(-)-Cotinine - CAS 486-56-6
Not Intended for Therapeutic Use. For research use only.
Product Name:
Catalog Number:
S-(-)-Cotinine; (5S)-1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone; (S)-(-)-1-Methyl-5-(3-pyridiyl)-2- pyrrolidinone;
CAS Number:
A carcinogen as a a major metabolite of Nicotine in humans.
Molecular Weight:
Molecular Formula:
Quality Standard:
Enterprise Standard
Canonical SMILES:
Chemical Structure
CAS 486-56-6 (-)-Cotinine

Related Products

(CAS: 1537859-24-7)

GNE-3500 has been found to be a Retinoic acid receptor-related Orphan receptor C agonist that could be probably significant in studies of some inflammatory dise...

(CAS: 1142090-23-0)

GSK2256294A, an effective inhibitor of human soluble epoxide hydrolase(sEH), was developed by GSK and still under Phase I trial in Chronic obstructive pulmonary...

CAS 300837-31-4 XCT 0315908

XCT 0315908
(CAS: 300837-31-4)

XCT 0315908, a RXR agonist, showed selectivity for RXR−Nurr1 over a broad range of other RXR dimerization partners but with rather low potency.

CAS 117570-53-3 DMXAA

(CAS: 117570-53-3)

STING agonist; Induces antitumor immunological responses

Epothilone F
(CAS: 208518-52-9)

Epothilone F, an active metabolite of Epothilone D, prevents cancer cells from dividing by interfering with tubulin.

Hybendazole hydrochloride
(CAS: 37975-24-9)

Hybendazole hydrochloride is a synthetic bio-active chemical.

CAS 470-17-7 Isoalantolactone

(CAS: 470-17-7)

Isoalantolactone has the capacity to inhibit tumor cell growth through induction of apoptosis.

CAS 138-14-7 Desferioxamine mesylate

Desferioxamine mesylate
(CAS: 138-14-7)

Deferoxamine mesylate, an iron chelator, could be used in the treatment of acute iron poisoning, sickle cell diseases and it is also found to have some extent o...

CAS 2646-71-1 NADPH tetrasodium salt

NADPH tetrasodium salt
(CAS: 2646-71-1)

NADPH tetrasodium salt is an ubiquitous coenzyme that acts as an electron donor in various biological reactions.

CAS 36861-47-9 4-Methylbenzylidene camphor

4-Methylbenzylidene camphor
(CAS: 36861-47-9)

4-Methylbenzylidene camphor (4-MBC) is an organic camphor derivative that is used in the cosmetic industry for its ability to protect the skin against UV, speci...

(CAS: 1137359-47-7)

BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression.

CBR 5884
(CAS: 681159-27-3)

CBR 5884 is a 3-Phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50 = 33 μM), does not affect other NAD+-dependent dehydrogenases.

CAS 155294-62-5 NB-598 Maleate

NB-598 Maleate
(CAS: 155294-62-5)

SE inhibitor NB-598 significantly inhibited both basal and glucose-stimulated insulin secretion from mouse pancreatic islets. CaV channels were markedly inhibit...

CAS 1477949-42-0 CAY10683

(CAS: 1477949-42-0)

Santacruzamate A (CAY10683) is a potent and selective HDAC inhibitor with IC50 of 119 pM for HDAC2, >3600-fold selectivity over other HDACs.

CAS 104795-66-6 CI-959 free acid

CI-959 free acid
(CAS: 104795-66-6)

CI-959 free acid is an orally effective inhibitor of cellular activation in both in vitro and animal models. It has antiallergic and anti-inflammatory propertie...

CAS 1218942-37-0 GKT137831

(CAS: 1218942-37-0)

GKT137831 attenuates hypoxia-induced H(2)O(2) release, cell proliferation, and TGF-β1 expression and blunted reductions in PPARγ in HPAECs and HPASMCs.

(CAS: 1531634-31-7)

AF38469 is a novel, selective, orally bioavailable Sortilin inhibitor and showed no inhibition or stimulation of >50% at 10μM in a standard selectivity panel of...

CAS 940-69-2 (+/-)-alpha-Lipoamide

(CAS: 940-69-2)

(+/-)-alpha-Lipoamide is a coenzyme, which transfer acetyl and hydrogen in Pyruvate deacylation oxidation process. It may be used in treatment of insulin resist...

(CAS: 1093861-60-9)

Afoxolaner is a potent isoxazoline insecticide and acaricide against Ixodes scapularis in dogs. It is indicated for the treatment and prevention of flea infesta...

CAS 36062-04-1 Tetrahydrocurcumin

(CAS: 36062-04-1)

Tetrahydrocurcumin is being studied for the treatment of cancer and dementia. It has antioxidant and anti-inflammatory properties. Tetrahydrocurcumin has been s...

Reference Reading

1.Nicotine dependence and urinary nicotine, cotinine and hydroxycotinine levels in daily smokers.
Van Overmeire I1, De Smedt T2, Dendale P3, Nackaerts K4, Vanacker H5, Vanoeteren J6, Van Laethem D7, Van Loco J2, De Cremer K2. Nicotine Tob Res. 2016 Apr 15. pii: ntw099. [Epub ahead of print]
INTRODUCTION: Nicotine dependence and smoking frequency are critical factors for smoking cessation. The aims of this study are 1) to determine if nicotine dependence FTND scores are associated with urinary levels of nicotine metabolites, 2) to assess the relationship of hydroxycotinine/cotinine ratio with FTND score and cigarettes smoked per day (CPD) and 3) to identify significant predictors of cigarettes per day among biomarker concentrations and individual FTND items.
2.Systematic Review and Meta-Analysis of the association between exposure to Environmental Tobacco Smoke and Periodontitis Endpoints among Non-Smokers.
Akinkugbe AA1, Slade GD2, Divaris K3, Poole C4. Nicotine Tob Res. 2016 Apr 15. pii: ntw105. [Epub ahead of print]
OBJECTIVE: We conducted a systematic review to summarize the epidemiological evidence on environmental tobacco smoke (ETS) exposure and prevalent periodontitis endpoints among non-smokers.
3.Is there a link between passive smoke exposure and early-onset myopia in preschool Asian children?
Chua SY1, Ikram MK2,3, Tan CS1, Stone RA4, Cai S5, Gluckman PD6,7, Yap SC5,6, Yap F8, Wong TY2,3,9, Ngo CS10, Saw SM1,2,3; GUSTO Study Group. Ophthalmic Physiol Opt. 2016 Apr 7. doi: 10.1111/opo.12285. [Epub ahead of print]
PURPOSE: To investigate the association of passive tobacco smoke exposure with early-onset myopia among three-year-old children in Singapore.
4.Smoking and Hand Dermatitis in the United States Adult Population.
Lai YC1, Yew YW2. Ann Dermatol. 2016 Apr;28(2):164-71. doi: 10.5021/ad.2016.28.2.164. Epub 2016 Mar 31.
BACKGROUND: Hand dermatitis is a common chronic relapsing skin disease resulting from a variety of causes, including endogenous predisposition and environmental exposures to irritants and allergens. Lifestyle factors such as smoking have been implicated in hand dermatitis.