cis-ROSE OXIDE - CAS 3033-23-6
Category:
Flavor & Fragrance
Product Name:
cis-ROSE OXIDE
Synonyms:
(* Alt. CAS #) CAS: 16409-43-1; Rose Oxide, 2H-Pyran, tetrahydro-4-methyl-2- (2-methyl-1-propenyl)-, (2S-cis)-, cis-ROSE OXIDE, FEMA CAS: 16409-43-1
CAS Number:
3033-23-6
Molecular Weight:
154.24
Molecular Formula:
C10H18O
COA:
Inquire
MSDS:
Inquire
Olfactive Family:
Floral | Green
FEMA:
3236
Odor description:
A clean floral, green rosy, fresh, geranium odor.
Chemical Structure
CAS 3033-23-6 cis-ROSE OXIDE

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Reference Reading


1.Metabolism of (-)-cis- and (-)-trans-rose oxide by cytochrome P450 enzymes in human liver microsomes.
Nakahashi H1, Yamamura Y1, Usami A1, Rangsunvigit P2, Malakul P2, Miyazawa M1. Biopharm Drug Dispos. 2015 Dec;36(9):565-74. doi: 10.1002/bdd.1965. Epub 2015 Oct 31.
The in vitro metabolism of (-)-cis- and (-)-trans-rose oxide was investigated using human liver microsomes and recombinant cytochrome P450 (P450 or CYP) enzymes for the first time. Both isomers of rose oxide were incubated with human liver microsomes, and the formation of the respective 9-oxidized metabolite were determined using gas chromatography-mass spectrometry (GC-MS). Of 11 different recombinant human P450 enzymes used, CYP2B6 and CYP2C19 were the primary enzymes catalysing the metabolism of (-)-cis- and (-)-trans-rose oxide. CYP1A2 also efficiently oxidized (-)-cis-rose oxide at the 9-position but not (-)-trans-rose oxide. α-Naphthoflavone (a selective CYP1A2 inhibitor), thioTEPA (a CYP2B6 inhibitor) and anti-CYP2B6 antibody inhibited (-)-cis-rose oxide 9-hydroxylation catalysed by human liver microsomes. On the other hand, the metabolism of (-)-trans-rose oxide was suppressed by thioTEPA and anti-CYP2B6 at a significant level in human liver microsomes.