisimova, A. A. Spasov. Pharmaceutical Chemistry Journal Vol. 40, No. 10, 2006
The spasmolytic properties of drugs were studied on an isolated section of the rat small intestine kept at 37°C in an aerated Tyrode solution. The muscle contractions were induced by a barium chloride solution (2 ×10 –4 g/ml) and detected with the aid of an isometric device (Ugo Basile, Italy). The spasmolytic activity was expressed in terms of the effective concentration (EC50 [mole/liter]) suppressing the level of barium-chloride-induced spasms by half. The reference drugs were dibazole and papaverine.
2. MOLECULAR-BIOLOGICAL PROBLEMS OF DRUG DESIGN AND MECHANISM OF DRUG ACTION
S. N. Koryakin, S. E. Ul’yanenko. Pharmaceutical Chemistry Journal Vol. 41, No. 3, 2007
The agents modifying the blood flow rate were the myotropic vasodilative drugs dibazole and the adrenomimetic (vasoconstrictive) drug mesatone. Dibazole was administered in a dose of 12.5 mg/kg by intraperitoneal injections 10 min after I-BSH, while mesatone was introduced in the same way in a dose of 2 mg/kg 30 min after I-BSH These doses correspond to a single dose effectively eliminating a model hypertension crisis (for dibazole) and increasing depressed arterial pressure (for mesatone).
3. Spectrophotometric Study of Scandium(III) Complexation with 2,2',3,4-Tetrahydroxy-3'-sulfo-5'-nitroazobenzene in the Presence of Papaverine, Dibazole, and Urotropine
S. R. Gadzhieva, T. I. Alieva, and F. M. Chyragov. Journal of Analytical Chemistry, 2006, Vol. 61, No. 8, pp. 740–743.
The effect of foreign ions and masking agents on the formation of binary and mixed-ligand complexes of scandium(III) was studied. It was shown that the reaction selectivity was signiﬁcantly enhanced in the presence of papaverine, dibazole, and urotropine. The developed procedures for determining scandium(III) with the reagent in the presence of papaverine, dibazole, and urotropine are highly selective. The determination of scandium as mixed-ligand complexes does not interfere with multiple amounts of alkaline and alkali-earth metals (Table 3).
4. The Influence of the Plasticizer Nature on the Selectivity of Ion-Selective Electrodes to Physiologically Active Amine Cations: Regularities and Abnormalities
V. V. Egorov, R. I. Astapovich, A. A. Bolotin. Journal of Analytical Chemistry, 2010, Vol. 65, No. 4, pp. 404–413.
Examples illustrating the validity of the above regularities for ISE reversible to cations of secondary (Dibazole) and primary (Amantadine) PAA are given below. It can be seen in Fig. 3 that, as might be expected, with an increase in the basicity of the plasticizer, the selectivity coefficients of the Dibazole-SE toBu4N+ and Вu3NH+ cations decrease; the coefficients increase for the OctN cation, and the selectivity to the secondary alkylammonium cation Am2N a little depends on the nature of the plasticizer. In going from NPOE to TEMP, the selectivity coefficient of the Dibazole-SE to the of Ambroxol cation bearing two salvation-active polar groups considerably increases, and the selectivity to the Propranolol cation capable of forming intramolecular hydrogen bond virtually does not change (see Table 3). Unexpectedly, a strong decrease of the selectivity coefficient to the Drotaverinium cation upon the replacement of NPOE with TEHP is explained by the fact that Drotaverine, being a enamin, differs in its properties from the usual secondary amines. Particularly, according to the results of quantum chemical calculations, the Drotaverinium cation forms approximately 16 kJ/mol less strong hydrogen bond with trimethyl phosphate compared to the diethylammonium cation.