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Daunorubicin Hydrochloride - CAS 23541-50-6

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Category
ADCs
Product Name
Daunorubicin Hydrochloride
Catalog Number
23541-50-6
Synonyms
RP 13057 Hydrochloride; Daunomycin; RP13057 Hydrochloride; RP-13057 Hydrochloride; Rubidomycin hydrochlorideE
CAS Number
23541-50-6
Description
Daunorubicin Hcl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM.
Molecular Weight
563.98
Molecular Formula
C27H30ClNO10
COA
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MSDS
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Targets
DNA and RNA synthesis
Structure
CAS 23541-50-6 Daunorubicin Hydrochloride
Specification
Purity
>98%
Application
ADCs Cytotoxin
Related Products
Reference Reading
1.Stability of [(N-pyrrolidine)metylene]daunorubicin in aqueous solutions
Anna Jeli ska, Justyna Uszak. React Kinet Catal Lett (2009) 98:69–75
The hydrolysis of [(N-Pyrrolidine)metylene]daunorubicin hydrochloride (PMD) involves: hydrolysis of protonated molecules of [(N-Pyrrolidine)metylene]daunorubicin hydrochloride (PMD) depending on hydrogen ions and spontaneous hydrolysis of zwitter, unprotonated and monoanions of [(N-Pyrrolidine)metylene]daunorubicin hydrochloride (PMD) under the influence of water. The components of phosphate, acetate and borate buffers do not demonstrate any catalytic effect. [(N-Pyrrolidine)metylene]daunorubicin hydrochloride (PMD) is the most stable at pH 2-4.
2.Administration of Chromium(III) and Manganese(II) as a Potential Protective Approach Against Daunorubicin-Induced Cardiotoxicity: in vitro and in vivo Experimental Evidence
Yang Liu & Debin Wang. Biol Trace Elem Res (2013) 156:253–261
Daunorubicin hydrochloride for injection was supplied by Pfizer Italia S.r.1. Cardiac myosin, prepared and determined according to the protocols of our previous study, was diluted to 0.4 μM with 0.01M Tris–HCl buffer saline (pH 7.4) containing 0.6 M KCl. CrCl3•6H2O and MnCl2•4H2O were purchased from Chinese Medicine (Group) Shanghai Chemical Reagent Company. Other chemical reagents weremade in China and were of analytical grades, and ultrapure water was used throughout the studies.
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