Industry News

The Magical Biotin

The Magical Biotin

What is Biotin? Biotin, with a molecular weight of 244.31, consists of two cyclic structures. The first ring is the imidazolone ring, the primary site for binding with avidin; the […]

Comparison and Analysis of SMDC, ADC, and DAC

Comparison and Analysis of SMDC, ADC, and DAC

In order to more effectively deliver chemotherapy drugs, Small Molecule Drug Conjugates (SMDC), Antibody Drug Conjugates (ADC), and Degradation Antibody Conjugates (DAC) have been successively explored and developed, enhancing the […]

Clinical Prospects of Aptamer Applications

Clinical Prospects of Aptamer Applications

Aptamers are short RNA/DNA oligonucleotide molecules that bind specifically to complementary target molecules. As potential recognition elements, aptamers show promising applications in both diagnosis and treatment. They offer diverse therapeutic and diagnostic […]

CD137/4-1BB combination therapy

Two Paths of Second-Generation 4-1BB Agonists

CD137/4-1BB combination therapy

Types of Delivery Systems of mRNA Cancer Vaccines

Types of Delivery Systems of mRNA Cancer Vaccines

Brief Description of mRNA Delivery Systems As a therapeutic use, mRNA cancer vaccines have the advantages of high safety, strong immune activation ability, and short production cycle. Moreover, mRNA cancer […]

Design Ideas for FDA-Approved Small Molecule Drugs in the third quarter of 2023

Design Ideas for FDA-Approved Small Molecule Drugs in the third quarter of 2023

FDA approved the marketing of 14 drugs in the third quarter of 2023, including 6 small molecule drugs. This article mainly focuses on the drug design ideas of small molecule drugs, hoping […]

Research and clinical progress in RNA therapy

RNA-based therapeutics The Human Genome Project (HGP) has revealed a wealth of information about the human genome and has greatly enhanced its role in the development of biomedical research. Thanks […]

tRNA

tRNA Therapy: A New Option in the Age of mRNAs

In recent years, rapid advancements in gene therapy have brought about a significant transformation in modern medicine. The application of advanced molecular biology techniques and enhanced delivery systems has ushered […]

cmc

CMC Regulatory Considerations for ADCs

Antibody drug conjugates (ADCs) are a new class of biopharmaceuticals that use monoclonal antibodies to target tumor cells to deliver potent cytotoxic drugs. So far, a total of 15 ADC drugs […]

mRNA technologies

Effect of Codons and Secondary Structure on mRNA Protein Expression Levels

mRNA serves as templates for creating proteins, and the quantity of protein generated from each mRNA molecule is contingent on how the translation apparatus commences or elongates the coding sequence (CDS). Additionally, […]