(beta)-Estradiol 17-acetate - CAS 1743-60-8
Not Intended for Therapeutic Use. For research use only.
Category:
Inhibitor
Product Name:
(beta)-Estradiol 17-acetate
Catalog Number:
1743-60-8
Synonyms:
1,3,5(10)-Estratriene-3,17β-diol 17-acetate
CAS Number:
1743-60-8
Description:
β-Estradiol 17-acetate is a metabolite of estradiol.
Molecular Weight:
314.42
Molecular Formula:
C20H26O3
COA:
Inquire
MSDS:
Inquire
Targets:
Others
Chemical Structure
CAS 1743-60-8 (beta)-Estradiol 17-acetate

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Reference Reading


1.LCAT facilitates transacylation of 17 beta-estradiol in the presence of HDL3 subfraction.
Höckerstedt A1, Tikkanen MJ, Jauhiainen M. J Lipid Res. 2002 Mar;43(3):392-7.
It has been shown that estrogens need to be metabolized to their hydrophobic estrogen ester derivatives to act as antioxidants in lipoproteins. Data suggest that 17beta-estradiol (E(2)) becomes esterified in LCAT-induced reactions and the esters are transported from HDL particles to LDL and VLDL particles by a CETP-dependent mechanism. In the present study we have further investigated the regulation of E(2) esterification by LCAT and focused on the importance of HDL structure and composition in the esterification process. Isolated LDL, HDL(2), HDL(3), and reconstituted discoidal HDL (rHDL) were incubated with labeled E(2), with and without purified LCAT, at 37 degrees C for 24 h. After purification of the lipoprotein fractions, there was a significant peak of radioactivity representing esterified estradiol attached to HDL(3) and rHDL, but HDL(2) and LDL contained only trace amounts of labeled estradiol ester. TLC analysis confirmed that the radioactivity migrated in a position corresponding to that of 17beta-E(2) 17-monoester standard.
2.The influence of 17-beta-estradiol 17-beta-acetate on adenylyl cyclase activity and aminoacyl-tRNA synthetase phosphatase activity in ovariectomized NMRI mice.
Berg BH1. Biochem Int. 1991 Jun;24(3):527-33.
Adenylyl cyclase activity in the uterus of ovariectomized NMRI mice showed an increase of 87% four minutes after intraperitoneal administration of 17-beta-estradiol 17-beta-acetate in water solution, while in the liver of the same animals activity had decreased by 57%. At the same time, the activity of the 51 kDa form of the aminoacyl-tRNA synthetase phosphatase in the uterus showed an increase of 400%, while in the liver a decrease of 60% was observed. Sixty minutes after hormone injection the adenylyl cyclase activities showed no difference from controls.
3.Reversal of the effect of 17-beta-estradiol 17-beta-acetate on aminoacyl-tRNA synthetase phosphatase and aminoacyl-tRNA synthetase activities in the uterus and liver of ovariectomized Bom:NMRI mice by 2-deoxyadenosine 3-phosphate.
Berg BH1. Biochem Mol Biol Int. 1993 Apr;29(5):959-64.
When an adenylyl cyclase inhibitor, 2-deoxyadenosine 3'-phosphate, was administered together with 17-beta-estradiol 17-beta-acetate on ovariectomized Bom:NMRI mice, the short term effects of the hormone on the uterus aminoacyl-tRNA synthetase phosphatase and aminoacyl-tRNA synthetase activities were reversed, whereas the effect on the liver enzymes was about the same for 17-beta-estradiol 17-beta-acetate and for 2-deoxyadenosine 3-phosphate.
4.Synthesis and properties of benzo [d,e]estra-1,3,5(10)-triene-3, 17 beta-diol 17-acetate.
Castelli PP, Vitali R, Briziarelli G, Gardi R. Experientia. 1981 Jan 15;37(1):10-1.
A new pentacyclic analogue of estradiol, benzo[d,e]estradiol 17-acetate, has been prepared and investigated for its hormonal and antitumor activity. Unlike related testosterone derivatives, the new compound did not display any interesting property.