α-Neurotoxins from snake venoms that tightly bind nAChRs contain 60-75 amino acid (aa) residues and are linked by 4-5 disulfide bridges. an antagonist of the ni...
omega conotoxin MVIIA
ω conotoxin MVIIA (omega conotoxin MVIIA) has been isolated from the venom of the cone Conus magus. Omega-conotoxins act at presynaptic membranes, they bind and...
Triptolide is a diterpene triepoxide, immunosuppresive agent extracted from the Chinese herb Tripterygium wilfordii.
Alkaloid from reticuline and is a precursor of berberine.It has also been found to be a GABAA receptor agonist.
Rebaudioside A is a glycoside from the stevia plant. Rebaudioside A is used as a sweetener with sweetness about 300 times that of sugar with negligible effect o...
Derivative of Desoxypeganine from plants of the Zygophyllaceae family, a psychotomimetic agent on dogs and cats; acetylcholinesterase inhibitor.
A cytolytic toxin that causes depolarization of skeletal muscle fibers in vitro. Stimulates Ca2+ transport and ATP hydrolysis by the sarcolemmal Ca2+/Mg2+-ATPas...
A SR-4 agonist with moderate activity as a SR-3 antagonist
Melamine is a widely used, broad-spectrum benzimidazole fungicide and a metabolite of benomyl. It is also employed as a casting worm control agent in amenity tu...
Dantrolene sodium is a postsynaptic muscle relaxant that lessens excitation-contraction coupling in muscle cells. It achieves this by inhibiting Ca2+ ions relea...
Lignan , from plants of the Rutaceae family, a substance presenting an estrogenic activity and sedative effects. .
Evoxine (haploperine) is a furoquinoline alkaloid with hypnotic and sedative effects. It is found naturally in a variety of Australian and African plants includ...
Diazoxide is a potassium channel activator that causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. The cellular rel...
Morphiceptin is a four amino acid peptide derived from the ß-casomorphin, a protein fragment itself derived from the digestion of milk protein casein. It is one...
Sevedindione presents an antiarrhythmic activity on arrhythmias caused by Aconitine.
Aporphin alkaloid derivative of Isocorydine from plants of the Corydalis genus, Fumariaceae, a long-lasting ganglioblocker, with a sympathetic/parasympathetic a...
Potent blocker of voltage-sensitive K+ channels (IC50 values are 0.1, 1.1 and 25 nM for KV1.3, KV1.1 and KV1.2 channels) respectively). Also inhibits Ca2+-activ...
Synthetic, nicotinic AChR. Rigid bicyclic analog of TMA and TEA.
Tschimgine a substance presenting an estrogenic activity..
Brevetoxin PbTx 1
An activator of voltage-sensitive Na+ channels, a suite of cyclic polyether compounds produced naturally by a species of dinoflagellate known as Karenia brevis....