carbamazepine - CAS 298-46-4

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Category
APIs
Product Name
carbamazepine
Catalog Number
298-46-4
CAS Number
298-46-4
Molecular Weight
239.27
Molecular Formula
C15H12N2O
COA
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MSDS
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Structure
CAS 298-46-4 carbamazepine
Specification
Purity
93~103%
Appearance
white crystalline powder
Related Products
Reference Reading
1. Adsorption of the antiepileptic carbamazepine onto agricultural soils
Vania Calisto and Valdemar I. Esteves*. J. Environ. Monit., 2012, 14, 1597–1603
Carbamazepine is an antiepileptic pharmaceutical which is consumed worldwide and it is one of themost frequently detected pharmaceuticals in the environment. It was found to be highly resistant to bio- and photodegradation in aquatic environments and it has been pointed out as a potential wastewater indicator, being important to consolidate knowledge about its behavior and fate. Some physical and chemical properties of carbamazepine, relevant to predict its sorption behavior, are detailed in Table 1.
2. Influence of organic surface coatings on the sorption of anticonvulsants on mineral surfaces
Shen Qu and David M. Cwiertny*. Environ. Sci.: Processes Impacts, 2013, , 2038–2049
The behavior of carbamazepine in surfactant-containing ferrihydrite suspensions also provides insight as to how coatings of SDBS and CPC influence PPCP sorption. Because carbamazepine is neutrally charged over all pH values, any enhanced sorption must primarily result from partitioning into hydrophobic surfactant layers. Indeed, in SDBS-containing ferrihydrite suspensions, carbamazepine uptake increased with total SDBS concentration, consistent with our phenytoin results and our proposal that SDBS surface layers increase sorption primarily via hydrophobic interactions.
3. Screening strategies based on solubility and solution composition generate pharmaceutically acceptable cocrystals of carbamazepine
Scott L. Childs,* NaırRodrıguez-Hornedo,* L. Sreenivas Reddy. CrystEngComm, 2008, 10, 856–864
The study of carbamazepine solid forms continues to be a forum for advancing fundamental knowledge about polymorphism, hydrate formation, crystal engineering of pharmaceuticals, and structure–property relationships of pharmaceutical relevance. The molecular structure of carbamazepine (CBZ) is shown in Fig. 1. The bioavailability of carbamazepine, an anti-epileptic drug with low water solubility, is dissolution-rate limited and is thus affected by the crystalline form used in the formulation. The study of cocrystals of carbamazepine has been a particularly active area of research, including a recent report that a cocrystal of carbamazepine and saccharin was shown to be bioequivalent to carbamazepine form III in dogs.
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