(+)-Cloprostenol isopropyl ester - CAS 157283-66-4
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
(+)-Cloprostenol isopropyl ester
Catalog Number:
157283-66-4
Synonyms:
(+)-Cloprostenol isopropyl ester; HE113833; LP014937; (5Z)-7-[(1R,2R,3R,5S)-2-[(1E,3R)-4-(3-Chlorophenoxy)-3-hydroxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl]-5-heptenoic Acid 1-Methylethyl Ester; [1R-[1α(Z),2β(1E,3R*),3α,5α]]-7-[2-[4-(3-Chlorophenoxy)-3-hy
CAS Number:
157283-66-4
Description:
(+)-Cloprostenol isopropyl ester is a derivative of cloprostenol which has been found to be a FP receptor agonist as well as a luteolytic agent and could be used commonly as a veterinary drug for its effect in terminating pregnancy.
Molecular Weight:
466.99
Molecular Formula:
C25H35ClO6
Quantity:
Milligram-Grams
Quality Standard:
In-house standard
COA:
Inquire
MSDS:
Inquire
Canonical SMILES:
CC(C)OC(=O)CCCC=CCC1C(CC(C1C=CC(COC2=CC(=CC=C2)Cl)O)O)O
InChI:
InChI=1S/C25H35ClO6/c1-17(2)32-25(30)11-6-4-3-5-10-21-22(24(29)15-23(21)28)13-12-19(27)16-31-20-9-7-8-18(26)14-20/h3,5,7-9,12-14,17,19,21-24,27-29H,4,6,10-11,15-16H2,1-2H3
InChIKey:
OCNSAYQJDKJOLH-UHFFFAOYSA-N
Targets:
Others
Chemical Structure
CAS 157283-66-4 (+)-Cloprostenol isopropyl ester

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Reference Reading


1.Agonist activity of bimatoprost, travoprost, latanoprost, unoprostone isopropyl ester and other prostaglandin analogs at the cloned human ciliary body FP prostaglandin receptor.
Sharif NA1, Kelly CR, Crider JY. J Ocul Pharmacol Ther. 2002 Aug;18(4):313-24.
We have determined the agonist activity of a number of natural prostaglandins and prostaglandin analogs at the FP prostaglandin receptor cloned from a human ciliary body cDNA library using phosphoinositide (PI) turnover assays. Travoprost acid (EC50 = 3.2 +/- 0.6 nM) was the most potent agonist in these cells followed by bimatoprost free acid (17-phenyl-trinor PGF2alpha; EC50 = 5.8 +/- 2.6 nM), fluprostenol (EC50 = 6.1 +/- 1.5 nM), and latanoprost free acid (PHXA85; EC50 = 54.6 +/- 12.4 nM) which was 17-fold weaker (p < 0.001) than travoprost acid. Unoprostone and S-1033 were significantly (p < 0.001) weaker than travoprost acid. The amide prodrug, bimatoprost (EC50 = 694 +/- 293 nM), activated this FP receptor with an intermediate potency. The isopropyl ester prodrugs, travoprost (EC50 = 42.3 +/- 6.7 nM), latanoprost (EC50 = 126 +/- 347 nM) and unoprostone isopropyl ester (EC50 = 9,100 +/- 2,870 nM), also exhibited FP agonist activity.