Clebopride - CAS 55905-53-8
Catalog number: 55905-53-8
Category: Main Product
Molecular Formula:
Molecular Weight:
CLEBOPRIDE; 4-amino-5-chloro-2-methoxy-n-(1-(phenylmethyl)-4-piperidinyl)-benzamid; 4-amino-5-chloro-2-methoxy-n-(1-benzyl-4-piperidyl)benzamide; Clebopride (base and/or unspecified salts); 4-Amino-5-chloro-2-(methyloxy)-N-[1-(phenylmethyl)piperidin-4-yl]ben
Boiling Point:
514.7ºC at 760 mmHg
1.27 g/cm3
1.Role of the brain dopaminergic and opioid system in the regulation of "child's" (maternal bonding) behavior of newborn albino rats.
Stovolosov IS1, Dubynin VA, Kamensky AA. Bull Exp Biol Med. 2011 Jan;150(3):281-5.
Administration of D(2) receptor antagonist clebopride in a dose not affecting locomotor activity was followed by a decrease in maternal bonding behavior of 10-day-old and 15-day-old albino rat pups. D(1) receptor antagonist SCH23390 had a stimulatory effect only on the behavior of 10-day-old newborns. Opioid peptide β-casomorphin-7 abolished the effect of clebopride in rat pups of the older age group.
2.[Behavior and functional state of the dopaminergic brain system in pups of depressive WAG/Rij rats].
Malyshev AV, Razumkina EV, Rogozinskaia ÉIa, Sarkisova KIu, Dybynin VA. Zh Vyssh Nerv Deiat Im I P Pavlova. 2014 May-Jun;64(3):334-46.
In the present work, it has been studied for the first time behavior and functional state of the dopaminergic brain system in pups of "depressive" WAG/Rij rats. Offspring of "depressive" WAG/Rij rats at age of 6-16 days compared with offspring of "normal" (non-depressed) outbred rats of the same age exhibited reduced rate of pshychomotor development, lower body weight, attenuation in integration of coordinated reflexes and vestibular function (greater latency of righting reflex, abnormal negative geotaxis), hyper-reactivity to tactile stimulation, reduced motivation to contact with mother (reduced infant-mother attachment). Differences in a nest seeking response induced by olfactory stimuli (olfactory discrimination test) and in locomotor activity (tests "gait reflex" and "small open field") have not been revealed. Acute injection of the antagonist of D2-like dopamine receptors clebopride 20 min before testing aggravated mother-oriented behavior in 15-days-old pups of both "depressive" and "non-depressive" rats.
3.Development and validation of a LC-MS/MS method for the determination of clebopride and its application to a pharmacokinetics study in healthy Chinese volunteers.
Tan Z1, Ouyang D, Chen Y, Zhou G, Cao S, Wang Y, Peng X, Zhou H. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Aug 1;878(23):2072-6. doi: 10.1016/j.jchromb.2010.06.006. Epub 2010 Jun 9.
A sensitive and specific liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS/MS) method has been developed and validated for the identification and quantification of clebopride in human plasma using itopride as an internal standard. The method involves a simple liquid-liquid extraction. The analytes were separated by isocratic gradient elution on a CAPCELL MG-III C(18) (5 microm, 150 mm x 2.1 mm i.d.) column and analyzed in multiple reaction monitoring (MRM) mode with positive electrospray ionization (ESI) interface using the respective [M+H](+) ions, m/z 373.9-->m/z184.0 for clebopride, m/z 359.9-->m/z71.5 for itopride. The method was validated over the concentration range of 69.530-4450.0 pg/ml for clebopride. Within- and between-batch precision (RSD%) was all within 6.83% and accuracy ranged from -8.16 to 1.88%. The LLOQ was 69.530 pg/ml. The extraction recovery was on an average 77% for clebopride. The validated method was used to study the pharmacokinetics profile of clebopride in human plasma after oral administration of clebopride.
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