(-)-Cotinine - CAS 486-56-6
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
(-)-Cotinine
Catalog Number:
486-56-6
Synonyms:
S-(-)-Cotinine; (5S)-1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone; (S)-(-)-1-Methyl-5-(3-pyridiyl)-2- pyrrolidinone;
CAS Number:
486-56-6
Description:
A carcinogen as a a major metabolite of Nicotine in humans.
Molecular Weight:
176.22
Molecular Formula:
C10H12N2O
Quantity:
Grams-Kilos
Quality Standard:
Enterprise Standard
COA:
Inquire
MSDS:
Inquire
Canonical SMILES:
CN1C(CCC1=O)C2=CN=CC=C2
InChI:
1S/C10H12N2O/c1-12-9(4-5-10(12)13)8-3-2-6-11-7-8/h2-3,6-7,9H,4-5H2,1H3/t9-/m0/s1
InChIKey:
UIKROCXWUNQSPJ-VIFPVBQESA-N
Targets:
Others
Chemical Structure
CAS 486-56-6 (-)-Cotinine

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Reference Reading


1.Nicotine dependence and urinary nicotine, cotinine and hydroxycotinine levels in daily smokers.
Van Overmeire I1, De Smedt T2, Dendale P3, Nackaerts K4, Vanacker H5, Vanoeteren J6, Van Laethem D7, Van Loco J2, De Cremer K2. Nicotine Tob Res. 2016 Apr 15. pii: ntw099. [Epub ahead of print]
INTRODUCTION: Nicotine dependence and smoking frequency are critical factors for smoking cessation. The aims of this study are 1) to determine if nicotine dependence FTND scores are associated with urinary levels of nicotine metabolites, 2) to assess the relationship of hydroxycotinine/cotinine ratio with FTND score and cigarettes smoked per day (CPD) and 3) to identify significant predictors of cigarettes per day among biomarker concentrations and individual FTND items.
2.Systematic Review and Meta-Analysis of the association between exposure to Environmental Tobacco Smoke and Periodontitis Endpoints among Non-Smokers.
Akinkugbe AA1, Slade GD2, Divaris K3, Poole C4. Nicotine Tob Res. 2016 Apr 15. pii: ntw105. [Epub ahead of print]
OBJECTIVE: We conducted a systematic review to summarize the epidemiological evidence on environmental tobacco smoke (ETS) exposure and prevalent periodontitis endpoints among non-smokers.
3.Is there a link between passive smoke exposure and early-onset myopia in preschool Asian children?
Chua SY1, Ikram MK2,3, Tan CS1, Stone RA4, Cai S5, Gluckman PD6,7, Yap SC5,6, Yap F8, Wong TY2,3,9, Ngo CS10, Saw SM1,2,3; GUSTO Study Group. Ophthalmic Physiol Opt. 2016 Apr 7. doi: 10.1111/opo.12285. [Epub ahead of print]
PURPOSE: To investigate the association of passive tobacco smoke exposure with early-onset myopia among three-year-old children in Singapore.
4.Smoking and Hand Dermatitis in the United States Adult Population.
Lai YC1, Yew YW2. Ann Dermatol. 2016 Apr;28(2):164-71. doi: 10.5021/ad.2016.28.2.164. Epub 2016 Mar 31.
BACKGROUND: Hand dermatitis is a common chronic relapsing skin disease resulting from a variety of causes, including endogenous predisposition and environmental exposures to irritants and allergens. Lifestyle factors such as smoking have been implicated in hand dermatitis.