(+)-Cloprostenol - CAS 54276-21-0
Main Product
Product Name:
Catalog Number:
(+)-9ALPHA,11ALPHA,15-TRIHYDROXY-16-(3-CHLOROPHENOXY)-17,18,19,20-TETRANOR-PROSTA-5Z,13E-DIEN-1-OIC ACID; (+)-16-M-CHLOROPHENOXY TETRANOR PROSTAGLANDIN F2ALPHA; Superphan; (5Z)-7-[(1R,2R,3R,5S)-2-[(1E,3R)-4-(3-Chlorophenoxy)-3-hydroxy-1-buten-1-yl]-3,5-dihy
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Chemical Structure
CAS 54276-21-0 (+)-Cloprostenol

Reference Reading

1.The effect of puerperal uterine disease on histopathologic findings and mRNA expression of proinflammatory cytokines of the endometrium in dairy cows.
Heppelmann M1, Weinert M2, Ulbrich SE3, Brömmling A2, Piechotta M2, Merbach S4, Schoon HA5, Hoedemaker M2, Bollwein H6. Theriogenology. 2016 Apr 15;85(7):1348-56. doi: 10.1016/j.theriogenology.2015.12.022. Epub 2015 Dec 30.
The aim of this study was to investigate the effect of puerperal uterine disease on histopathologic findings and gene expression of proinflammatory cytokines in the endometrium of postpuerperal dairy cows; 49 lactating Holstein-Friesian cows were divided into two groups, one without (UD-; n = 29) and one with uterine disease (UD+; n = 21), defined as retained fetal membranes and/or clinical metritis. General clinical examination, vaginoscopy, transrectal palpation, and transrectal B-mode sonography were conducted on days 8, 11, 18, and 25 and then every 10 days until Day 65 (Day 0 = day of calving). The first endometrial sampling (ES1; swab and biopsy) was done during estrus around Day 42 and the second endometrial sampling (ES2) during the estrus after synchronization (cloprostenol between days 55 and 60 and GnRH 2 days later). The prevalence of histopathologic evidence of endometritis, according to the categories used here, and positive bacteriologic cultures was not affected by group (P > 0.
2.Improved fertility in suckled beef cows ovulating large follicles or supplemented with long-acting progesterone after timed-AI.
Pugliesi G1, Santos FB2, Lopes E2, Nogueira É3, Maio JR4, Binelli M2. Theriogenology. 2016 Apr 15;85(7):1239-48. doi: 10.1016/j.theriogenology.2015.12.006. Epub 2015 Dec 18.
We aimed to evaluate the effects and the interaction of size of the preovulatory follicle (POF) and long-acting progesterone (P4) supplementation after timed-AI on CL function and pregnancy success in beef cows. In experiment 1, ovulations of beef cows were synchronized starting on Day -10, and cows were split to receive sodium cloprostenol (large follicle group; LF; n = 31) or nothing (small follicle group; SF; n = 35). Ovulations were induced on Day 0, and cows were inseminated. Ovulated cows were assigned to receive placebo (LF/control group, n = 14; and SF/control group, n = 9) or 150 mg of long-acting P4 on Day 4.5 (LF/P4 group, n = 13; and SF/P4 group, n = 12). Diameter of POF, blood flow in POF wall, ovulation rate, and size and vascularization of CL were greater (P < 0.05) in LF group. In experiments 2 (unknown cyclic status) and 4 (noncycling), ovulations were synchronized, and beef cows received placebo or 150 mg of long-acting P4 on Day 4 after timed-artificial insemination.
3.Effect of the combination of male effect with PGF2α on estrus synchronization of hair sheep in Mexican tropic.
Alavez-Ramírez A1, Montes-Pérez R1, Aguilar-Caballero AJ2, Ortega-Pacheco A1. Trop Anim Health Prod. 2016 Mar;48(3):655-8. doi: 10.1007/s11250-015-0977-2. Epub 2015 Dec 23.
The aim of this study was to evaluate the "male effect" at the end of protocol with prostaglandins (PG) on estrus synchronization of hair sheep during breeding season (November-December) in Yucatan, Mexico. Twenty female Pelibuey sheep (weighting 38.2 ± 1.6 kg and body condition score of 2.5 ± 0.5) were randomly distributed in two groups (n = 10). Group T1 (control, PG), two doses of 50 μg of cloprostenol with 12 days between applications were applied; in the second group T2 (PG-ME), ewes received the same PG protocol plus the introduction of a male at the end of treatment. The interval of end treatment-onset of estrus was analyzed using survival test; the number of sheep with presence/absence of estrus was analyzed using Fisher's exact test. Ewes in estrus for groups T1 and T2 were 5 vs. 8, respectively. No significant differences were found as regards the interval end of treatment-onset of estrus (P > 0.05), as well as in total proportion of ewes with estrus and likewise in the duration of it (P > 0.
4.Efficiency of different hormonal treatments for estrus synchronization in tropical Santa Inês sheep.
Texeira TA1, da Fonseca JF2, de Souza-Fabjan JM1, de Rezende Carvalheira L1, de Moura Fernandes DA1, Brandão FZ3. Trop Anim Health Prod. 2016 Mar;48(3):545-51. doi: 10.1007/s11250-015-0989-y. Epub 2016 Jan 6.
The aim of this study was to evaluate the effect of (i) the duration of hormone treatment with progestogen sponges during the seasonal anestrus and (ii) the administration of two doses of prostaglandin at 7 days apart during the breeding season on reproductive parameters of Santa Inês ewes. In experiment 1, 32 ewes received intravaginal MAP sponges for 6 (G6 days), 9 (G9 days), or 12 (G12days) days and 75 μg D-cloprostenol i.m. and 300 IU eCG i.m. 1 day before sponge removal. In experiment 2, 23 ewes received two doses of 0.48-mg sodium cloprostenol i.m. 7 days apart. Ovarian follicular dynamic was assessed through transrectal ultrasonography. Blood samples were collected daily to determine progesterone concentrations. In experiment 1, estrus and ovulation rates did not differ (P > 0.05) among protocols and between cyclic and acyclic ewes at the beginning of the experiment. The G9 days treatment showed a lower dispersion of ovulations in relation to onset of estrus when compared to G6 days and G12 days.