|Description||Camptothecin (CPT) is a potent DNA enzyme topoisomerase I (topo I) inhibitor with an IC50 and IC70 of 50 nM and 0.225 μM for breast cancer cell line MDA-MB-231.|
Dantrolene sodium is a postsynaptic muscle relaxant that lessens excitation-contraction coupling in muscle cells. It achieves this by inhibiting Ca2+ ions relea...
Potent antagonist for α7-containing neuronal nicotinic receptors (Ki = 1.4 nM). Interacts with α4β2 and α6β2 receptors at concentrations > 40 nM. Attenuates MET...
A methyl easter of Okadaic acid. Okadaic acid is a marine sponge toxin which potently inhibits certain serine/threonine protein phosphatases.
alpha and beta Adrenoreceptors subtypes agonist; MAO inhibitor. Alkaloid derivative of (+)-Pseudoephedrine from plants of the Ephedra genus, Ephedraceae.
Diplacine is a nicotinic cholinoreceptor antagonist at the neuromuscular junction.
Hydrastine is a natural alkaloid which is present in Hydrastis canadensis and other plants of the ranunculaceae family.
Synthetic, nicotinic AChR. Rigid bicyclic analog of TMA and TEA.
AChR agonist. Rigid bicyclic analog of ACh and ARECOLINE. Good penetration of biological membranes. Quinuclidine derivative, , synthetic.
Delsoline is a hypotensive alkaloid isolated from Aconitum.
SNX-482 has been isolated from the venom of the Spider Hysterocrates gigas (African tarantula). SNX-482 modulates the R-type current associated with the class α...
Synthetic organophosphorous compound, a non-competitive GABA antagonist; potent convulsant: causes epileptoform seizures.
Synthetic, GABAA-gated Cl- channels blocker; non-competitive GABAA antagonist.
Atropine is a medication used to treat certain types of nerve agent and pesticide poisonings, some types of slow heart rate, and to decrease saliva production d...
Potent inhibitor of Ca2+ release from sarcoplasmic reticulum
anti-hypoxic; acts on the mitochondrial respiratory chain; prevents atherosclerosis; angioprotector. Sum of polymerized Proantocyanides , from the plants of Fab...
Alkaloid, Tetrahydroisoquinoline, Active dopamine metabolite, Cholinesterase inhibitor
α-Dendrotoxin inhibits 4-AP sensitive, inactivating voltage-gated<br/>K+ channels (KV1.1, KV1.2 and KV1.6).
Iron carrier Synthetic
Idarubicin is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL.
Apamin is an 18 amino acid peptide toxin found in bee venom. Apamin is used to elucidate the roles of these channels in cells and tissues expressing SK channels...