1.Single Nucleotide Polymorphisms in the BDNF, VDR, and DNASE 1 Genes in Dry Eye Disease Patients: A Case-Control Study.
Hallak JA1, Tibrewal S2, Mohindra N2, Gao X3, Jain S2. Invest Ophthalmol Vis Sci. 2015 Sep;56(10):5990-6. doi: 10.1167/iovs.15-17036.
PURPOSE: To identify single nucleotide polymorphisms (SNPs) in the brain-derived neurotrophic factor (BDNF), vitamin D receptor (VDR), and DNASE1 genes that may be associated with dry eye disease (DED), and determine whether this association varies by the presence of depression.
2.[BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF): NEUROBIOLOGY AND MARKER VALUE IN NEUROPSYCHIATRY].
Levada OA, Cherednichenko NV. Lik Sprava. 2015 Apr-Jun;(3-4):15-25.
In this review current publications about neurobiology and marker value of brain derived neurotrophic factor (BDNF) in neuropsychiatry are analyzed. It is shown that BDNF is an important member of the family of neurotrophins which widely represented in various structures of the CNS. In prenatal period BDNF is involved in all stages of neuronal networks formation, and in the postnatal period its main role is maintaining the normal brain architectonics, involvement in the processes of neurogenesis and realization of neuroprotective functions. BDNF plays an important role in learning and memory organization, food and motor behavior. BDNF brain expression decreases with age, as well as in degenerative and vascular dementias, affective, anxiety, and behavioral disorders. The reducing of BDNF serum, level reflects the decreasing of its cerebral expression and could be used as a neurobiological marker of these pathological processes but the rising of its concentration could indicate the therapy effectiveness.
3.Association of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism with early-onset bipolar disorder.
Nassan M1, Croarkin PE1, Luby JL2, Veldic M1, Joshi PT3, McElroy SL4, Post RM5, Walkup JT6, Cercy K7, Geske JR7, Wagner KD8, Cuellar-Barboza AB9, Casuto L4, Lavebratt C10,11, Schalling M10,11, Jensen PS12, Biernacka JM1,7, Frye MA1. Bipolar Disord. 2015 Sep;17(6):645-52. doi: 10.1111/bdi.12323.
OBJECTIVES: Brain-derived neurotrophic factor (BDNF) Val66Met (rs6265) functional polymorphism has been implicated in early-onset bipolar disorder. However, results of studies are inconsistent. We aimed to further explore this association.