1.Oral Nanoparticulate Atorvastatin Calcium is More Efficient and Safe in Comparison to Lipicure in Treating Hyperlipidemia
A. K. Meena, D. Venkat Ratnam, G. Chandraiah. Lipids (2008) 43:231–241
We hypothesize that oral nanoparticulate formulations by virtue of their unique uptake mechanism and sustained release of the loaded drug would improve the efficacy of atorvastatin and at the same time reduce the associated side effects. Therefore, the present work deals with the development of atorvastatin calcium nanoparticles using a biodegradable polymer, poly(lactide-co-glycolate) (PLGA) and their evaluation in hyperlipidemic rats for efficiency as well as safety.
2.Rapid Insight into Heating-Induced Phase Transformations in the Solid State of the Calcium Salt of Atorvastatin Using Multivariate Data Analysis
Niels Peter Aae Christensen & Bernard Van Eerdenbrugh. Pharm Res (2013) 30:826–835
The aim of the present study was to investigate heatinginduced solid-state changes encountered during dehydration and melting of the trihydrate of the calcium salt of atorvastatin (THCaA, Fig. 2) with a focus on increasing the understanding of the physical instability of hydrate forming drugs at elevated temperatures in typical pharmaceutical manufacturing environments. The THCaA system is a prime candidate for the MCR approach on VT-XRPD data, because crystal structures have not so far been reported for any of the hydrate or anhydrous phases. Synchrotron XRPD data have previously been reported for THCaA, from which a unit cell has been deduced by Pawley refinement. However, full structural information has not been established. Here, we use MCR to decode the information in a variable-temperature XRPD data matrix and show that this approach can provide a rapid interpretation of complex dehydration behavior, even in the absence of detailed structural knowledge.
3.Synthesis, spectral, thermal, and antimicrobial studies of transition metal complexes of atorvastatin calcium as a lipid-lowering agent
Moamen S. Refat • Foziah A. Al-Saif. J Therm Anal Calorim (2015) 120:863–878
The thermal behavior of atorvastatin free ligand and their all complexes has been studied as a function of temperature. The decomposition nature of suggested structures with temperature and the residual products are given in Table 8. Thermal steps of atorvastatin complexes were discussed upon TG and DTG diagrams corresponding to these complexes are shown in Fig. 4.
4.Effects of atorvastatin on calciumregulating proteins: a possible mechanism to repair cardiac dysfunction in spontaneously hypertensive rats
Lei Yao, Guo-Ping Chen, Xian Lu. Basic Res Cardiol 104:258–268 (2009)
The investigation conformed to the Guide for the Care and Use of Laboratory Animals published by the US National Institutes of Health (NIH Publication No.85-23, revised 1996) and the guidelines of the Animal Care and Use Committee of Zhejiang University. Experiments were carried out using 8-week-old male SHR and Wistar Kyoto rats (WKY) (clean grade, provided by Shanghai Laboratory Animal Center, Chinese Academy of Sciences). Rats of each strain were divided into four groups, and were given (by gavage for 10 weeks) either 1 ml distilled water, atorvastatin (50 mg/kg/day), amlodipine (2 mg/kg/day), or both, mixed with 1 ml distilled water. In total, we used 8 groups of rats: WKY-placebo (n = 8), WKY-atorvastatin (n = 6), WKY-amlodipine (n = 4), WKY-combined (n = 4), SHR-placebo (n = 8), SHR-atorvastatin (n = 8), SHR-amlodipine (n = 5), and SHR-combined (n = 5). Amlodipine (2 mg/kg/day) was used as a drug control for blood pressure. All rats were housed under similar conditions on a 12-h light/dark cycle with the temperature maintained at 21 ± 1℃, humidity at 55% ± 5%, and free access to the same diet and water.