1. Characterisation of the lowest singlet and triplet excited states of S-ﬂurbiprofen
M. Consuelo Jim´ enez, Miguel A. Miranda,* Rosa Tormos and Ignacio Vaya. Photochem. Photobiol. Sci. , 2004, 3 , 1038–1041
In this context, although the photophysical properties of a number of antiinﬂammatory 2-arylpropionic acids (i.e. naproxen, benoxaprofen, carprofen, ketoprofen, tiaprofenic acid and suprofen) have been previoulsy described, the ﬁrst singlet excited state of FBP has not yet been fully characterised. Besides, there is no report on the lowest lying FBP triplet, in spite of its potential interest as a reporter of the physicochemical properties of its environment when complexed with biomolecules. A detailed investigation on the photophysical properties of FBP would also be helpful to understand its photoreactivity, which involves initial cleavage of the C–C bond ato the carbonyl group, ultimately leading to decarboxylation products.
2. Generation of reactive aryl radical intermediates in the reductive photodehalogenation of Itraconazole
Giacomo Nardi, M. Luisa Marin, Pierre A. de Souza, Virginie Lhiaubet-Vallet* and Miguel A. Miranda*. RSC Adv.,2014, 4,2687–2693
The whole scenario could change in the presence of good H donors, as illustrated in the literature for the non steroidal antiinflammatory drugs carprofen and diclofenac. In these cases, photodechlorination was proposed to be the key process from a toxicological point of view. Thus, C–Cl cleavage would be the source of highly reactive radicals, which for carprofen and diclofenac (through its cyclized photoproduct) were demonstrated to be in the origin of photohemolysis and photodynamic lipid peroxidation. In fact, aryl radicals are able to abstract hydrogen from lipids, mediating their peroxidation by a type I mechanism.
3. Pharmacologically active compounds in the environment and their chirality
Barbara Kasprzyk-Hordern*. Chem. Soc. Rev., 2010, 39, 4466–4503
NSAIDs. NSAIDs are the most widely studied chiral drugs in humans in terms of their stereoselective action. Chiral NSAIDs are used as anti-inﬂammatory, antipyretic and analgesic agents. Among 2-arylpropionic acids (2-APA) there are: ibuprofen, ketoprofen, fenoprofen, ﬂurbiprofen, tiaprofenic acid, carprofen, pirprofen, benoxaprofen and naproxen.