Monomethylauristatin F Hcl(MMAF Hcl) is an antitubulin agent that inhibit cell division by blocking the polymerization of tubulin; lower cytotoxic activity than...
An antiarrhythmic of 1-st and 1Y classes and a blocker of TTX sensitive Na+ channels, Ca++ antagonist diterpene alkaloid from Delphinium staphisagria.
Irofulven is a semisynthetic sesquiterpene derivative of illudin S, a natural toxin isolated from the fungus Omphalotus illudens. Irofulven alkylates DNA and pr...
Estrogenic activity; half agonist of estradiol receptors. Complex esters of phenolcarbon acids, , from plants of the Ferula genus, Umbelliferae.
Anti-inflammatory, antioxidant and free radical scavenger. Inhibits LPS-induced TNF-α, IL-6 and inducible nitric oxide production and blocks NF-κB and AP-1 acti...
Ruthenium red is a polycationic dye that inhibits sarcoplasmic reticulum Ca2+ release, blocks Ca2+ uptake and release from mitochondria, and prevents Ca2+ relea...
A latrotoxin is a high-molecular mass neurotoxin found in the venom of spiders of the genus Latrodectus (widow spiders). Latrotoxins are the main active compone...
Mebicyphat is shown to be a non-competitive GABA antagonist. Blocks GABA gated Cl- channels, and is shown to inhibit dihydropicrotoxin
Donaxine is a naturally occurring indole alkaloid present in several plant species; Analeptic of CNS, tocolytic indole alkaloid Derived from the basic alkaloid ...
Synthetic, an inhibitor of monoamine oxydase.
Duocarmycin is a cytotoxic agent, used as the cytotoxic component in antibody-drug conjugates.
DM 4 is an intermediate used to prepare semisynthetic maytansine analogs which can be conjugated with antibodies for the targeted treatment of cancer.
Daunorubicin Hcl inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 μM.
Synthetic, a selective irreversible inhibitor of carboxylesterases
Margatoxin (MgTx) is a component of the venom of Scorpio Centruroides margaritatus. Margatoxin preferentially inhibits voltage-dependent potassium channels Kv1....
Terpenoids found in the umbelliferae family act as agonists/antagonists for ER(alpha) and Erbeta.
Sesquiterpene lactone , from plants of the Compositae family, an antiatherosclerotic, angioprotective, hypolipidemic and anti-inflammatory.
Nitrodienamine, an inhibitor of Ca2+/Mg2+ ATPase.
A methyl easter of Okadaic acid. Okadaic acid is a marine sponge toxin which potently inhibits certain serine/threonine protein phosphatases.
TTX is a potent marine-derived neurotoxin that reversibly inhibits the inward sodium current through voltage-activated sodium (NaV) channels, blocking nerve and...