Compound Screening Platform

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Disease models at molecular, cell and animal levels play critical roles in drug discovery. The biological activity of compounds sourced from chemical synthesis, natural products or biological molecules cannot be tested directly in the human body. The disease models which truthfully reflect the pathology of diseases serve effective and economical ways to explore the activity and corresponding mechanism of the compounds. Boc Sciences is applying more than 200 in vitro and in vivo bioassays of various disease models, including over 100 High-throughput screening (HTS) or high content screening (HCS) models, with the screening capacity reaching approximately 100,000 samples per day.

HTS is an innovative approach within the drug discovery paradigm that combines the application of multi-disciplinary knowledge with the integration of advanced technologies to expedite the identification and development of active molecules or "hits" into potential drug “leads” with desired therapeutic activity. Boc Sciences utilizes internationally validated HTS technologies, which have advantages such as the rapid detection of trace quantities with high sensitivity and accuracy. HTS decreases the amount of testing compound required such that only microgram quantities are needed, which permits certain natural products that are difficult to isolate and purify and for compounds that are difficult to synthesize to be assayed. Also compounds can be tested multiple times in different screening models, thereby increasing the probability of discovering new leads and drug candidates.

Boc Sciences also provide high content screening (HCS). HCS is based on automated high-resolution fluorescent microscopy imaging technology. It is a multi-parameter functional analysis system that can provide a large amount of biological information including cell growth, differentiation, migration, apoptosis, metabolic and signal transduction pathways. Insights from these information-rich analyses could help scientists to understand pharmacological and toxic properties of a lead compound at the early stage of discovery, thereby significantly improving the efficiency of candidate confirmation and resultant success rate of drug development.

Boc Sciences provides bioassays in:

  1. Cancers
  2. Cardiovascular diseases
  3. Neural system diseases
  4. Reproductive system diseases
  5. Respiratory system disease
  6. Metabolic diseases
  7. Infectious diseases

Based on these bioassays, Boc Sciences provides an efficient, economical and systematic one-stop screening platform to fulfill the clients’ need of drug discovery and development.

Anti-cancer drug screening assays
No. Assay Application Amount required Note
1 Leukemia cell line HL-60 Leukemia 2 mg; Mixture 15 mg Collect 10 samples
2 Lung adenocarcinoma cell line A549 Lung cancer 2 mg; Mixture 15 mg Collect 10 samples
3 Liver cancer cell line BEL-7402 Liver cancer 2 mg; Mixture 15 mg Collect 10 samples
4 Leukemia cell line K-562 Leukemia 2 mg; Mixture 15 mg At least 10 Samples
5 Leukemia cell line Molt-4 Leukemia 2 mg; Mixture 15 mg At least 10 Samples
6 Leukemia cell line Raji Leukemia 2 mg; Mixture 15 mg At least 10 Samples
7 Leukemia cell line U-937 Leukemia 2 mg; Mixture 15 mg At least 10 Samples
8 Colon cancer cell line HCT-116 Colon cancer 2 mg; Mixture 15 mg At least 10 Samples
9 Colon cancer cell line HCT-15 Colon cancer 2 mg; Mixture 15 mg At least 10 Samples
10 Colon cancer cell line HT-29 Colon cancer 2 mg; Mixture 15 mg At least 10 Samples
11 Colon cancer cell line LoVo Colon cancer 2 mg; Mixture 15 mg At least 10 Samples
12 Colon cancer cell line SW-1116 Colon cancer 2 mg; Mixture 15 mg At least 10 Samples
13 Colon cancer cell line WiDr Colon cancer 2 mg; Mixture 15 mg At least 10 Samples
14 Lung adenocarcinoma cell line NCI-H187 Lung cancer 2 mg; Mixture 15 mg At least 10 Samples
15 Lung adenocarcinoma cell line NCI-H23 Lung cancer 2 mg; Mixture 15 mg At least 10 Samples
16 Liver cancer cell line BEL-7404 Liver cancer 2 mg; Mixture 15 mg At least 10 Samples
17 Liver cancer cell line Hep3B Liver cancer 2 mg; Mixture 15 mg At least 10 Samples
18 Liver cancer cell line HepG2 Liver cancer 2 mg; Mixture 15 mg At least 10 Samples
19 Liver cancer cell line SMMC-7721 Liver cancer 2 mg; Mixture 15 mg At least 10 Samples
20 Cervical cancer cell line HeLa Cervical cancer 2 mg; Mixture 15 mg At least 10 Samples
21 Squamousline epithelium cancer cell  A-431 Epithelial cancer 2 mg; Mixture 15 mg At least 10 Samples
22 Squamousline epithelium cancer cell KB Epithelial cancer 2 mg; Mixture 15 mg At least 10 Samples
23 Ovarian cancer cell line 3AO Ovarian cancer 2 mg; Mixture 15 mg At least 10 Samples
24 Ovarian cancer cell line AO Ovarian cancer 2 mg; Mixture 15 mg At least 10 Samples
25 Ovarian cancer cell line HO-8910 Ovarian cancer 2 mg; Mixture 15 mg At least 10 Samples
26 Ovarian cancer cell line OVCAR-3 Ovarian cancer 2 mg; Mixture 15 mg At least 10 Samples
27 Ovarian cancer cell line SK-OV-3 Ovarian cancer 2 mg; Mixture 15 mg At least 10 Samples
28 Proliferation of endothelial cells Angiogenesis 2 mg; Mixture 15 mg At least 10 Samples
29 Prostate cancer cell line PC-3 Prostate cancer 2 mg; Mixture 15 mg At least 10 Samples
30 Breast cancer cell line MCF-7 Breast cancer 2 mg; Mixture 15 mg At least 10 Samples
31 Breast cancer cell line MDA-MB-231 Breast cancer 2 mg; Mixture 15 mg At least 10 Samples
32 Breast cancer cell line MDA-MB-435 Breast cancer 2 mg; Mixture 15 mg At least 10 Samples
33 Breast cancer cell line MDA-MB-468 Breast cancer 2 mg; Mixture 15 mg At least 10 Samples
34 Breast cancer cell line SK-BR-3 Breast cancer 2 mg; Mixture 15 mg At least 10 Samples
35 Stomach adenocarcinoma cell line AGS Stomach cancer 2 mg; Mixture 15 mg At least 10 Samples
36 Stomach adenocarcinoma cell line MKN-1 Stomach cancer 2 mg; Mixture 15 mg At least 10 Samples
37 Stomach adenocarcinoma cell line MKN-28 Stomach cancer 2 mg; Mixture 15 mg At least 10 Samples
38 Stomach adenocarcinoma cell line MKN-45 Stomach cancer 2 mg; Mixture 15 mg At least 10 Samples
39 Stomach adenocarcinoma cell line v Stomach cancer 2 mg; Mixture 15 mg At least 10 Samples
40 c-Kit tyrosine kinase 2 mg; Mixture 15 mg At least 10 Samples, Inquire
41 c-Src tyrosine kinase 2 mg; Mixture 15 mg At least 10 Samples, Inquire
42 Epidermal growth factor receptor (EGFR) tyrosine kinase tyrosine kinase 2 mg; Mixture 15 mg At least 10 Samples, Inquire
43 Vascular endothelialgrowth factor receptor 2 (VEGFR2) tyrosine kinase tyrosine kinase 2 mg; Mixture 15 mg At least 10 Samples, Inquire
44 In vitro colony formation Anti-cancer 2 mg; Mixture 15 mg Inquire
45 Tube formation Angiogenesis 2 mg; Mixture 15 mg Inquire
46 Migration of endothelial cells Angiogenesis 2 mg; Mixture 15 mg Inquire
47 Estrogen receptor competitive binding assay Breast cancer,osteoporosis 5-10 mg At least 8 Samples, Inquire
48 Glucocorticoid receptor competitive binding assay Nuclear receptor cross-reactivity 5-10 mg At least 8 Samples, Inquire
49 Androgen receptor competitive binding assay Prostate cancer,prostate enlargement 5-10 mg At least 8 Samples, Inquire
50 Mineralcorticoid receptor competitive binding assay Nuclear receptor cross-reactivity 5-10 mg At least 8 Samples, Inquire
51 Progesterone receptor competitive binding assay Breast cancer,uterine fibroids 5-10 mg At least 8 Samples, Inquire
52 Estrogen receptor agonist cellbased assay Breast cancer,osteoporosis 5-10 mg At least 8 Samples, Inquire
53 Estrogen receptor antagonist cell-based assay Breast cancer,osteoporosis 5-10 mg At least 8 Samples, Inquire
54 Androgen receptor agonist cell-based assay Prostate cancer,prostate enlargement 5-10 mg At least 8 Samples, Inquire
55 Androgen receptor antagonist cell-based assay Prostate cancer,prostate enlargement 5-10 mg At least 8 Samples, Inquire
56 Progesterone receptor agonist cell-based assay Breast cancer,uterine fibroids 5-10 mg At least 8 Samples, Inquire
57 Progesterone receptor antagonist cell-based assay Breast cancer,uterine fibroids 5-10 mg At least 8 Samples, Inquire
58 Urokinase Tumor 2 mg At least 3 Samples
59 Human methionine aminopeptidase type Ⅰ(HsMetAP1) Tumor angiogenesis 2 mg At least 10 Samples
60 20S proteosome assay Tumor 2 mg At least 3 Samples
61 Jnk Stimulatory Phosphatase-1 Tumor 2 mg At least 3 Samples
62 TC-PTP Cross-reactivity 2 mg At least 3 Samples
63 Protein tyrosine phosphatase G1 Cross-reactivity 2 mg At least 3 Samples
64 Protein tyrosine phosphatase α Tumor 2 mg At least 3 Samples
65 Protein tyrosine phosphatase ε Tumor, osteoporosis 2 mg At least 3 Samples
66 Protein tyrosine phosphatase PEST Cross-reactivity 2 mg At least 3 Samples
67 PTEN Tumor 2 mg At least 3 Samples
68 SHP2 Tumor 2 mg At least 3 Samples
69 Human MT1-MMP Cancer metastasis 2 mg At least 10 Samples
70 Human MT2-MMP Cancer metastasis 2 mg At least 10 Samples
71 Human MT3-MMP Cancer metastasis 2 mg At least 10 Samples
72 Human Gelatinase A Cancer metastasis 2 mg At least 10 Samples
73 Human Gelatinase B Cancer metastasis 2 mg At least 10 Samples
74 Human stromelysin 1 Cancer metastasis 2 mg At least 10 Samples
75 Human matrilysin Cancer metastasis 2 mg At least 10 Samples
76 Human collagenase 1 Cancer metastasis 2 mg At least 10 Samples
77 Human collagenase 3 Cancer metastasis 2 mg At least 10 Samples
78 Human Macrophage elastase (HME) Cancer metastasis 2 mg At least 10 Samples
79 VHR(DUSP3) Tumor 2 mg At least 3 Samples
80 GLEPP1 Nephritis 2 mg At least 3 Samples
81 SAP-1 Tumor 2 mg At least 3 Samples
82 Cdc25 A Anti-cancer 2 mg At least 3 Samples
83 Cdc25 B Anti-cancer 2 mg At least 3 Samples
84 PRL-3 Tumor 2 mg At least 3 Samples
85 HD-PTP Tumor 2 mg At least 3 Samples
86 Aurora A cancer 2 mg At least 3 Samples
87 JAK2 cancer 2 mg At least 3 Samples
88 JAK2 (JH1 JH2 domain V617F) cancer 2 mg At least 3 Samples
89 NFkB pathway inhibitor/activator Tumor 2 mg At least 3 Samples
90 AKT1 (PKB alpha) cancer 2 mg At least 3 Samples
91 LYN A cancer 2 mg At least 3 Samples
92 LYN B cancer 2 mg At least 3 Samples
93 RPS6KB1 (p70S6K) cancer 2 mg At least 3 Samples
94 Mitochondrion membrane potential Tumor 2 mg At least 3 Samples
95 CHEK2 (CHK2) cancer 2 mg At least 3 Samples
96 FRAP1 (mTOR) cancer 2 mg At least 3 Samples
97 FYN cancer 2 mg At least 3 Samples
98 JAK2 (JH1 JH2 domain) cancer 2 mg At least 3 Samples
99 AKT2 (PKB beta) cancer 2 mg At least 3 Samples
100 LCK cancer 2 mg At least 3 Samples
101 MAPK1 (Erk2) cancer 2 mg At least 3 Samples
102 MAPK3 (Erk1) cancer 2 mg At least 3 Samples
103 BRAF* cancer 2 mg At least 3 Samples
104 RAF1 (cRAF)* cancer 2 mg At least 3 Samples
105 Sirtuins (SIRT1) Cancer 2 mg At least 3 Samples
106 Histone deacetylase 1(HDAC1) Cancer 2 mg At least 3 Samples
107 Histone deacetylase 6(HDAC6) Cancer 2 mg At least 3 Samples
108 Histone deacetylase 8(HDAC8) Cancer 2 mg At least 3 Samples
109 Histone deacetylase 3(HDAC3) Cancer 2 mg At least 3 Samples
110 Histone deacetylase 10(HDAC10) Cancer 2 mg At least 3 Samples
111 Histone deacetylase 11(HDAC11) Cancer 2 mg At least 3 Samples
112 Histone deacetylase 2(HDAC2) Cancer 2 mg At least 3 Samples
113 Histone deacetylase 5(HDAC5) Cancer 2 mg At least 3 Samples
114 Histone deacetylase 9(HDAC9) Cancer 2 mg At least 3 Samples
115 MARK2 cancer 2 mg At least 3 Samples

Cardiovascular disease-related drug screening assays
1 Angiotensin converting enzyme (ACE) activity Hypertension 10compoundmg,Pure Collect 50 samples, Inquire
2 Contractile responses in isolated ventricular papillary muscle/atrium Heart failure 30compoundmg,Pure At least 10 Samples, Inquire
3 Contractile responses in isolated vascular smooth muscles Hypertension 30compoundmg,Pure At least 10 Samples, Inquire
4 Arrhythmia model in isolated guinea-pig atrium Arrhythmia 30compoundmg,Pure At least 10 Samples, Inquire
5 Thrombin Thrombosis 2 mg At least 3 Samples
6 α1A Adrenergic Receptor Calcium Assay - Agonist Hypertension,Heart Failure,Prostatic Hyperplasia 2 mg Collect 10 samples
7 α1A Adrenergic Receptor Calcium Assay - Antagonist Hypertension,Heart Failure,Prostatic Hyperplasia 2 mg Collect 10 samples
8 α1B Adrenergic Receptor Calcium Assay - Agonist Hypertension,Heart Failure,Prostatic Hyperplasia 2 mg Collect 10 samples
9 α1B Adrenergic Receptor Calcium Assay - Antagonist Hypertension,Heart Failure,Prostatic Hyperplasia 2 mg Collect 10 samples
10 α1D Adrenergic Receptor Calcium Assay - Agonist Hypertension,Heart Failure,Prostatic Hyperplasia 2 mg Collect 10 samples
11 α1D Adrenergic Receptor Calcium Assay - Antagonist Hypertension,Heart Failure,Prostatic Hyperplasia 2 mg Collect 10 samples
12 β1 Adrenergic Receptor Calcium Assay - Agonist Hypertension,Heart Failure 2 mg Collect 10 samples
13 β1 Adrenergic Receptor Calcium Assay - Antagonist Hypertension,Heart Failure 2 mg Collect 10 samples
14 Voltage-gated potassium channel hERG (manual patch clamp) Cardiac safty assess 2 mg At least 5 Samples
15 Voltage-gated potassium channel hERG (FDSS) Cardiac safty assess 2 mg At least 25 Samples
16 Voltage-gated potassium channel KCNQ1 (manual patch clamp) Cardiovascular system
disease
2 mg At least 5 Samples
17 Voltage-gated potassium channel Kir2.1 (manual patch clamp) Cardiovascular, muscle disease 2 mg At least 5 Samples

Immunomodulating drug screening assays
1 Type II collagen induced mouse Arthritis model Arthritis 2 mg Inquire
2 Detection of nitric oxide (NO) As above 2 mg At least 10 Samples, Inquire
3 NK cells activity As above 2 mg At least 10 Samples, Inquire
4 T/B lymphocyte proliferation Immunomodulation 2 mg Collect 10 samples, Inquire
5 Interferon-γ production As above 2 mg At least 10 Samples, Inquire
6 Interleukin-1 production As above 2 mg At least 10 Samples, Inquire
7 Interleukin-10 production As above 2 mg At least 10 Samples, Inquire
8 Interleukin-12 p40 production As above 2 mg At least 10 Samples, Inquire
9 Interleukin-2 production As above 2 mg At least 10 Samples, Inquire
10 Interleukin-4 production As above 2 mg At least 10 Samples, Inquire
11 Interleukin-5 production As above 2 mg At least 10 Samples, Inquire
12 Interleukin-6 production As above 2 mg At least 10 Samples, Inquire
13 Tumorproductionnecrosis factor-α As above 2 mg At least 10 Samples, Inquire
14 Interleukin-12 p70 production As above 2 mg At least 10 Samples, Inquire
15 Mixed lymphocyte reaction(MLR) Immunomodulation 2 mg At least 10 Samples, Inquire
16 Formyl peptide receptor agonist assay (cell-based) Inflammation 5-10 mg Collect 10 samples, Inquire
17 Formyl peptide receptor like-1 agonist assay (cell-based) Inflammation 5-10 mg Collect 8 samples, Inquire
18 CD45 Immunomodulation 2 mg At least 3 Samples
19 Caspase-1 Inflammation 2 mg At least 3 Samples
20 ZAP70 inflammation 2 mg At least 3 Samples
21 Syk Inflammation 2 mg At least 3 Samples
22 Chemokine Receptor CCR2 Calcium Assay - Agonist AIDS, Inflammatory Diseases, Autoimmune Diseases 2 mg Collect 10 samples
23 Chemokine Receptor CCR2 Calcium Assay - Antagonist AIDS, Inflammatory Diseases, Autoimmune Diseases 2 mg Collect 10 samples
24 Chemokine Receptor CCR5 GTPγS Binding Assay - Agonist AIDS, Multiple
Sclerosis, other immune
diseases
2 mg Collect 10 samples
25 Chemokine Receptor CCR5 GTPγS Binding Assay - Antagonist AIDS,Multiple
Sclerosis, other immune
diseases
2 mg Collect 10 samples
26 Chemokine Receptor CCR5 Calcium Assay - Agonist AIDS, Cancer, Inflammatory
Diseases, Autoimmune
Diseases
2 mg Collect 10 samples
27 Chemokine Receptor CCR5 Calcium Assay - Antagonist AIDS,Cancer,Inflammatory Diseases, Autoimmune
Diseases
2 mg Collect 10 samples
28 Chemokine Receptor CCR4 GTPgS Binding Assay - Agonist AIDS,tumor metastasis,other immune diseases 2 mg Collect 10 samples
29 Chemokine Receptor CCR4 GTPgS Binding Assay - Antagonist AIDS,tumor metastasis,other immune diseases 2 mg Collect 10 samples
30 Chemokine Receptor CXCR4 Calcium Assay - Agonist AIDS, Cancer, Inflammatory Diseases, Autoimmune Diseases 2 mg Collect 10 samples
31 Chemokine Receptor CXCR4 Calcium Assay - Antagonist AIDS, Cancer, Inflammatory Diseases, Autoimmune Diseases 2 mg Collect 10 samples
32 NFkB activation and translocation assay Signal transduction 2 mg Collect 10 samples, Inquire
33 STAT-1 activation and translocation assay Signal transduction 5-10 mg Inquire
34 ERK activation and translocation assay Signal transduction 2 mg Collect 10 samples, Inquire

Neural system drug screening assays
1 In vitro BuchE assay Hypermnesia 5 mg Collect 10 samples
2 In vitro AchE assay Hypermnesia 5 mg Collect 10 samples
3 6-OHDA induced PC12 cell injury Neural protection 5 mg Collect 10 samples
4 Glutamate-induced PC12 cell injury Neural protection 5 mg Collect 10 samples
5 H2O2-induced PC12 cell injury Neural protection 5 mg Collect 10 samples
6 Corticosterone-induced PC12 cell injury Depression 5 mg Collect 10 samples
7 OGD-induced PC12 cell injury Cerebral ischemia 5 mg Collect 10 samples
8 NMDA induced PC12 cell injury Depression 5 mg Collect 10 samples
9 β-amyloid-induced PC12 cell injury Neural protection 5 mg Collect 10 samples
10 H2O2-induced SH-SY5Y cell injury Neural protection 5 mg Collect 10 samples
11 β-amyloid-induced SH-SY5Y cell injury Neural protection 5 mg Collect 10 samples
12 OGD-induced SH-SY5Y cell injury Neural protection 5 mg Collect 10 samples
13 6-OHDA induced SH-SY5Y cell injury Neural protection 5 mg Collect 10 samples
14 Corticosterone-induced SH-SY5Y cell injury Neural protection 5 mg Collect 10 samples
15 Rotenone-induced PC12 cell injury Neural protection 5 mg Collect 10 samples
16 Rotenone-induced SH-SY5Y cell injury Neural protection 5 mg Collect 10 samples
17 Okadaic acid-induced PC12 cell injury Neural protection 5 mg Collect 10 samples
18 Okadaic acid-induced SH-SY5Y cell injury Neural protection 5 mg Collect 10 samples
19 Sodium azide-induced PC12 cell injury Neural protection 5 mg Collect 10 samples
20 Sodium azide-induced SH-SY5Y cell injury Neural protection 5 mg Collect 10 samples
21 Electroshock-induced seizures in mice Epilepsy 20-30 mg
22 Open field test Stress 20-30 mg
23 Climbing up test Muscle relaxation 20-30 mg
24 Acetic acid-induced writhing Analgesia 20-30 mg
25 Spontaneous activities Sedative 20-30 mg
26 NaNO2-induced hypoxic Cerebral ischemia 20-30 mg
27 Xylene-induced swelling Inflammation 50 mg
28 The tail suspension test Depression 20-30 mg
29 The forced swim test Depression 20-30 mg
30 Mouse water maze test Noesis amelioration 200 mg Inquire
31 Neurotransmitter detection CNS diseases 1 g Inquire
32 Enzyme kinetics Enzyme inhibition 20 mg Inquire
33 Cerebral injury caused by MCAO Cerebral ischemia 0.5-1 g Inquire
34 β-secretase assay β-secretase inhibition 5 mg At least 4 Samples
35 Rat water maze test Noesis amelioration 0.5-1 g Inquire
36 Caspase-2 Cross-reactivity 2 mg At least 3 Samples
37 Caspase-3 Alzheimer's Disease,cerebral ischemia 2 mg At least 3 Samples
38 Caspase-6 Cross-reactivity 2 mg At least 3 Samples
39 Caspase-7 Cross-reactivity 2 mg At least 3 Samples
40 Caspase-8 Cross-reactivity 2 mg At least 3 Samples
41 Caspase-9 Cross-reactivity 2 mg At least 3 Samples
42 Protein tyrosine phosphatase σ Cross-reactivity 2 mg At least 3 Samples
43 GSK3β Diabetes, AD 2 mg At least 3 Samples
44 CDK5/p25 Neurodegenerative diseases 2 mg At least 3 Samples
45 Autophagy Neurodegenerative diseases 2 mg At least 3 Samples
46 β-Secretase 1 Alzheimer's Disease 2 mg At least 3 Samples
47 Delta-Opioid Receptor (DOR) Calcium Assay - Agonist Delta-Opioid Receptor (DOR) Pain, Drug Tolerance and Dependence,Inflammatory Diseases 2 mg Collect 10 samples
48 Delta-Opioid Receptor (DOR) Calcium Assay - Antagonist Pain, Drug Tolerance and Dependence,Inflammatory Diseases 2 mg Collect 10 samples
49 Kappa-Opioid Receptor (KOR) Calcium Assay - Agonist Pain, Drug Tolerance and Dependence 2 mg Collect 10 samples
50 Kappa-Opioid Receptor (KOR) Calcium Assay - Antagonist Pain, Drug Tolerance and Dependence 2 mg Collect 10 samples
51 Mu-Opioid Receptor (MOR) Calcium Assay - Agonist Pain, Drug Tolerance and Dependence 2 mg Collect 10 samples
52 Mu-Opioid Receptor (MOR) Calcium Assay - Antagonist Pain, Drug Tolerance and Dependence 2 mg Collect 10 samples
53 Serotonin Receptor 5HT4R cAMP Assay - Agonist Cognitive deficits, Abdominal pain and Feeding disorders 2 mg Collect 10 samples
54 Serotonin Receptor 5HT4R cAMP Assay - Antagonist Cognitive deficits, Abdominal pain and Feeding disorders 2 mg Collect 10 samples
55 Cannabinoid Receptor CB2 Calcium Assay - Agonist Pain,Drug Addiction,Autoimmune Diseases 2 mg Collect 10 samples
56 Cannabinoid Receptor CB2 Calcium Assay - Antagonist Pain,Drug Addiction,Autoimmune Diseases 2 mg Collect 10 samples
57 Dopamine Receptor 1 (DRD1) Calcium Assay - Agonist Depression, Schizophrenia,Parkinson's Disease 2 mg Collect 10 samples
58 Dopamine Receptor 1 (DRD1) Calcium Assay - Antagonsit Depression, Schizophrenia,Parkinson's Disease 2 mg Collect 10 samples
59 Dopamine Receptor 2 (DRD2) Calcium Assay - Agonist Depression, Schizophrenia,Parkinson's Disease 2 mg Collect 10 samples
60 Dopamine Receptor 2 (DRD2) Calcium Assay - Antagonsit Depression, Schizophrenia,Parkinson's Disease 2 mg Collect 10 samples
61 Dopamine Receptor 5 (DRD5) Calcium Assay - Agonist Depression, Schizophrenia,Parkinson's Disease 2 mg Collect 10 samples
62 Dopamine Receptor 5 (DRD5) Calcium Assay - Antagonsit Depression, Schizophrenia,Parkinson's Disease 2 mg Collect 10 samples
63 MAO activity assay Parkinson's Disease,depression >5 mg Collect 10 samples, Inquire
64 NO production inhibition test Neural protection >5 mg Collect 10 samples, Inquire
65 Mouse hot-plate test Pain 20 mg Collect 10 samples, Inquire
66 The mouse taiL pressure test Pain 20 mg Collect 10 samples, Inquire
67 Anti inflammatory experiment (Carrageenan induced paw of mouse edema model) Inflammation 20 mg Collect 10 samples, Inquire
68 Voltage-gated potassium channel KCNQ2 (manual patch clamp) CNS disease 2 mg At least 5 Samples
69 Voltage-gated potassium channel KCNQ3 (manual patch clamp) CNS disease 2 mg At least 5 Samples
70 Voltage-gatedpotassium channel KCNQ4 (manual patch clamp) Deaf 2 mg At least 5 Samples
71 Voltage-gatedpotassium channel KCNQ2 (FDSS) Epilepsy, pain 2 mg At least 25 Samples
72 Nonselective cation channel TRPA1(manual patch clamp) Pain 2 mg At least 5 Samples
73 Nonselective cation channel TRPA1(FDSS) Pain 2 mg At least 25 Samples
74 Voltage-gated potassium channel Kv1.1(manual patch clamp) Multiple sclerosis 2 mg At least 5 Samples
75 Voltage-gated potassium channel Kv1.2(manual patch clamp) Multiple sclerosis 2 mg At least 5 Samples
76 MES,PTZ Epilepsy 50mg At least 5 Samples

Reproductive health-related drug screening assays
1 Estrogen activity assay Gynecological diseases 1-2 g At least 5 Samples, Inquire
2 Spermicidal test (in vitro) Planned parenthood 5 mg At least 5 Samples, Inquire
3 Anti-estrogen activity test Gynecological diseases 1-2 g At least 5 Samples, Inquire
4 Anti-ovulation test Planned parenthood 2 g At least 5 Samples, Inquire
5 Antiandrogen activity test Urological diseases 1-2 g At least 5 Samples, Inquire
6 Anti-progesterone activity test Planned parenthood 1-2 g At least 5 Samples, Inquire
7 Terminating early pregnancy Early pregnancy termination 2 g At least 5 Samples, Inquire
8 Anti-implantation test Early pregnancy termination 2 g At least 5 Samples, Inquire
9 Sexual behavior test (mounting) Urological diseases 2 g At least 5 Samples, Inquire
10 Human decidual cell growth
inhibition assay
Early pregnancy termination 5 mg At least 5 Samples, Inquire
11 Mouse model for Prostatic
Hyperplasia
Prostatic Hyperplasia 2 g Inquire
12 Androgen activity assay Urological diseases 1-2 g At least 5 Samples, Inquire
13 Male anti-fertility test Planned parenthood 2 g At least 5 Samples, Inquire
14 Progesterone activity assay Gynecological diseases 1-2 g At least 5 Samples, Inquire
15 Experimental model for
endometriosis(rats or rabbits)
Gynecological diseases 2 g Inquire

Respiratory disease-related drug screening assays
1 β2 Adrenergic Receptor Calcium Assay - Agonist Asthma,Bronchospasm,COPD 2 mg Collect 10 samples
2 β2 Adrenergic Receptor Calcium Assay - Antagonist Asthma,Bronchospasm,COPD 2 mg Collect 10 samples

Metabolic disease-related drug screening assays
1 Glucagon receptor cell-based assay Metabolic diseases 5-10 mg Collect 8 samples, Inquire
2 Glucagon-like peptide-1 receptor cell-based assay Diabetes, obesity 5-10 mg At least 8 Samples, Inquire
3 Leucocyte common antigen related protein Diabetes, obesity 2 mg At least 3 Samples
4 Protein tyrosine phosphatase (PTP1B) Diabetes, obesity 2 mg At least 3 Samples
5 PEPCK transcriptional level expression assay Diabetes 2 mg At least 3 Samples
6 Triglyceride content assay Diabetes 2 mg At least 3 Samples
7 IKKβ Diabetes,CAD 2 mg At least 3 Samples
8 PLK2 Diabetes 2 mg At least 3 Samples
9 PLK3 Diabetes 2 mg At least 3 Samples
10 PKCθ Diabetes 2 mg At least 3 Samples
11 Endoplasmic reticulum (ER) stress-C/EBP homologues protein (CHOP) pathway inhibitor/activator Diabetes and tumor 2 mg At least 3 Samples
12 Endoplasmic reticulum (ER) stress- GRP78 pathway inhibitor/activator Diabetes and tumor 2 mg At least 3 Samples
13 Phosphorylation of Insulin receptor on CHO/Hir Diabetes 2 mg At least 3 Samples
14 PLK1 Diabetes 2 mg At least 3 Samples
15 DPP IV Diabetes 2 mg At least 3 Samples
16 DPP7 Diabetes 2 mg At least 3 Samples
17 DPP8 Diabetes 2 mg At least 3 Samples
18 DPP9 Diabetes 2 mg At least 3 Samples
19 Phosphorylation of AMPK and ACC on L6 myotubes Diabetes 2 mg At least 3 Samples
20 GLUT4 translocation assay of 3T3 -L1 cell lines Diabetes 2 mg At least 3 Samples
21 Adipogenesis assay of 3T3-L1 Diabetes 2 mg At least 3 Samples
22 AMPK a1, b1, g1 Diabetes 2 mg At least 3 Samples
23 AMPKa2b1g1 Diabetes 2 mg At least 3 Samples
24 Glucose uptake of L6 Diabetes 2 mg At least 3 Samples
25 PDK1* Diabetes 2 mg At least 3 Samples
26 Anti-insulin resistance (insulin induced) Diabetes 2 mg At least 3 Samples
27 Glucose uptake of 3T3-L1 Diabetes 5 mg Collect 5 samples
28 Insulin secretion assay of HITT15 Diabetes 5 mg At least 5 Samples, Inquire
29 Chemical induced Diabetic mouse model Diabetes 1-2 g Inquire
30 Glucosidase inhibition in vivo assay Diabetes 1-2 g Inquire
31 Animal Diabetes model for type 2 genetic Diabetes 1-2 g Inquire
32 Anti-osteoporosis assay Osteoporosis 50-80 mg Inquire
33 Cannabinoid Receptor CB1 Calcium Assay - Agonist Obesity, Drug Dependence, Substance Abuse, Memory Disorders, GI Track Disorders, Cardiovascular Diseases, Cancer  2 mg Collect 10 samples
34 Cannabinoid Receptor CB1 Calcium Assay - Antagonist Obesity, Drug Dependence,Substance Abuse, Memory Disorders, GI Track Disorders, Cardiovascular Diseases, Cancer 2 mg Collect 10 samples
35 Cannabinoid Receptor CB1 Receptor Binding Assay Obesity, Pain,Drug Addiction 2 mg Collect 10 samples
36 Cannabinoid Receptor CB2 Receptor Binding Assay Inflammation, Osteoporosis,Pain 2 mg Collect 10 samples
37 Melanocortin Receptor 3 (MC3) Luciferase Assay - Agonist Obesity, feeding disorder,sexual disfunction 2 mg Collect 10 samples
38 Melanocortin Receptor 3 (MC3) Luciferase Assay - Antagonist Obesity, feeding disorder,sexual disfunction 2 mg Collect 10 samples
39 Melanocortin Receptor 4 (MC4) Luciferase Assay - Agonist Obesity, feeding disorder,sexual disfunction 2 mg Collect 10 samples
40 Melanocortin Receptor 4 (MC4) Luciferase Assay - Antagonist Obesity, feeding disorder,sexual disfunction 2 mg Collect 10 samples
41 β3 Adrenergic Receptor Calcium Assay - Agonist Obesity 2 mg Collect 10 samples
42 β3 Adrenergic Receptor Calcium Assay - Antagonist Obesity 2 mg Collect 10 samples
43 Glucagon Receptor(GCGR)Calcium Assay - Agonist Diabetes 2 mg Collect 10 samples
44 Glucagon Receptor(GCGR)Calcium Assay - Antagonist Diabetes 2 mg Collect 10 samples
45 Glucagon Like Peptide-1 Receptor (GLP-1R)Calcium Assay - Agonist Diabetes 2 mg Collect 10 samples
46 Glucagon Like Peptide-1 Receptor(GLP-1R)Calcium Assay -Antagonist Diabetes 2 mg Collect 10 samples
47 Glucagon Like Peptide-1 Receptor (GLP-1R)Calcium Assay -Antagonist Metabolic diseases 5-10 mg Collect 10 samples
48 Neuromedin U Receptor 1 antagonist assay (cell-based) Metabolic diseases 5-10 mg Collect 10 samples
49 GPR119 agonist assay (cellbased) Metabolic diseases 5-10 mg Collect 10 samples
50 Voltage-gated potassium channel Kv2.1(manual patch clamp) Diabetes 2 mg At least 5 Samples

Anti-infection drug screening assays
1 Staphylococcus aureus Anti-bacterium 2mg Collect 10 samples
2 Staphylococcus epidermidis Anti-bacterium 2mg Collect 10 samples
3 Micrococcus lutens Anti-bacterium 2mg Collect 10 samples
4 Escherichia coli Anti-bacterium 2mg Collect 10 samples
5 Shigella Anti-bacterium 2mg Collect 10 samples
6 Pseudomonas aeruginosa Anti-bacterium 2mg Collect 10 samples
7 Candida albicans Anti-fungus 2mg Collect 10 samples
8 Streptococcus mutans Anti-anaerobic bacterium 2mg Collect 10 samples
9 Aspergillus niger Anti-fungus 2mg Collect 10 samples
10 Trichophyton rubrum Anti-fungus 2mg Collect 10 samples
11 Pityrosporum sabour Anti-fungus 2mg Collect 10 samples
12 Sake yeast Anti-fungus 2mg Collect 10 samples
13 Trichophyton mentagrophytes Anti-fungus 2mg Collect 10 samples
14 Cryptococcus neoformans Anti-fungus 2-6 mg Collect 10 samples
15 Candida parapsilosis Anti-fungus 2-6 mg Collect 10 samples
16 Candida glabrata Anti-fungus 2-6 mg Collect 10 samples
17 Candida tropicalis Anti-fungus 2-6 mg Collect 10 samples
18 Microsporum gypseum Anti-fungus 2-6 mg Collect 10 samples
19 Aspergillus fumigatus Anti-fungus 2-6 mg Collect 10 samples
20 Influenza A virus (MDCK) Anti-virus 5 mg Collect 5 samples
21 Influenza B virus (MDCK) Anti-virus 5 mg Collect 5 samples
22 Herpes simplex virus type 1 (Vero)  Anti-virus 5 mg Collect 5 samples
23 Herpes simplex virus type 2 (Vero) Anti-virus 5 mg Collect 5 samples
24 Coxsackie B3 virus(Vero) Anti-virus 5 mg Collect 5 samples
25 Coxsackie B6 virus(Vero) Anti-virus 5 mg Collect 5 samples
26 Human immunodeficiency virus-1 protease Anti-virus 5 mg Collect 10 samples
27 Human immunodeficiency virus-1 reverse transcriptase Anti-virus 5 mg Collect 10 samples
28 Human immunodeficiency virus-1 integrase Anti-virus 5 mg Collect 10 samples
29 Duck hepatitis B virus replication complexes DNA polymerase Anti-virus 5 mg Collect 10 samples, Inquire
30 Hepatitis B virus (HBsAg, HBeAg,DNA) Anti-virus 10 mg At least 5 Samples, Inquire
31 the evaluation of dengue virus therapeutic agents dengue virus 5-10 mg Inquire
32 the evaluation of HCV therapeutic agents HCV 5-10 mg Inquire
33 the evaluation of Flu virus therapeutic agents Flu virus 5-10 mg Inquire
34 HIV-1 IIIB Anti-virus 20 mg Inquire
35 Respiratory syncytial virus (Hep-2) Anti-virus 8 mg Collect 5 samples, Inquire
36 Adenovirus-3 Anti-virus 8 mg Collect 5 samples, Inquire
37 Adenovirus-7 Anti-virus 8 mg Collect 5 samples, Inquire
38 Human cytomegalovirus (Hel) Anti-virus 8 mg Collect 5 samples, Inquire
39 Vesicular stomatitis virus (Vero)    Anti-virus 8 mg Collect 5 samples, Inquire
40 HCV protease Anti-virus 5 mg Collect 10 samples, Inquire
41 Helicobatter pylori Peptic ulcer 2-3 mg Collect 10 samples
42 Methionine Aminopeptidase from E. coli (EcMetAP1)  Anti-bacterium 2 mg At least 10 Samples
43 Methionine Aminopeptidase typeⅠfrom S. cerevisin (ScMetAP1) Anti-fungus 2 mg At least 10 Samples
44 SARS 3C-like proteinase Anti-Sars 2 mg At least 3 Samples
45 SHP1 Infections disease 2 mg At least 3 Samples

Others
1 Caspase-10 Cross-reactivity 2 mg At least 3 Samples
2 Caspase-4 Cross-reactivity 2 mg At least 3 Samples
3 MMP26 Cross-reactivity 2 mg At least 3 Samples
4 DUSP13 Cross-reactivity 2 mg At least 3 Samples
5 Human cytochrome P450/CYP1A2 assay pharmacokinetics 2 mg At least 3 Samples
6 Human cytochrome P450/CYP2C19 assay pharmacokinetics 2 mg At least 3 Samples
7 Human cytochrome P450/CYP2C9 assay pharmacokinetics 2 mg At least 3 Samples
8 Human cytochrome P450/CYP2D6 assay pharmacokinetics 2 mg At least 3 Samples
9 Human cytochrome P450/CYP3A4 assay pharmacokinetics 2 mg At least 3 Samples
10 IKBKB (IKK beta) 2 mg At least 3 Samples
11 PKA 2 mg At least 3 Samples
12 JAK3 2 mg At least 3 Samples
13 AKT3 (PKB gamma) Cross-reactivity 2 mg At least 3 Samples
14 PKC alpha 2 mg At least 3 Samples
15 PKC beta I 2 mg At least 3 Samples
16 PKC beta II 2 mg At least 3 Samples
17 PKC delta 2 mg At least 3 Samples
18 PKC epsilon 2 mg At least 3 Samples
19 PKC eta 2 mg At least 3 Samples
20 PKC gamma 2 mg At least 3 Samples
21 PKC iota 2 mg At least 3 Samples
22 PKC zeta 2 mg At least 3 Samples
23 PRKD1 (PKD, PKC mu) 2 mg At least 3 Samples
24 PRKD2 (PKD2) 2 mg At least 3 Samples
25 PRKCN (PKD3) 2 mg At least 3 Samples
26 CaMKII alpha 2 mg At least 3 Samples
27 CaMKII beta 2 mg At least 3 Samples
28 CaMKII delta 2 mg At least 3 Samples
29 CaMKK beta 2 mg At least 3 Samples
30 RPS6KA1 (RSK1) 2 mg At least 3 Samples
31 RPS6KA2 (RSK3) 2 mg At least 3 Samples
32 RPS6KA3 (RSK2) 2 mg At least 3 Samples
33 RPS6KA5 (MSK1) 2 mg At least 3 Samples
34 RPS6KA6 (RSK4) 2 mg At least 3 Samples
35 PRKG2 (PKG2) 2 mg At least 3 Samples
36 PRKG1 (PKG1) 2 mg At least 3 Samples
37 MAPK12 (p38 gamma) 2 mg At least 3 Samples
38 GSK3 alpha Cross-reactivity 2 mg At least 3 Samples
39 CDK1/cyclin B 2 mg At least 3 Samples
40 CDK5/p35 2 mg At least 3 Samples
41 BRSK1 2 mg At least 3 Samples
42 CHEK1 (CHK1) 2 mg At least 3 Samples
43 JAK1 2 mg At least 3 Samples
44 beta-secretase 2 Cross-reactivity 2 mg At least 3 Samples
45 LTK 2 mg At least 3 Samples
46 FAP Cross-reactivity 2 mg At least 3 Samples
47 PTK2B (FAK2) 2 mg At least 3 Samples
48 CaMKI delta 2 mg At least 3 Samples
49 MAPK10 (JNK3)* 2 mg At least 3 Samples
50 MAPK13 (p38 delta) 2 mg At least 3 Samples
51 MAPK14 (p38 alpha)* 2 mg At least 3 Samples
52 MAPK8 (JNK1)* 2 mg At least 3 Samples
53 MAPK9 (JNK2)* 2 mg At least 3 Samples
54 CDK2/cyclin A 2 mg At least 3 Samples
55 Aurora C Cross-reactivity 2 mg At least 3 Samples
56 RPS6KA4 (MSK2) 2 mg At least 3 Samples
57 MAPK11 (p38 beta) 2 mg At least 3 Samples
58 MAP2K1 (MEK1)* 2 mg At least 3 Samples
59 MAP2K2 (MEK2)* 2 mg At least 3 Samples
60 MAP2K6 (MKK6)* 2 mg At least 3 Samples
61 MARK1 2 mg At least 3 Samples
62 Aurora B Cross-reactivity 2 mg At least 3 Samples
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