dasabuvir - CAS 1132935-63-7
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
dasabuvir
Catalog Number:
B0084-462255
Synonyms:
N-(6-(3-(tert-butyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)naphthalen-2-yl)methanesulfonamide
CAS Number:
1132935-63-7
Description:
Dasabuvir is an antiviral drug for the treatment of hepatitis C. It inhibits hepatitis C virus (HCV) non-nucleoside NS5B palm polymerase to suppress RNA replicase. Dasabuvir is commonly used in combination with ombitasvir/paritaprevir/ritonavir to effect on HCV type 1.
Molecular Weight:
493.578
Molecular Formula:
C26H27N3O5S
COA:
Inquire
MSDS:
Inquire
Canonical SMILES:
CC(C)(C)C1=C(C(=CC(=C1)N2C=CC(=O)NC2=O)C3=CC4=C(C=C3)C=C(C=C4)NS(=O)(=O)C)OC
InChI:
InChI=1S/C26H27N3O5S/c1-26(2,3)22-15-20(29-11-10-23(30)27-25(29)31)14-21(24(22)34-4)18-7-6-17-13-19(28-35(5,32)33)9-8-16(17)12-18/h6-15,28H,1-5H3,(H,27,30,31)
InChIKey:
NBRBXGKOEOGLOI-UHFFFAOYSA-N
Targets:
HCV
Chemical Structure
CAS 1132935-63-7 dasabuvir

Related HCV Products


Velpatasvir
(CAS: 1377049-84-7)

Velpatasvir is a selective Hepatitis C virus NS 5 protein inhibitor originated by Gilead Sciences. It has showed pan-genotypic activity and a high barrier to re...

CAS 1441674-54-9 Ledipasvir acetone

Ledipasvir acetone
(CAS: 1441674-54-9)

Against JFH1/3a-NS5A, DCV was more potent (EC(50) = 0.52 nM) than GS-5885 (EC(50) = 141 nM). DCV sensitivity was increased against JFH1/3a-NS5A-M28V (EC50 = 0.0...

CAS 865466-24-6 Narlaprevir

Narlaprevir
(CAS: 865466-24-6)

Narlaprevir is a potent, selective, orally bioavailable inhibitor of the hepatitis C virus (HCV) nonstructural protein 3 serine protease that is primarily metab...

CAS 1009119-64-5 Daclatasvir

Daclatasvir
(CAS: 1009119-64-5)

Daclatasvir, inhibits the HCV protein NS5A, and thus can be used as a drug candidate for the treatment of hepatitis C (HCV).

CAS 630420-16-5 Asunaprevir

Asunaprevir
(CAS: 630420-16-5)

Asunaprevir is a potent hepatitis C virus (HCV) non-structural protein protease inhibitor currently in Phase III clinical trials for the treatment of HCV infect...

CAS 300832-84-2 Ciluprevir

Ciluprevir
(CAS: 300832-84-2)

Ciluprevir is used experimentally in the treatment of hepatitis C. It is manufactured by Boehringer Ingelheim Pharma GmbH & Co. kg and developed under the resea...

Ravidasvir HCl
(CAS: 1303533-81-4)

Avidasvir is a second-generation Hepatitis C virus NS 5 protein inhibitor. In Sep 2016, Phase-II/III clinical trials in Hepatitis C in Malaysia was on-going.

CAS 863329-66-2 PSI-6206

PSI-6206
(CAS: 863329-66-2)

PSI-6206 (RO2433) is a selective HCV RNA polymerase inhibitor. It is the unphosphorylated parent compound of triphosphate analog PSI-7409, which is a potent inh...

CAS 36791-04-5 Ribavirin

Ribavirin
(CAS: 36791-04-5)

Ribavirin is a guanosine (ribonucleic) analog used to stop viral RNA synthesis and viral mRNA capping, thus, it is a nucleoside inhibitor.

BMS-890068

BMS-890068 is an acyclic P1 bi-cyclopropaneacylsulfonamidetripeptide that can be used as hepatitis C virus (HCV) NS3 protease inhibitor.

CAS 1190308-01-0 PSI-7976

PSI-7976
(CAS: 1190308-01-0)

PSI-7976 is an inhibitor of HCV RNA replication with EC50 value of 1.07μM. PSI-7851 is a phosphoramidate prodrug of PSI-7411 and has potent anti-hepatitis C vir...

CAS 1132935-63-7 dasabuvir

dasabuvir
(CAS: 1132935-63-7)

Dasabuvir is an antiviral drug for the treatment of hepatitis C. It inhibits hepatitis C virus (HCV) non-nucleoside NS5B palm polymerase to suppress RNA replica...

CAS 63968-64-9 Artemisinin

Artemisinin
(CAS: 63968-64-9)

Artemisinin is a drug used to treat multi-drug resistant strains of falciparum malaria.

CAS 923590-37-8 Vaniprevir

Vaniprevir
(CAS: 923590-37-8)

Vaniprevir is a non-covalent competitive inhibitor of the hepatitis C virus (HCV) NS3/4A protease. It is a macrocyclic hepatitis C virus NS3/4a protease inhibit...

CAS 478182-28-4 R-1479

R-1479
(CAS: 478182-28-4)

R1479 is a potent and highly specific inhibitor of HCV replication in cell culture, and that its triphosphate is a potent and highly selective inhibitor of NS5B...

CAS 394730-60-0 Boceprevir

Boceprevir
(CAS: 394730-60-0)

An NS3 serine protease inhibitor of hepatitis C virus, for the treatment of HCV infection.

CAS 690270-29-2 Balapiravir

Balapiravir
(CAS: 690270-29-2)

Balapiravir is the prodrug of a nucleoside analogue inhibitor of the hepatitis C virus (HCV) RNA-dependent RNA polymerase. It is the tri-isobutyrate ester prodr...

CAS 442666-98-0 Anguizole

Anguizole
(CAS: 442666-98-0)

Anguizole is a small molecule inhibitor of HCV replication and alters NS4B's subcellular distribution.

Vedroprevir
(CAS: 1098189-15-1)

Vedroprevir is a selective hepatitis C virus (HCV) NS3 protease inhibitor. It is a pharmaceutical drug that is used in the treatment of hepatitis C virus in pat...

CAS 1206524-86-8 MK-5172 potassium salt

MK-5172 potassium salt
(CAS: 1206524-86-8)

In biochemical assays, MK-5172 was effective against a panel of major genotypes and variants engineered with common resistant mutations observed in clinical stu...