Not Intended for Therapeutic Use. For research use only.

Betamethasone - CAS 378-44-9

Quick Inquiry

Name:
* Email:
* Service & Products of Interest:
* Quantity:
* Verification code:
Please input "bocsci" as verification code.
Category
Inhibitor
Product Name
Betamethasone
Catalog Number
378-44-9
Synonyms
9α-Fluoro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione; 9α-Fluoro-16β-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione; 9α-Fluoro-16β-methylprednisolone
CAS Number
378-44-9
Description
Betamethasone is a potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties. Unlike other drugs with these effects, betamethasone does not cause water retention. It is applied as a topical cream, ointment, foam, lotion or gel to treat itching. Betamethasone sodium phosphate is sometimes prescribed as an intramuscular injection (I.M) for itching from various ailments, including allergic reactions to poison ivy and similar plants.
Molecular Weight
392.46
Molecular Formula
C22H29FO5
Quantity
Grams-Kilos
Quality Standard
EP
COA
Certificate of Analysis-Betamethasone 378-44-9 B15L0908  
MSDS
Inquire
Targets
Glucocorticoid Receptor
Structure
CAS 378-44-9 Betamethasone
Specification
Purity
99%
Appearance
White powder
Application
API
Related Glucocorticoid Receptor Products
  • CAS 5534-09-8 Beclomethasone dipropionate

    Beclomethasone dipropionate
    (CAS: 5534-09-8)

    Beclomethasone dipropionate is a potent glucocorticoid steroid used for the treatment of rhinitis and sinusitis.

  • CAS 50-02-2 Dexamethasone

    Dexamethasone
    (CAS: 50-02-2)

    Glucocorticoid; anti-inflammatory. Reduces levels of activated NF-κB in immature dendritic cells (DCs) and inhibits differentiation into mature DCs. Induces dif...

  • Betamethasone hydrochloride
    (CAS: 956901-32-9)

    Betamethasone hydrochloride is the hydrochloride of betamethasone, which is a synthetic corticosteroid and agonist of glucocorticoid receptor. It does not cause...

  • CAS 67-73-2 Fluocinolone Acetonide

    Fluocinolone Acetonide
    (CAS: 67-73-2)

    Fluocinolone acetonide is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. It was also found to strongly potentia...

  • CAS 152-58-9 Cortodoxone

    Cortodoxone
    (CAS: 152-58-9)

    Cortodoxone, a glucocorticoid receptor antagonist, is an intermediate which can be oxygenated to cortisol.

  • CAS 397864-44-7 Fluticasone furoate

    Fluticasone furoate
    (CAS: 397864-44-7)

    Fluticasone furoate is a synthetic corticosteroid derived from fluticasone as a selective high affinity glucocorticoid agonist, MRP4 inhibitor;

  • CAS 51333-22-3 Budesonide

    Budesonide
    (CAS: 51333-22-3)

    Budesonide is a glucocorticoid steroid that activates the glucorcorticoid receptor with an EC50 value of 12.4 nM. Like other glucocorticoids, budesonide reduces...

  • CAS 1177-87-3 Dexamethasone Acetate

    Dexamethasone Acetate
    (CAS: 1177-87-3)

    The acetate-protect form of Dexamethasone which is a glucocorticoid and could be used as a anti-inflammatory agent.

  • CAS 1247-42-3 Meprednisone

    Meprednisone
    (CAS: 1247-42-3)

    Meprednisone is a glucocorticoid and a methylated derivative of prednisone.

  • CAS 3385-03-3 Flunisolide Hemihydrate

    Flunisolide Hemihydrate
    (CAS: 3385-03-3)

    Flunisolide, a kind of corticosteroid compound, often being used against allergic rhinitis by activating glucocorticoid receptors. It was also found that it mig...

  • CAS 378-44-9 Betamethasone

    Betamethasone
    (CAS: 378-44-9)

    Betamethasone is a potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties. Unlike other drugs with these effects, betamethasone d...

  • CAS 50-24-8 Prednisolone

    Prednisolone
    (CAS: 50-24-8)

    Prednisolone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.

  • CAS 80474-14-2 Fluticasone propionate

    Fluticasone propionate
    (CAS: 80474-14-2)

    Fluticasone propionate (Flonase, Veramyst) is a synthetic corticosteroid which is derived from fluticasone used to treat asthma and allergic rhinitis (hay fever...

  • CAS 50-23-7 Hydrocortisone

    Hydrocortisone
    (CAS: 50-23-7)

    Hydrocortisone is a steroid hormone or glucocorticoid produced by the adrenal gland.

  • CAS 1245526-82-2 Glucocorticoid receptor agonist

    Glucocorticoid receptor agonist
    (CAS: 1245526-82-2)

    Glucocorticoid receptor agonist is an effective Glucocorticoid receptor agonist and probably has steroid-like anti-inflammatory properties.

  • CAS 51022-69-6 Amcinonide

    Amcinonide
    (CAS: 51022-69-6)

    Amcinonide is a corticosteroid (IC50=3.38 nM) used as anti-inflammatory and antipruritic agents.

  • CAS 84371-65-3 Mifepristone

    Mifepristone
    (CAS: 84371-65-3)

    Mifepristone is a progesterone receptor antagonist(IC50= 0.2 nM) and a glucocorticoid receptor antagonist(IC50= 2.6 nM). It is used as an abortifacient in the f...

  • CAS 82034-46-6 Loteprednol etabonate

    Loteprednol etabonate
    (CAS: 82034-46-6)

    Loteprednol etabonate is an anti-inflammatory corticosteroid used in ophthalmology.

  • CAS 22427-39-0 Ginsenoside Rg1

    Ginsenoside Rg1
    (CAS: 22427-39-0)

    Ginsenoside Rg1 is extrected from the roots of Panax ginseng C. A. Mey. It has estrogen-like activity and should be classified as a novel class of potent phytoe...

  • CAS 50-04-4 Cortisone acetate

    Cortisone acetate
    (CAS: 50-04-4)

    Cortisone acetate (Cortone) is an acetate salt form of cortisone that is a steroid hormone and a glucocorticoid.

Reference Reading
1. Evaluation of electrospun fibers as solid phase extraction sorbents for sample preparation in HPLC-MS/MS confirmatory doping control analysis of dexamethasone and betamethasone
Tania Possi-Pezzali, Samuel Chigome, Alejandra Rodr´ ıguez-Haralambides*, Nelson Torto. Anal. Methods, 2013, 5, 4230–4237
Polystyrene fibers were fabricated by electrospinning and evaluated their capacity to interact with twomodel drugs for sample preparation. The packing in microcolumn devices showed high recoveries for dexamethasone and betamethasone in water and urine samples, and breakthrough volumes measured for both analytes indicated that the system could be applicable not only for a clean-up but also as a pre-concentration step. This sample preparation approach was successfully applied to urine samples to detect the presence of dexamethasone and betamethasone by HPLC-MS/MS for qualitative confirmatory analyses. The method requires only 200 mL of methanol per sample, and the extraction is performed in less than 15 min.
2. The conversion of allenes to strained three-membered heterocycles
C. S. Adams, C. D. Weatherly, E. G. Burke and J. M. Schomaker*. Chem. Soc. Rev., 2014, 43, 3136—3163
In 1996, chemists at Schering-Plough reported an alternative approach to the corticoid betamethasone that proceeded through an SDE intermediate. Treatment of the steroidal allene with in situ-generated DMDO provided the requisite SDE in 2 : 1 dr; however, ring-opening with Bu4NOAc provided a single ketone product, indicating that the source of diastereoselectivity was at C20. The disubstituted ketone was obtained in 85% over two steps, and was readily carried on to a known betamethasone precursor.
3. Quantitative determination of betamethasone sodium phosphate and betamethasone dipropionate in human plasma by UPLC-MS/MS and a bioequivalence study
Man-Yun Chen, Yong-Jun Tang, Zhi-Rong Tan,* Wei-Hua Huang*. Anal. Methods,2016, 8, 3550–3563
BSP and BDP could be hydrolyzed by phosphatase as fast-release phosphate prodrugs and esterase enzymes as sustained-release dipropionate prodrugs into active pharmaceutical ingredients betamethasone (BOH), betamethasone 17-monodipropionate (B17P) and betamethasone 21-monodipropionate (B21P), respectively. Because the activating enzymes such as phosphate and esterase were highly efficient and ubiquitous in human blood, BSP that was highly ionized and hydrophilic could be rapidly absorbed into blood from the administration place and then be metabolized quickly into active betamethasone (BOH) without a rate-limiting step.
2005 - BOC Sciences | All rights reserved
BOCSciences
X CLOSE
BOCSciences
X CLOSE
BOCSciences
X CLOSE
BOCSciences
X CLOSE
BOCSciences
X CLOSE
BOCSciences
X CLOSE
BOCSciences
X CLOSE
BOCSciences
X CLOSE
BOCSciences
X CLOSE
BOCSciences
X CLOSE
BOCSciences
X CLOSE
BOCSciences
X CLOSE
BOCSciences
X CLOSE
BOCSciences
X CLOSE
BOCSciences
X CLOSE
DOWNLOAD