Clemastine fumarate - CAS 14976-57-9

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Category
APIs
Product Name
Clemastine fumarate
Catalog Number
14976-57-9
CAS Number
14976-57-9
Molecular Weight
459.97
Molecular Formula
C21H26ClNO·C4H4O4
Quality Standard
USP JP
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MSDS
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Structure
CAS 14976-57-9 Clemastine fumarate
Specification
Purity
>98 %
Appearance
White or off-white crystalline power
Related Products
Reference Reading
1. Antihistamines in the Treatment of Atopic Dermatitis
Sari M. Herman and Ronald B. Vender. Journal of Cutaneous Medicine and Surgery Volume 7 Number 6 December 2003
In much the same way, studies investigating the efficacy of clemastine fumarate, a classic antihistamine, were shown to have contradictory results as no significant antipruritic effect was established in one study conducted by Wahlgreen et al. while another study showed considerable improvement. Cyproheptadine HCl, a serotonin and histamine antagonist with sedative activity, showed improvement in two studies. Baraf compared the antipruritic effect of cyproheptadine HCl to hydroxyzine HCl and demonstrated a reduction in the degree of pruritus but a more significant relief of itching by use of hydroxyzine. Klein and Galant’s comparison of cyproheptadine to hydroxyzine similarly suggested that hydroxyzine was a more effective antihistamine than cyproheptadine in relieving itching associated with AD in children. Lack of a placebo control group made it difficult to determine the actual therapeutic benefit in this study.
2. The Microbiology and Management of Acute and Chronic Rhinosinusitis
James A. Hadley. Current Infectious Disease Reports 2001, 3:209–216
The anticholiergic properties of the first-generation anti-histamines may reduce the rhinorrhea associated with the inflammation, but the drying effects of these products thicken sinus secretions and possibly slow mucociliary clearance. Clemastine fumarate prescribed for volunteers with viral head colds reduced sneezing and rhinorrhea. The newer second-generation antihistamines (acrivastine, cetirizine, fexofenadine, and loratadine) would be favored in patients with an allergic history. The topical antihistamines (azelastine, levocobastine) are extremely potent histamine blockers, but no controlled studies of their use in rhinosinusitis are available at this time.
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